Search Results - "Bevan, L."

Breaking down walls in prostate cancer with the MURAL collection of patient-derived xenografts by Bevan, Charlotte L.

“…A bank of 59 well-characterised prostate cancer patient-derived xenografts was established, including 17 classed as research-ready covering the…”
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Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum by Cai, Shenglin, Pataillot-Meakin, Thomas, Shibakawa, Akifumi, Ren, Ren, Bevan, Charlotte L., Ladame, Sylvain, Ivanov, Aleksandar P., Edel, Joshua B.

“…MicroRNAs (miRNAs) play essential roles in post-transcriptional gene expression and are also found freely circulating in bodily fluids such as blood…”
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MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data by Rana, Sharmila, Valbuena, Gabriel N., Curry, Ed, Bevan, Charlotte L., Keun, Hector C.

“…Background Reliable prognostic biomarkers to distinguish indolent from aggressive prostate cancer (PCa) are lacking. Many studies investigated microRNAs (miRs)…”
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Circulating microRNAs as potential new biomarkers for prostate cancer by Sita-Lumsden, A, Dart, D A, Waxman, J, Bevan, C L

“…Since they were first described in the 1990s, circulating microRNAs (miRNAs) have provided an active and rapidly evolving area of current research that has the…”
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Strong Ocean Melting Feedback During the Recent Retreat of Thwaites Glacier by Holland, Paul R., Bevan, Suzanne L., Luckman, Adrian J.

“…Accelerating ice loss from Thwaites Glacier is contributing approximately 5% of global sea‐level rise, and could add tens of centimeters to sea level over the…”
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Light-triggered enzymatic reactions in nested vesicle reactors by Hindley, James W., Elani, Yuval, McGilvery, Catriona M., Ali, Simak, Bevan, Charlotte L., Law, Robert V., Ces, Oscar

“…Cell-sized vesicles have tremendous potential both as miniaturised pL reaction vessels and in bottom-up synthetic biology as chassis for artificial cells. In…”
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Building a synthetic mechanosensitive signaling pathway in compartmentalized artificial cells by Hindley, James W., Zheleva, Daniela G., Elani, Yuval, Charalambous, Kalypso, Barter, Laura M. C., Booth, Paula J., Bevan, Charlotte L., Law, Robert V., Ces, Oscar

“…To date, reconstitution of one of the fundamental methods of cell communication, the signaling pathway, has been unaddressed in the bottom-up construction of…”
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Deep Learning for Ultrasonic Crack Characterization in NDE by Pyle, Richard J., Bevan, Rhodri L. T., Hughes, Robert R., Rachev, Rosen K., Ali, Amine Ait Si, Wilcox, Paul D.

“…Machine learning for nondestructive evaluation (NDE) has the potential to bring significant improvements in defect characterization accuracy due to its…”
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STENCIL-NET for equation-free forecasting from data by Maddu, Suryanarayana, Sturm, Dominik, Cheeseman, Bevan L., Müller, Christian L., Sbalzarini, Ivo F.

“…We present an artificial neural network architecture, termed STENCIL-NET, for equation-free forecasting of spatiotemporal dynamics from data. STENCIL-NET works…”
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The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells by Leach, D. A., Mohr, A., Giotis, E. S., Cil, E., Isac, A. M., Yates, L. L., Barclay, W. S., Zwacka, R. M., Bevan, C. L., Brooke, G. N.

“…SARS-CoV-2 attacks various organs, most destructively the lung, and cellular entry requires two host cell surface proteins: ACE2 and TMPRSS2. Downregulation of…”
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Adaptive particle representation of fluorescence microscopy images by Cheeseman, Bevan L., Günther, Ulrik, Gonciarz, Krzysztof, Susik, Mateusz, Sbalzarini, Ivo F.

“…Modern microscopes create a data deluge with gigabytes of data generated each second, and terabytes per day. Storing and processing this data is a severe…”
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Parallel Discrete Convolutions on Adaptive Particle Representations of Images by Jonsson, Joel, Cheeseman, Bevan L., Maddu, Suryanarayana, Gonciarz, Krzysztof, Sbalzarini, Ivo F.

“…We present data structures and algorithms for native implementations of discrete convolution operators over Adaptive Particle Representations (APR) of images…”
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Analysis of androgen receptor expression and activity in the mouse brain by Dart, D. Alwyn, Bevan, Charlotte L., Uysal-Onganer, Pinar, Jiang, Wen Guo

“…Androgen deprivation therapy (ADT) is the core treatment for advanced prostate cancer (PCa), with a proven survival benefit. ADT lowers circulating…”
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Liver X Receptors and Male (In)fertility by Jarvis, Sheba, Williamson, Catherine, Bevan, Charlotte L

“…Liver X receptors (LXRs) are ligand-dependent transcription factors acting as 'cholesterol sensors' to regulate lipid homeostasis in cells. The two isoforms,…”
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A Model for Multiview Ultrasonic Array Inspection of Small Two-Dimensional Defects by Budyn, Nicolas, Bevan, Rhodri L. T., Zhang, Jie, Croxford, Anthony J., Wilcox, Paul D.

“…The multiview total focusing method (TFM) is an imaging algorithm for ultrasonic full matrix array data that exploits internal reflections and mode conversions…”
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Impact of warming shelf waters on ice mélange and terminus retreat at a large SE Greenland glacier by Bevan, Suzanne L., Luckman, Adrian J., Benn, Douglas I., Cowton, Tom, Todd, Joe

“…By the end of 2018 Kangerlussuaq Glacier in southeast Greenland had retreated further inland than at any time in the past 80 years and its terminus was…”
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Visualising androgen receptor activity in male and female mice by Dart, D Alwyn, Waxman, Jonathan, Aboagye, Eric O, Bevan, Charlotte L

“…Androgens, required for normal development and fertility of males and females, have vital roles in the reproductive tract, brain, cardiovascular system, smooth…”
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Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality by Grieb, Maj Svea, Nivina, Aleksandra, Cheeseman, Bevan L, Hartmann, Andreas, Mazel, Didier, Schlierf, Michael

“…Biologically functional DNA hairpins are found in archaea, prokaryotes and eukaryotes, playing essential roles in various DNA transactions. However, during DNA…”
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Rapid fragmentation of Thwaites Eastern Ice Shelf by Benn, Douglas I, Luckman, Adrian, Ãström, Jan A, Crawford, Anna J, Cornford, Stephen L, Bevan, Suzanne L, Zwinger, Thomas, Gladstone, Rupert, Alley, Karen, Pettit, Erin, Bassis, Jeremy

“…Ice shelves play a key role in the dynamics of marine ice sheets by buttressing grounded ice and limiting rates of ice flux to the oceans. In response to…”
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Androgen-regulated processing of the oncomir MiR-27a, which targets Prohibitin in prostate cancer by FLETCHER, Claire E, DART, D. Alwyn, SITA-LUMSDEN, Ailsa, CHENG, Helen, RENNIE, Paul S, BEAN, Charlotte L

“…MicroRNAs (miRs) play an important role in the development of many complex human diseases and may have tumour suppressor or oncogenic (oncomir) properties…”
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