Search Results - "Beverley, M."

Protein Lysine Acetylation by p300/CBP by Dancy, Beverley M, Cole, Philip A

“…The role of p300/CBP in protein lysine acetylation is examined. The inhibitors of p300 acetyltransferase activity and the protein ligands of p300/CBP are among…”
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The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes by Liu, Fan, Lössl, Philip, Rabbitts, Beverley M., Balaban, Robert S., Heck, Albert J.R.

“…Mitochondria exert an immense amount of cytophysiological functions, but the structural basis of most of these processes is still poorly understood. Here we…”
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The psychosocial cost burden of cancer: A systematic literature review by Essue, Beverley M., Iragorri, Nicolas, Fitzgerald, Natalie, de Oliveira, Claire

“…Background and Objective Psychosocial costs, or quality of life costs, account for psychological distress, pain, suffering and other negative experiences…”
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Action to address the household economic burden of non-communicable diseases by Jan, Stephen, Laba, Tracey-Lea, Essue, Beverley M, Gheorghe, Adrian, Muhunthan, Janani, Engelgau, Michael, Mahal, Ajay, Griffiths, Ulla, McIntyre, Diane, Meng, Qingyue, Nugent, Rachel, Atun, Rifat

“…The economic burden on households of non-communicable diseases (NCDs), including cardiovascular diseases, cancer, respiratory diseases, and diabetes, poses…”
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Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank by Thomas, Nicholas J, Jones, Samuel E, Weedon, Michael N, Shields, Beverley M, Oram, Richard A, Hattersley, Andrew T

“…Type 1 diabetes is typically considered a disease of children and young adults. Genetic susceptibility to young-onset type 1 diabetes is well defined and does…”
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Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients by Shields, Beverley M, Shepherd, Maggie, Hudson, Michelle, McDonald, Timothy J, Colclough, Kevin, Peters, Jaime, Knight, Bridget, Hyde, Chris, Ellard, Sian, Pearson, Ewan R, Hattersley, Andrew T

“…Monogenic diabetes, a young-onset form of diabetes, is often misdiagnosed as type 1 diabetes, resulting in unnecessary treatment with insulin. A screening…”
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Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data by Dennis, John M, Shields, Beverley M, Henley, William E, Jones, Angus G, Hattersley, Andrew T

“…Research using data-driven cluster analysis has proposed five subgroups of diabetes with differences in diabetes progression and risk of complications. We…”
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A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans by Koopman, Mandy, Michels, Helen, Dancy, Beverley M, Kamble, Rashmi, Mouchiroud, Laurent, Auwerx, Johan, Nollen, Ellen A A, Houtkooper, Riekelt H

“…Mitochondrial dysfunction is linked to a range of common disorders, including inherited metabolic diseases, diabetes and cancer. Here, Koopman et al. describe…”
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Dirichlet process mixture models to impute missing predictor data in counterfactual prediction models: an application to predict optimal type 2 diabetes therapy by Cardoso, Pedro, Dennis, John M, Bowden, Jack, Shields, Beverley M, McKinley, Trevelyan J

“…The handling of missing data is a challenge for inference and regression modelling. A particular challenge is dealing with missing predictor information,…”
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Chronobiology of Parkinson's disease: Past, present and future by Asadpoordezaki, Ziba, Coogan, Andrew N., Henley, Beverley M.

“…Parkinson's disease is a neurodegenerative disorder predominately affecting midbrain dopaminergic neurons that results in a broad range of motor and non‐motor…”
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Prevalence of Vascular Complications Among Patients With Glucokinase Mutations and Prolonged, Mild Hyperglycemia by Steele, Anna M, Shields, Beverley M, Wensley, Kirsty J, Colclough, Kevin, Ellard, Sian, Hattersley, Andrew T

“…IMPORTANCE Glycemic targets in diabetes have been developed to minimize complication risk. Patients with heterozygous, inactivating glucokinase (GCK) mutations…”
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Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes by Jones, Angus G, McDonald, Timothy J, Shields, Beverley M, Hagopian, William, Hattersley, Andrew T

“…Latent autoimmune diabetes of adults (LADA) is typically defined as a new diabetes diagnosis after 35 years of age, presenting with clinical features of type 2…”
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Gender equity, caregiving, and the 1-2-3-child policy in China by Kwete, Xiaoxiao, Knaul, Felicia Marie, Essue, Beverley M, Langer, Ana

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Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study by Shields, Beverley M., Dennis, John M., Angwin, Catherine D., Warren, Fiona, Henley, William E., Farmer, Andrew J., Sattar, Naveed, Holman, Rury R., Jones, Angus G., Pearson, Ewan R., Hattersley, Andrew T.

“…Precision medicine aims to treat an individual based on their clinical characteristics. A differential drug response, critical to using these features for…”
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C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase by Shields, Beverley M, McDonald, Timothy J, Oram, Richard, Hill, Anita, Hudson, Michelle, Leete, Pia, Pearson, Ewan R, Richardson, Sarah J, Morgan, Noel G, Hattersley, Andrew T

“…The decline in C-peptide in the 5 years after diagnosis of type 1 diabetes has been well studied, but little is known about the longer-term trajectory. We…”
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Universal health coverage must become a best buy for women by Knaul, Felicia Marie, Essue, Beverley M, Arreola-Ornelas, Héctor, Watkins, David, Langer, Ana

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Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population by Knight, Bridget Ann, Shields, Beverley M, Brook, Adam, Hill, Anita, Bhat, Dattatray S, Hattersley, Andrew T, Yajnik, Chittaranjan S

“…Vitamin B12 and folate are critical micronutrients needed to support the increased metabolic demands of pregnancy. Recent studies from India have suggested…”
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Glycated haemoglobin measurements from UK Biobank are different to those in linked primary care records: implications for combining biochemistry data from research studies and routine clinical care by Young, Katherine G, McDonald, Timothy J, Shields, Beverley M

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Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis by Leete, Pia, Oram, Richard A., McDonald, Timothy J., Shields, Beverley M., Ziller, Clemens, Hattersley, Andrew T., Richardson, Sarah J., Morgan, Noel G.

“…Aims/hypothesis It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples…”
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A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin by Shepherd, Maggie H., Shields, Beverley M., Hudson, Michelle, Pearson, Ewan R., Hyde, Christopher, Ellard, Sian, Hattersley, Andrew T., Patel, Kashyap A.

“…Aims/hypothesis Treatment change following a genetic diagnosis of MODY is frequently indicated, but little is known about the factors predicting future…”
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