Search Results - "Beyer, Carl F"

Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia by Hamann, Philip R, Hinman, Lois M, Hollander, Irwin, Beyer, Carl F, Lindh, Delores, Holcomb, Ryan, Hallett, William, Tsou, Hwei-Ru, Upeslacis, Janis, Shochat, Dan, Mountain, Andrew, Flowers, David A, Bernstein, Irwin

“…CD33 is expressed by acute myeloid leukemia (AML) cells in >80% of patients but not by normal hematopoietic stem cells, suggesting that elimination of CD33+…”
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Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3- d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells by Jennings, Lee D., Kincaid, Scott L., Wang, Yanong D., Krishnamurthy, Girija, Beyer, Carl F., McGinnis, John P., Miranda, Miriam, Discafani, Carolyn M., Rabindran, Sridhar K.

“…A novel series of anti-proliferative agents containing the thieno[2,3- d]pyrimidin-4-one scaffold and the structure–activity relationship studies to improve…”
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microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties by Beyer, Carl F, Zhang, Nan, Hernandez, Richard, Vitale, Danielle, Nguyen, Thai, Ayral-Kaloustian, Semiramis, Gibbons, James J

“…Purpose To compare TTI-237 (5-chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-[1, 2,…”
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TTI-237 : A Novel Microtubule-Active Compound with In vivo Antitumor Activity by BEYER, Carl F, NAN ZHANG, HERNANDEZ, Richard, VITALE, Danielle, LUCAS, Judy, NGUYEN, Thai, DISCAFANI, Carolyn, AYRAL-KALOUSTIAN, Semiramis, GIBBONS, James J

“…5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine butanedioate…”
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An Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia. Choice of Linker by Hamann, Philip R, Hinman, Lois M, Beyer, Carl F, Lindh, Delores, Upeslacis, Janis, Flowers, David A, Bernstein, Irwin

“…The anti-CD33 antibody, P67.6, has been chosen to target the potently cytotoxic calicheamicin antitumor antibiotics to acute myeloid leukemia (AML) due to the…”
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An Anti-MUC1 Antibody−Calicheamicin Conjugate for Treatment of Solid Tumors. Choice of Linker and Overcoming Drug Resistance by Hamann, Philip R, Hinman, Lois M, Beyer, Carl F, Greenberger, Lee M, Lin, Clara, Lindh, Delores, Menendez, Ana T, Wallace, Rosalyn, Durr, Frederick E, Upeslacis, Janis

“…The anti-MUC1 antibody, CTM01, has been chosen to target the potently cytotoxic calicheamicin antitumor antibiotics to solid tumors of epithelial origin that…”
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A Calicheamicin Conjugate with a Fully Humanized Anti-MUC1 Antibody Shows Potent Antitumor Effects in Breast and Ovarian Tumor Xenografts by Hamann, Philip R, Hinman, Lois M, Beyer, Carl F, Lindh, Delores, Upeslacis, Janis, Shochat, Dan, Mountain, Andrew

“…Murine CTM01 is an internalizing murine IgG1 monoclonal antibody that recognizes the MUC1 antigen expressed on many solid tumors of epithelial origin…”
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Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment by YAMASHITA, Ayako, NORTON, Emily B, ZASK, Arie, AYRAL-KALOUSTIAN, Semiramis, KAPLAN, Joshua A, CHUAN NIU, LOGANZO, Frank, HERNANDEZ, Richard, BEYER, Carl F, ANNABLE, Tami, MUSTO, Sylvia, DISCAFANI, Carolyn

“…Analogs of hemiasterlin (1) and HTI-286 (2), which contain various aromatic rings in the A segment, were synthesized as potential inhibitors of tubulin…”
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A 'dot-immunobinding assay' on nitrocellulose membrane for the determination of the immunoglobulin class of mouse monoclonal antibodies by Beyer, C F

“…A rapid and convenient procedure for the determination of the immunoglobulin class of mouse monoclonal antibodies is described. Hybridoma supernatants or other…”
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Studies of individual amino acid residues of the decapeptide tyrocidine A by proton double-resonance difference spectroscopy in the correlation mode by Gibbons, William A, Beyer, Carl F, Dadok, Josef, Sprecher, Richard F, Wyssbrod, Herman R

“…The cyclic decapeptide antibiotic tyrocidine A was studied by two relatively new methods, viz., correlation proton magnetic resonance (pmr) spectroscopy and…”
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Interaction of the fluorescent probe 2-p-toluidinylnaphthalene-6-sulfonate with peptides. Structural requirements for binding and fluorescence enhancement by Beyer, Carl F, Craig, Lyman C, Gibbons, William A

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Heterogeneous Tryptophan Environments in the Cyclic Peptides Tyrocidines B and C by Beyer, Carl F., Gibbons, William A., Craig, Lyman C., Longworth, James W.

“…Phosphorescence spectroscopy has been used to probe the microenvironments of the tryptophan residues of the cyclic antibiotic decapeptides tyrocidine B (which…”
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Lymphocyte Transformation Induced by Chemical Modification of Membrane Components by Beyer, Carl F., Bowers, William E.

“…Abstract Neuraminidase treatment of responder cells in indirect periodate or indirect neuraminidase-galactose oxidase (NGO) stimulation of rat lymph node cells…”
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Rat Dendritic Cells Function as Accessory Cells and Control the Production of a Soluble Factor Required for Mitogenic Responses of T Lymphocytes by Wolfgang E. F. Klinkert, LaBadie, Jon H., O'Brien, James P., Beyer, Carl F., Bowers, William E.

“…Transformation of T lymphocytes, induced by treatment with periodate or with neuraminidase plus galactose oxidase, requires the participation of accessory…”
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Lymphocyte Transformation Induced by Chemical Modification of Membrane Components by Beyer, Carl F., Bowers, William E.

“…Abstract Reliable culture conditions and a valid 3H-thymidine labeling procedure were established for studies on the in vitro response of rat lymph node cells…”
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Lymphocyte Transformation Induced by Chemical Modification of Membrane Components: II. Effect of Neuraminidase Treatment of Responder Cells on Proliferation and Cytotoxicity in Indirect Stimulation by Beyer, Carl F, Bowers, William E

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Lymphocyte Transformation Induced by Chemical Modification of Membrane Components: I. Characteristics of the Direct and Indirect Restimulation Responses of Rat Lymph Node Cells to Periodate by Beyer, Carl F, Bowers, William E

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Periodate and Concanavalin A Induce Blast Transformation of Rat Lymphocytes by an Indirect Mechanism by Beyer, Carl F., Bowers, William E.

“…When rat lymph node cells, rendered incapable of division by treatment with mitomycin C, were then reacted with sodium metaperiodate (NaIO4), they stimulated…”
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Cell-cell interactions in blast transformation of rat lymphocytes by neuraminidase and galactose oxidase by Kielian, M C, Beyer, C F, Bowers, W E

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