Search Results - "Beyer, L. A."

BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice by Fukui, H., Wong, H. T., Beyer, L. A., Case, B. G., Swiderski, D. L., Di Polo, A., Ryan, A. F., Raphael, Y.

“…Current therapy for patients with hereditary absence of cochlear hair cells, who have severe or profound deafness, is restricted to cochlear implantation, a…”
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Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome by Layman, W.S., McEwen, D.P., Beyer, L.A., Lalani, S.R., Fernbach, S.D., Oh, E., Swaroop, A., Hegg, C.C., Raphael, Y., Martens, J.R., Martin, D.M.

“…Mutations in CHD7, a chromodomain gene, are present in a majority of individuals with CHARGE syndrome, a multiple anomaly disorder characterized by ocular…”
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RNA Polymerase II Elongation Factors Spt4p and Spt5p Play Roles in Transcription Elongation by RNA Polymerase I and rRNA Processing by Schneider, D. A., French, S. L., Osheim, Y. N., Bailey, A. O., Vu, L., Dodd, J., Yates, J. R., Beyer, A. L., Nomura, M.

“…Previous investigations into the mechanisms that control RNA Polymerase (Pol) I transcription have primarily focused on the process of transcription…”
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Historical perspective on the use of animal bioassays to predict carcinogenicity: Evolution in design and recognition of utility by Beyer, L. A., Beck, B. D., Lewandowski, T. A.

“…The animal testing protocols used today to evaluate the carcinogenicity of chemicals are very different from those used in the earlier part of the 20th…”
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Splice site selection, rate of splicing, and alternative splicing on nascent transcripts by BEYER, A. L, OSHEIM, Y. N

“…Based on ultrastructural analysis of actively transcribing genes seen in electron micrographs, we present evidence that pre-mRNA splicing occurs with a…”
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Transcription and Translation are Coupled in Archaea by French, Sarah L., Santangelo, Thomas J., Beyer, Ann L., Reeve, John N.

“…Polysomes have been visualized by electron microscopy attached directly to dispersed strands of genomic DNA extruded from lysed cells of the hyperthermophilic…”
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Chromosome structure: DNA nucleotide sequence elements of a subset of the minichromosomes of the protozoan Trypanosoma brucei by WEIDEN, M, OSHEIM, Y. N, BEYER, A. L, VAN DER PLOEG, L. H. T

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Impaired intracellular signal transduction in gastric smooth muscle of diabetic BB/W rats by Takahashi, T, Kojima, Y, Tsunoda, Y, Beyer, L A, Kamijo, M, Sima, A A, Owyang, C

“…The pathophysiological mechanisms responsible for diabetic gastroparesis remain unclear. Diabetes mellitus occurs spontaneously in 90% of a partially inbred…”
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Heterogeneous nuclear ribonucleoprotein complexes and proteins in Drosophila melanogaster by RAYCHAUDHURI, G, HAYNES, S. R, BEYER, A. L

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Independent Deposition of Heterogeneous Nuclear Ribonucleoproteins and Small Nuclear Ribonucleoprotein Particles at Sites of Transcription by Amero, Sally A., Raychaudhuri, Gopa, Cass, Cynthia L., van Venrooij, Walther J., Habets, Winand J., Krainer, Adrian R., Beyer, Ann L.

“…The major nuclear ribonucleoproteins (RNPs) involved in pre-mRNA processing are classified in broad terms either as small nuclear RNPs (snRNPs), which are…”
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Visualization of Drosophila melanogaster chorion genes undergoing amplification by OSHEIM, Y. N, MILLER, O. L. JR, BEYER, A. L

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Exon skipping by overexpression of a Drosophila heterogeneous nuclear ribonucleoprotein in vivo by Shen, J, Zu, K, Cass, C.L, Beyer, A.L, Hirsh, J

“…Heterogeneous nuclear ribonucleoproteins (hnRNPs) are abundant RNA-binding proteins that are implicated in splicing regulation. Here we investigate the role of…”
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RNP particles at splice junction sequences on Drosophila chorion transcripts by Osheim, Y N, Miller, Jr, O L, Beyer, A L

“…HnRNP particles are located at specific sites on nascent transcripts when chromatin is spread for electron microscopic visualization. To determine if the…”
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A unique ribonucleoprotein complex assembles preferentially on ecdysone-responsive sites in Drosophila melanogaster by Amero, S A, Matunis, M J, Matunis, E L, Hockensmith, J W, Raychaudhuri, G, Beyer, A L

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EM Visualization of Transcription by RNA Polymerase II: Downstream Termination Requires a Poly(A) Signal but Not Transcript Cleavage by Osheim, Yvonne N, Proudfoot, Nick J, Beyer, Ann L

“…We have used EM visualization of active genes on plasmid vectors in Xenopus oocyte nuclei to investigate the relationship between poly(A) signals and RNA…”
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The Drosophila Hrb98DE locus encodes four protein isoforms homologous to the A1 protein of mammalian heterogeneous nuclear ribonucleoprotein complexes by HAYNES, S. R, RAYCHAUDHURI, G, BEYER, A. L

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Two Drosophila chorion genes terminate transcription in discrete regions near their poly(A) sites by Osheim, Y.N., Miller, O.L., Beyer, A.L.

“…We have examined transcription termination of two closely linked Drosophila melanogaster chorion genes, s36‐1 and s38‐1, using the electron microscope. Our…”
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Electron microscopy of ribonucleoprotein complexes on nascent RNA using Miller chromatin spreading method by Osheim, Y N, Beyer, A L

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Severe vestibular and auditory impairment in three alleles of Ames waltzer (av) mice by RAPHAEL, Yehoash, KOBAYASHI, Karen N, DOOTZ, Gary A, BEYER, Lisa A, DOLAN, David F, BURMEISTER, Margit

“…The genetic and physiological characterization of circling, hearing-impaired mouse mutants has greatly facilitated our understanding of non-syndromic…”
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microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation by Rudnicki, Anya, Shivatzki, Shaked, Beyer, Lisa A, Takada, Yohei, Raphael, Yehoash, Avraham, Karen B

“…microRNAs (miRNAs) are regulators of differentiation and development of inner ear cells. Mutations in miRNAs lead to deafness in humans and mice. Among inner…”
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