Search Results - "Bevan, P."

Estrogen controls the survival of BRCA1-deficient cells via a PI3K–NRF2-regulated pathway by Gorrini, Chiara, Gang, Bevan P., Bassi, Christian, Wakeham, Andrew, Baniasadi, Shakiba Pegah, Hao, Zhenyue, Li, Wanda Y., Cescon, David W., Li, Yen-Ting, Molyneux, Sam, Penrod, Nadia, Lupien, Mathieu, Schmidt, Edward E., Stambolic, Vuk, Gauthier, Mona L., Mak, Tak W.

“…Mutations in the tumor suppressor BRCA1 predispose women to breast and ovarian cancers. The mechanism underlying the tissue-specific nature of BRCA1's tumor…”
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Take It or Levo It: An Updated Look at the Use of Levosimendan to Prevent Low Cardiac Output Syndrome in Pediatric Patients by Staudt, Genevieve E., Londergan, Bevan P., Eagle, Susan S.

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What an anesthesiologist should know about pediatric arrhythmias by Kuntz, Michael T., Eagle, Susan S., Dalal, Aarti, Samouil, Marc M., Staudt, Genevieve E., Londergan, Bevan P.

“…Identifying and treating pediatric arrhythmias is essential for pediatric anesthesiologists. Pediatric patients can present with narrow or wide complex…”
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Insulin signalling by Bevan, P

“…ABSTRACT Insulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor…”
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Accounting for the Impact of Conservation on Human Well‐Being by MILNER‐GULLAND, E.J, MCGREGOR, J.A, AGARWALA, M, ATKINSON, G, BEVAN, P, CLEMENTS, T, DAW, T, HOMEWOOD, K, KUMPEL, N, LEWIS, J, MOURATO, S, PALMER FRY, B, REDSHAW, M, ROWCLIFFE, J.M, SUON, S, WALLACE, G, WASHINGTON, H, WILKIE, D

“…Conservationists are increasingly engaging with the concept of human well‐being to improve the design and evaluation of their interventions. Since the…”
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Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer by Heinemann, V, Ebert, M P, Laubender, R P, Bevan, P, Mala, C, Boeck, S

“…Background: To evaluate the efficacy and tolerability of the urokinase plasminogen activator (uPA) inhibitor upamostat in combination with gemcitabine in…”
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Facilitating Collaboration in Rare Genetic Disorders Through Effective Matchmaking in DECIPHER by Chatzimichali, Eleni A., Brent, Simon, Hutton, Benjamin, Perrett, Daniel, Wright, Caroline F., Bevan, Andrew P., Hurles, Matthew E., Firth, Helen V., Swaminathan, Ganesh J.

“…ABSTRACT DECIPHER (https://decipher.sanger.ac.uk) is a web‐based platform for secure deposition, analysis, and sharing of plausibly pathogenic genomic variants…”
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Targeting of two aspects of metabolism in breast cancer treatment by Gang, Bevan P, Dilda, Pierre J, Hogg, Phillip J, Blackburn, Anneke C

“…Deregulated metabolism is gaining recognition as a hallmark of cancer cells, and is being explored for therapeutic potential. The Warburg effect is a metabolic…”
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Ensembl 2002: accommodating comparative genomics by Clamp, M., Andrews, D., Barker, D., Bevan, P., Cameron, G., Chen, Y., Clark, L., Cox, T., Cuff, J., Curwen, V., Down, T., Durbin, R., Eyras, E., Gilbert, J., Hammond, M., Hubbard, T., Kasprzyk, A., Keefe, D., Lehvaslaiho, H., Iyer, V., Melsopp, C., Mongin, E., Pettett, R., Potter, S., Rust, A., Schmidt, E., Searle, S., Slater, G., Smith, J., Spooner, W., Stabenau, A., Stalker, J., Stupka, E., Ureta-Vidal, A., Vastrik, I., Birney, E.

“…The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organise biology around the sequences of large genomes. It is a…”
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In vitro characterization of the subharmonic ultrasound signal from Definity microbubbles at high frequencies by Cheung, K, Couture, O, Bevan, P D, Cherin, E, Williams, R, Burns, P N, Foster, F S

“…Ultrasound microbubble contrast agents have been demonstrated to scatter subharmonic energy at one-half the driving frequency. At ultrasound frequencies in the…”
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Ensembl 2004 by Birney, E., Andrews, D., Bevan, P., Caccamo, M., Cameron, G., Chen, Y., Clarke, L., Coates, G., Cox, T., Cuff, J., Curwen, V., Cutts, T., Down, T., Durbin, R., Eyras, E., Fernandez‐Suarez, X. M., Gane, P., Gibbins, B., Gilbert, J., Hammond, M., Hotz, H., Iyer, V., Kahari, A., Jekosch, K., Kasprzyk, A., Keefe, D., Keenan, S., Lehvaslaiho, H., McVicker, G., Melsopp, C., Meidl, P., Mongin, E., Pettett, R., Potter, S., Proctor, G., Rae, M., Searle, S., Slater, G., Smedley, D., Smith, J., Spooner, W., Stabenau, A., Stalker, J., Storey, R., Ureta‐Vidal, A., Woodwark, C., Clamp, M., Hubbard, T.

