Search Results - "Bevins, Charles L."

Paneth cells: maestros of the small intestinal crypts by Clevers, Hans C, Bevins, Charles L

“…Paneth cells are highly specialized epithelial cells of the small intestine, where they coordinate many physiological functions. First identified more than a…”
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Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis by Salzman, Nita H, Bevins, Charles L

“…Key Points The intestinal microbiota is important for many physiological functions and contributes to host defence by providing resistance to colonization by…”
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An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function by Nyström, Elisabeth E L, Martinez-Abad, Beatriz, Arike, Liisa, Birchenough, George M H, Nonnecke, Eric B, Castillo, Patricia A, Svensson, Frida, Bevins, Charles L, Hansson, Gunnar C, Johansson, Malin E V

“…The intestinal mucus layer, an important element of epithelial protection, is produced by goblet cells. Intestinal goblet cells are assumed to be a homogeneous…”
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Flagella at the Host-Microbe Interface: Key Functions Intersect With Redundant Responses by Akahoshi, Douglas T, Bevins, Charles L

“…Many bacteria and other microbes achieve locomotion flagella, which are organelles that function as a swimming motor. Depending on the environment, flagellar…”
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Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota by Underwood, Mark A., Arriola, Jennifer, Gerber, Colin W., Kaveti, Ashwini, Kalanetra, Karen M., Kananurak, Anchasa, Bevins, Charles L., Mills, David A., Dvorak, Bohuslav

“…Background: Probiotics decrease the risk of necrotizing enterocolitis (NEC). We sought to determine the impact of Bifidobacterium longum subsp. infantis ( B…”
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Extensive in vivo Human Milk Peptidomics Reveals Specific Proteolysis Yielding Protective Antimicrobial Peptides by Dallas, David C, Guerrero, Andres, Khaldi, Nora, Castillo, Patricia A, Martin, William F, Smilowitz, Jennifer T, Bevins, Charles L, Barile, Daniela, German, J. Bruce, Lebrilla, Carlito B

“…Milk is traditionally considered an ideal source of the basic elemental nutrients required by infants. More detailed examination is revealing that milk…”
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Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa by Salzman, Nita H, Underwood, Mark A, Bevins, Charles L

“…Abstract Mucosal surfaces are colonized by a diverse and dynamic microbiota. Much investigation has focused on bacterial colonization of the intestine, home to…”
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Flagella-driven motility is a target of human Paneth cell defensin activity by Akahoshi, Douglas T, Natwick, Dean E, Yuan, Weirong, Lu, Wuyuan, Collins, Sean R, Bevins, Charles L

“…In the mammalian intestine, flagellar motility can provide microbes competitive advantage, but also threatens the spatial segregation established by the host…”
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T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium by Ramirez, Valerie T, Godinez, Dayn R, Brust-Mascher, Ingrid, Nonnecke, Eric B, Castillo, Patricia A, Gardner, Mariana Barboza, Tu, Diane, Sladek, Jessica A, Miller, Elaine N, Lebrilla, Carlito B, Bevins, Charles L, Gareau, Melanie G, Reardon, Colin

“…The regulation of mucosal immune function is critical to host protection from enteric pathogens but is incompletely understood. The nervous system and the…”
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Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum by Biswas, Amlan, Liu, Yuen-Joyce, Hao, Liming, Mizoguchi, Atsushi, Salzman, Nita H., Bevins, Charles L., Kobayashi, Koichi S., Glimcher, Laurie H.

