Search Results - "Bevan, David"

Natural product-based amyloid inhibitors by Velander, Paul, Wu, Ling, Henderson, Frances, Zhang, Shijun, Bevan, David R., Xu, Bin

“…[Display omitted] Many chronic human diseases, including multiple neurodegenerative diseases, are associated with deleterious protein aggregates, also called…”
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Molecular Dynamics Simulations of Amyloid β-Peptide (1-42): Tetramer Formation and Membrane Interactions by Brown, Anne M., Bevan, David R.

“…The aggregation cascade and peptide-membrane interactions of the amyloid β-peptide (Aβ) have been implicated as toxic events in the development and progression…”
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Assessing the Stability of Alzheimer’s Amyloid Protofibrils Using Molecular Dynamics by Lemkul, Justin A, Bevan, David R

“…Amyloid fibrils represent a stable form of many misfolded proteins associated with numerous diseases. Among these are Parkinson’s disease (α-synuclein), Type…”
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Growth rates of permutation grid classes, tours on graphs, and the spectral radius by BEVAN, DAVID

“…Monotone grid classes of permutations have proven very effective in helping to determine structural and enumerative properties of classical permutation pattern…”
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Pegylated, full-length, recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A by Konkle, Barbara A., Stasyshyn, Oleksandra, Chowdary, Pratima, Bevan, David H., Mant, Tim, Shima, Midori, Engl, Werner, Dyck-Jones, Jacqueline, Fuerlinger, Monika, Patrone, Lisa, Ewenstein, Bruce, Abbuehl, Brigitt

“…Current management of hemophilia A includes prophylaxis with factor VIII (FVIII) replacement every 2 to 3 days. BAX 855, Baxalta's pegylated full-length…”
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Study and design of stability in GH5 cellulases by Badieyan, Somayesadat, Bevan, David R., Zhang, Chenming

“…Thermostable enzymes that hydrolyze lignocellulosic materials provide potential advantages in process configuration and enhancement of production efficiency…”
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GridMAT-MD: A grid-based membrane analysis tool for use with molecular dynamics by Allen, William J, Lemkul, Justin A, Bevan, David R

“…GridMAT-MD is a new program developed to aid in the analysis of lipid bilayers from molecular dynamics simulations. It reads a GROMACS coordinate file and…”
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Long-term outcomes of hospital survivors following an ICU stay: A multi-centre retrospective cohort study by Doherty, Zakary, Kippen, Rebecca, Bevan, David, Duke, Graeme, Williams, Sharon, Wilson, Andrew, Pilcher, David

“…The focus of much Intensive Care research has been on short-term survival, which has demonstrated clear improvements over time. Less work has investigated…”
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Practical Considerations for Building GROMOS-Compatible Small-Molecule Topologies by Lemkul, Justin A, Allen, William J, Bevan, David R

“…Molecular dynamics simulations are being applied to increasingly complex systems, including those involving small endogenous compounds and drug molecules. In…”
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A critical evaluation of cryoprecipitate for replacement of fibrinogen by Sørensen, Benny, Bevan, David

“…Summary Maintaining the plasma fibrinogen concentration is important to limit excessive perioperative blood loss. This article considers the evidence for this…”
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Herbivore-induced and floral homoterpene volatiles are biosynthesized by a single P450 enzyme (CYP82G1) in Arabidopsis by Lee, Sungbeom, Badieyan, Somayesadat, Bevan, David R., Herde, Marco, Gatz, Christiane, Tholl, Dorothea, Berenbaum, May R.

“…Terpene volatiles play important roles in plant-organism interactions as attractants of pollinators or as defense compounds against herbivores. Among the most…”
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The permutation class Av(4213,2143) by Bevan, David

“…We determine the structure of permutations avoiding the patterns 4213 and 2143. Each such permutation consists of the skew sum of a sequence of plane trees,…”
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Biophysical insights into OR2T7: Investigation of a potential prognostic marker for glioblastoma by Sharp, Amanda K., Newman, David, Libonate, Gianna, Borns-Stern, Mary, Bevan, David R., Brown, Anne M., Anandakrishnan, Ramu

“…Glioblastoma multiforme (GBM) is the most aggressive and prevalent form of brain cancer, with an expected survival of 12–15 months following diagnosis. GBM…”
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Probing the Active Site Chemistry of β‑Glucosidases along the Hydrolysis Reaction Pathway by Badieyan, Somayesadat, Bevan, David R, Zhang, Chenming

“…β-Glucosidases (EC 3.2.1.21) can be found in all domains of living organisms, where they play essential roles in the removal of terminal glucosyl residues from…”
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Lambda‐PCR for precise DNA assembly and modification by Tanniche, Imen, Fisher, Amanda K., Gillam, Frank, Collakova, Eva, Zhang, Chenming, Bevan, David R., Senger, Ryan S.

“…Lambda‐polymerase chain reaction (λ‐PCR) is a novel and open‐source method for DNA assembly and cloning projects. λ‐PCR uses overlap extension to ultimately…”
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Morin Inhibits the Early Stages of Amyloid β-Peptide Aggregation by Altering Tertiary and Quaternary Interactions to Produce “Off-Pathway” Structures by Lemkul, Justin A, Bevan, David R

“…Alzheimer’s disease is a debilitating neurodegenerative disorder whose pathology has been linked to the aggregation and deposition of the amyloid β-peptide…”
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Molecular evolution of genes encoding allergen proteins in the peanuts genus Arachis: Structural and functional implications by Hilu, Khidir W, Friend, Sheena A, Vallanadu, Viruthika, Brown, Anne M, Hollingsworth, 4th, Louis R, Bevan, David R

“…Food allergies are severe immune responses to plant and animal products mediated by immunoglobulin E (IgE). Peanuts (Arachis hypogaea L.) are among the top 15…”
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Aggregation of Alzheimer’s Amyloid β‑Peptide in Biological Membranes: A Molecular Dynamics Study by Lemkul, Justin A, Bevan, David R

“…Numerous studies have concluded that the interaction of the amyloid β-peptide (Aβ) and cellular membranes contributes to the toxicity and cell death observed…”
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Lipid composition influences the release of Alzheimer's amyloid β‐peptide from membranes by Lemkul, Justin A., Bevan, David R.

“…The behavior of the amyloid β‐peptide (Aβ) within a membrane environment is integral to its toxicity and the progression of Alzheimer's disease. Ganglioside…”
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Curare: from laboratory to law court by Bevan, David R

“…Dr. David Bevan held the Wesley-Bourne Chair of Anesthesia at McGill University, Chair of Anesthesia at UBC, Anesthetist-in-Chief at the University Health…”
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