“…The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organize biology around the sequences of large genomes. It is a…”
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Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus by Stadler, Nadina, Heeneman, Sylvia, Vöö, Stefan, Stanley, Naomi, Giles, Gregory I, Gang, Bevan P, Croft, Kevin D, Mori, Trevor A, Vacata, Vladimir, Daemen, Mat J.A.P, Waltenberger, Johannes, Davies, Michael J

“…Highlights ► Elevated levels of metal ions have been proposed as catalysts in atherosclerosis. ► Lesions from people with and without Type 2 diabetes were…”
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The Molecular Design of S-Nitrosothiols as Photodynamic Agents for Controlled Nitric Oxide Release by Giles, Niroshini M., Kumari, Sweta, Gang, Bevan P., Yuen, Chun W. W., Billaud, Emilie M. F., Giles, Gregory I.

“…Nitric oxide is a small messenger molecule utilized by nature in cell signalling and the non‐specific immune response. At present, nitric oxide releasing…”
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DECIPHER: web-based, community resource for clinical interpretation of rare variants in developmental disorders by SWAMINATHAN, Ganesh J, BRAGIN, Eugene, CHATZIMICHALI, Eleni A, CORPAS, Manuel, BEVAN, A. Paul, WRIGHT, Caroline F, CARTER, Nigel P, HURLES, Matthew E, FIRTH, Helen V

“…Patients with developmental disorders often harbour sub-microscopic deletions or duplications that lead to a disruption of normal gene expression or…”
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DECIPHER: Supporting the interpretation and sharing of rare disease phenotype‐linked variant data to advance diagnosis and research by Foreman, Julia, Brent, Simon, Perrett, Daniel, Bevan, Andrew P., Hunt, Sarah E., Cunningham, Fiona, Hurles, Matthew E., Firth, Helen V.

“…DECIPHER (https://www.deciphergenomics.org) is a free web platform for sharing anonymized phenotype‐linked variant data from rare disease patients. Its dynamic…”
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Talocalcaneal Tarsal Coalitions and the Calcaneal Lengthening Osteotomy: The Role of Deformity Correction by Mosca, Vincent S, Bevan, Wesley P

“…BACKGROUND:Surgical resection of persistently painful talocalcaneal tarsal coalitions may not reliably relieve symptoms in patients with large coalitions…”
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Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics by POSNER, B. I, FAURE, R, SHAVER, A, BURGESS, J. W, BEVAN, A. P, LACHANCE, D, GUIYI ZHANG-SUN, FANTUS, I. G, NG, J. B, HALL, D. A, SOO LUM, B

“…Twelve peroxovanadium (pV) compounds, each containing an oxo ligand, one or two peroxo anions, and an ancillary ligand in the inner coordination sphere of V,…”
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Weight-Bearing in the Nonoperative Treatment of Acute Achilles Tendon Ruptures: A Randomized Controlled Trial by Young, Simon W, Patel, Alpesh, Zhu, Mark, van Dijck, Stephanie, McNair, Peter, Bevan, Wesley P, Tomlinson, Matthew

“…BACKGROUND:The rate of Achilles tendon ruptures is increasing, but there is a lack of consensus on treatment of acute injuries. The purpose of this trial was…”
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Weight-Bearing in the Nonoperative Treatment of Acute Achilles Tendon Ruptures by Young, Simon W, Patel, Alpesh, Zhu, Mark, van Dijck, Stephanie, McNair, Peter, Bevan, Wesley P, Tomlinson, Matthew

“…Background:The rate of Achilles tendon ruptures is increasing, but there is a lack of consensus on treatment of acute injuries. The purpose of this trial was…”
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Emergency First Responders and Professional Wellbeing: A Qualitative Systematic Review by Bevan, Malcolm P, Priest, Sally J, Plume, Ruth C, Wilson, Emma E

“…Emergency first responders (EFRs) such as police officers, firefighters, paramedics and logistics personnel often suffer high turnover due to work-related…”
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