“…Mutations in the NOD2 gene are strong genetic risk factors for ileal Crohn's disease. However, the mechanism by which these mutations predispose to intestinal…”
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Editorial: Advances in the Immunology of Host Defense Peptide: Mechanisms and Applications of Antimicrobial Functions and Beyond by Phan, Thanh Kha, Bevins, Charles L, Hulett, Mark D

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Salmonella uses energy taxis to benefit from intestinal inflammation by Rivera-Chávez, Fabian, Winter, Sebastian E, Lopez, Christopher A, Xavier, Mariana N, Winter, Maria G, Nuccio, Sean-Paul, Russell, Joseph M, Laughlin, Richard C, Lawhon, Sara D, Sterzenbach, Torsten, Bevins, Charles L, Tsolis, Renée M, Harshey, Rasika, Adams, L Garry, Bäumler, Andreas J

“…Chemotaxis enhances the fitness of Salmonella enterica serotype Typhimurium (S. Typhimurium) during colitis. However, the chemotaxis receptors conferring this…”
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Reduced Paneth Cell α-Defensins in Ileal Crohn's Disease by Jan Wehkamp, Salzman, Nita H., Edith Porter, Sabine Nuding, Michael Weichenthal, Robert E. Petras, Shen, Bo, Elke Schaeffeler, Matthias Schwab, Rose Linzmeier, Ryan W. Feathers, Hiutung Chu, Heriberto Lima, Jr, Klaus Fellermann, Ganz, Tomas, Stange, Eduard F., Bevins, Charles L.

“…The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and…”
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Characterization of an intelectin-1 ( Itln1 ) knockout mouse model by Nonnecke, Eric B, Castillo, Patricia A, Akahoshi, Douglas T, Goley, Stephanie M, Bevins, Charles L, Lönnerdal, Bo

“…Intelectins are carbohydrate-binding proteins implicated in innate immunity and highly conserved across chordate evolution, including both ascidians and…”
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Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin by Bevins, Charles L, Salzman, Nita H, Ghosh, Dipankar, Huttner, Kenneth M, Paterson, Yvonne

“…Genetically encoded antibiotic peptides are evolutionarily ancient and widespread effector molecules of immune defence. Mammalian defensins, one subset of such…”
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An Experimental Approach to Rigorously Assess Paneth Cell α-Defensin (Defa) mRNA Expression in C57BL/6 Mice by Castillo, Patricia A., Nonnecke, Eric B., Ossorio, Daniel T., Tran, Michelle T. N., Goley, Stephanie M., Lönnerdal, Bo, Underwood, Mark A., Bevins, Charles L.

“…Abundant evidence from many laboratories supports the premise that α-defensin peptides secreted from Paneth cells are key mediators of host-microbe…”
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Extensive variation in the intelectin gene family in laboratory and wild mouse strains by Almalki, Faisal, Nonnecke, Eric B., Castillo, Patricia A., Bevin-Holder, Alex, Ullrich, Kristian K., Lönnerdal, Bo, Odenthal-Hesse, Linda, Bevins, Charles L., Hollox, Edward J.

“…Intelectins are a family of multimeric secreted proteins that bind microbe-specific glycans. Both genetic and functional studies have suggested that…”
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Human intelectin-1 (ITLN1) genetic variation and intestinal expression by Nonnecke, Eric B., Castillo, Patricia A., Dugan, Amanda E., Almalki, Faisal, Underwood, Mark A., De La Motte, Carol A., Yuan, Weirong, Lu, Wuyuan, Shen, Bo, Johansson, Malin E. V., Kiessling, Laura L., Hollox, Edward J., Lönnerdal, Bo, Bevins, Charles L.

“…Intelectins are ancient carbohydrate binding proteins, spanning chordate evolution and implicated in multiple human diseases. Previous GWAS have linked SNPs in…”
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Human alpha defensin 5 expression in the human kidney and urinary tract by Spencer, John David, Hains, David S, Porter, Edith, Bevins, Charles L, DiRosario, Julianne, Becknell, Brian, Wang, Huanyu, Schwaderer, Andrew L

“…The mechanisms that maintain sterility in the urinary tract are incompletely understood. Recent studies have implicated the importance of antimicrobial…”
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Routine habitat change: a source of unrecognized transient alteration of intestinal microbiota in laboratory mice by Ma, Betty W, Bokulich, Nicholas A, Castillo, Patricia A, Kananurak, Anchasa, Underwood, Mark A, Mills, David A, Bevins, Charles L

“…The mammalian intestine harbors a vast, complex and dynamic microbial population, which has profound effects on host nutrition, intestinal function and immune…”
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