Search Results - "Bevacqua, Romina J."

Molecular and genetic regulation of pig pancreatic islet cell development by Kim, Seokho, Whitener, Robert L, Peiris, Heshan, Gu, Xueying, Chang, Charles A, Lam, Jonathan Y, Camunas-Soler, Joan, Park, Insung, Bevacqua, Romina J, Tellez, Krissie, Quake, Stephen R, Lakey, Jonathan R T, Bottino, Rita, Ross, Pablo J, Kim, Seung K

“…Reliance on rodents for understanding pancreatic genetics, development and islet function could limit progress in developing interventions for human diseases…”
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CRISPR-based genome editing in primary human pancreatic islet cells by Bevacqua, Romina J., Dai, Xiaoqing, Lam, Jonathan Y., Gu, Xueying, Friedlander, Mollie S. H., Tellez, Krissie, Miguel-Escalada, Irene, Bonàs-Guarch, Silvia, Atla, Goutham, Zhao, Weichen, Kim, Seung Hyun, Dominguez, Antonia A., Qi, Lei S., Ferrer, Jorge, MacDonald, Patrick E., Kim, Seung K.

“…Gene targeting studies in primary human islets could advance our understanding of mechanisms driving diabetes pathogenesis. Here, we demonstrate successful…”
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Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein by Bevacqua, Romina J., Zhao, Weichen, Merheb, Emilio, Kim, Seung Hyun, Marson, Alexander, Gloyn, Anna L., Kim, Seung K.

“…Successful genome editing in primary human islets could reveal features of the genetic regulatory landscape underlying β cell function and diabetes risk. Here,…”
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SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment by Wu, Chien-Ting, Lidsky, Peter V., Xiao, Yinghong, Lee, Ivan T., Cheng, Ran, Nakayama, Tsuguhisa, Jiang, Sizun, Demeter, Janos, Bevacqua, Romina J., Chang, Charles A., Whitener, Robert L., Stalder, Anna K., Zhu, Bokai, Chen, Han, Goltsev, Yury, Tzankov, Alexandar, Nayak, Jayakar V., Nolan, Garry P., Matter, Matthias S., Andino, Raul, Jackson, Peter K.

“…Emerging evidence points toward an intricate relationship between the pandemic of coronavirus disease 2019 (COVID-19) and diabetes. While preexisting diabetes…”
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Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion by Wu, Chien-Ting, Hilgendorf, Keren I, Bevacqua, Romina J, Hang, Yan, Demeter, Janos, Kim, Seung K, Jackson, Peter K

“…Multiple G protein-coupled receptors (GPCRs) are expressed in pancreatic islet cells, but the majority have unknown functions. We observed specific GPCRs…”
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SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells by Bevacqua, Romina J, Lam, Jonathan Y, Peiris, Heshan, Whitener, Robert L, Kim, Seokho, Gu, Xueying, Friedlander, Mollie S H, Kim, Seung K

“…The physiological functions of many vital tissues and organs continue to mature after birth, but the genetic mechanisms governing this postnatal maturation…”
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Pancreatic Pseudoislets: An Organoid Archetype for Metabolism Research by Friedlander, Mollie S H, Nguyen, Vy M, Kim, Seung K, Bevacqua, Romina J

“…Pancreatic islets are vital endocrine regulators of systemic metabolism, and recent investigations have increasingly focused on understanding human islet…”
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RFX6 maintains gene expression and function of adult human islet α cells by Coykendall, Vy M N, Qian, Mollie F, Tellez, Krissie, Bautista, Austin, Bevacqua, Romina J, Gu, Xueying, Hang, Yan, Neukam, Martin, Zhao, Weichen, Chang, Charles, MacDonald, Patrick E, Kim, Seung K

“…Mutations in the gene encoding the transcription factor RFX6 are associated with human diabetes mellitus. Within pancreatic islets, RFX6 expression is most…”
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A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk by Rottner, Antje K., Ye, Yingying, Navarro-Guerrero, Elena, Rajesh, Varsha, Pollner, Alina, Bevacqua, Romina J., Yang, Jing, Spigelman, Aliya F., Baronio, Roberta, Bautista, Austin, Thomsen, Soren K., Lyon, James, Nawaz, Sameena, Smith, Nancy, Wesolowska-Andersen, Agata, Fox, Jocelyn E. Manning, Sun, Han, Kim, Seung K., Ebner, Daniel, MacDonald, Patrick E., Gloyn, Anna L.

“…Identification of the genes and processes mediating genetic association signals for complex diseases represents a major challenge. As many of the genetic…”
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318-OR: Ciliary GPCRs Regulate Glucose-Stimulated Insulin Secretion by WU, CHIEN-TING, HILGENDORF, KEREN, HANG, YAN, BEVACQUA, ROMINA J., JOHNSON, CARL T., CHANG, CHARLES A., PARK, SANGBIN, TELLEZ, KRISSIE, KIM, SEUNG, JACKSON, PETER K.

“…Defects in primary cilia result in syndromes collectively called “ciliopathies”, which often present with obesity and diabetes. Although glucose is the primary…”
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Bovine parthenogenotes produced by inhibition of first or second polar bodies emission by Bevacqua, Romina J, Fernandez-Martin, Rafael, Salamone, Daniel F

“…Parthenogenetic embryos are an ethically acceptable alternative for the derivation of human embryonic stem cells. In this work, we propose a new strategy to…”
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CRISPR-on for activation of endogenous SMARCA4 and TFAP2C expression in bovine embryos by Savy, Virginia, Alberio, Virgilia, Canel, Natalia G, Ratner, Laura D, Gismondi, Maria I, Ferraris, Sergio F, Fernandez-Martín, Rafael, Knott, Jason G, Bevacqua, Romina J, Salamone, Daniel F

“…CRISPR-mediated transcriptional activation, also known as CRISPR-on, has proven efficient for activation of individual or multiple endogenous gene expression…”
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HNF1α maintains pancreatic α and β cell functions in primary human islets by Qian, Mollie F, Bevacqua, Romina J, Coykendall, Vy Mn, Liu, Xiong, Zhao, Weichen, Chang, Charles A, Gu, Xueying, Dai, Xiao-Qing, MacDonald, Patrick E, Kim, Seung K

“…HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes (HNF1A-maturity onset diabetes of the young [HNF1A-MODY]), and hypomorphic…”
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High rates of bovine blastocyst development after ICSI-mediated gene transfer assisted by chemical activation by Bevacqua, Romina J., Pereyra-Bonnet, Federico, Fernandez-Martin, Rafael, Salamone, Daniel F.

“…In order to establish conditions for intracytoplasmic sperm injection-mediated gene transfer (ICSI-MGT) in cattle, various aspects of fertilization and…”
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Establishment of cell-based transposon-mediated transgenesis in cattle by Alessio, Ana P., Fili, Alejandro E., Garrels, Wiebke, Forcato, Diego O., Olmos Nicotra, María F., Liaudat, Ana C., Bevacqua, Romina J., Savy, Virginia, Hiriart, María I., Talluri, Thirumala R., Owens, Jesse B., Ivics, Zoltán, Salamone, Daniel F., Moisyadi, Stefan, Kues, Wilfried A., Bosch, Pablo

“…Transposon-mediated transgenesis is a well-established tool for genome modification in small animal models. However, translation of this active transgenic…”
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Crotamine, a cell-penetrating peptide, is able to translocate parthenogenetic and in vitro fertilized bovine embryos but does not improve exogenous DNA expression by Campelo, Iana S., Canel, Natalia G., Bevacqua, Romina J., Melo, Luciana M., Rádis-Baptista, Gandhi, Freitas, Vicente J. F., Salamone, Daniel F.

“…Purpose Crotamine is capable of penetrating cells and embryos and transfecting cells with exogenous DNA. However, no studies are available regarding its uptake…”
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Molecular and genetic regulation of pig pancreatic islet cell development by Kim, Seokho, Whitener, Robert L, Peiris, Heshan, Gu, Xueying, Chang, Charles A, Lam, Jonathan Y, Camunas-Soler, Joan, Park, Insung, Bevacqua, Romina J, Tellez, Krissie, Quake, Stephen R, Lakey, Jonathan R T, Bottino, Rita, Ross, Pablo J, Kim, Seung K

“…Reliance on rodents for understanding pancreatic genetics, development and islet function could limit progress in developing interventions for human diseases…”
Get full text