Search Results - "Beuzard, Y."

Mouse models of sickle cell disease by Beuzard, Y.

“…In the absence of a natural animal model for sickle cell disease, transgenic mouse models have been generated to better understand the complex pathophysiology…”
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Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy by Pawliuk, Robert, Westerman, Karen A., Fabry, Mary E., Payen, Emmanuel, Tighe, Robert, Bouhassira, Eric E., Acharya, Seetharama A., Ellis, James, London, Irving M., Eaves, Connie J., Humphries, R. Keith, Beuzard, Yves, Nagel, Ronald L., Leboulch, Philippe

“…Sickle cell disease (SCD) is caused by a single point mutation in the human βAglobin gene that results in the formation of an abnormal hemoglobin [HbS (α2βS…”
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Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy by Bertheau, P, Plassa, F, Espié, M, Turpin, E, de Roquancourt, A, Marty, M, Lerebours, F, Beuzard, Y, Janin, A, de Thé, H

“…TP53 activation by genotoxic drugs can induce apoptosis or cell-cycle arrest. Thus, whether the gene is mutated or wild type could affect the response of a…”
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Death switch for gene therapy: application to erythropoietin transgene expression by Souza, D S, Spencer, D M, Salles, T S I, Salomão, M A, Payen, E, Beuzard, Y, Carvalho, H F, Costa, F F, Saad, S T Olalla

“…The effectiveness of the caspase-9-based artificial "death switch" as a safety measure for gene therapy based on the erythropoietin (Epo) hormone was tested in…”
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Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts by REGULIER, E, SCHNEIDER, B. L, DEGLON, N, BEUZARD, Y, AEBISCHER, P

“…The transplantation of polymer encapsulated myoblasts genetically engineered to secrete erythropoietin (Epo) may obviate the need for repeated parenteral…”
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Towards gene therapy of hemoglobinopathies by Beuzard, Y

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Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia by Thompson, Alexis A, Walters, Mark C, Kwiatkowski, Janet, Rasko, John E.J, Ribeil, Jean-Antoine, Hongeng, Suradej, Magrin, Elisa, Schiller, Gary J, Payen, Emmanuel, Semeraro, Michaela, Moshous, Despina, Lefrere, Francois, Puy, Hervé, Bourget, Philippe, Magnani, Alessandra, Caccavelli, Laure, Diana, Jean-Sébastien, Suarez, Felipe, Monpoux, Fabrice, Brousse, Valentine, Poirot, Catherine, Brouzes, Chantal, Meritet, Jean-François, Pondarré, Corinne, Beuzard, Yves, Chrétien, Stany, Lefebvre, Thibaud, Teachey, David T, Anurathapan, Usanarat, Ho, P. Joy, von Kalle, Christof, Kletzel, Morris, Vichinsky, Elliott, Soni, Sandeep, Veres, Gabor, Negre, Olivier, Ross, Robert W, Davidson, David, Petrusich, Alexandria, Sandler, Laura, Asmal, Mohammed, Hermine, Olivier, De Montalembert, Mariane, Hacein-Bey-Abina, Salima, Blanche, Stéphane, Leboulch, Philippe, Cavazzana, Marina

“…Gene therapy with CD34+ cells transduced with a lentivirus vector carrying a β-globin gene was performed in 22 patients. At a median of 26 months, all the…”
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Effect of excess α-hemoglobin chains on cellular and membrane oxidation in model β-thalassemic erythrocytes by SCOTT, M. D, VAN DEN BERG, J. J. M, REPKA, T, ROUYER-FESSARD, P, HEBBEL, R. P, BEUZARD, Y, LUBIN, B. H

“…While red cells from individuals with beta thalassemias are characterized by evidence of elevated in vivo oxidation, it has not been possible to directly…”
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Sustained Delivery of Erythropoietin in Mice by Genetically Modified Skin Fibroblasts by Naffakh, N., Henri, A., Villeval, J. L., Rouyer-Fessard, P., Moullier, P., Blumenfeld, N., Danos, O., Vainchenker, W., Heard, J. M., Beuzard, Y.

“…We have examined whether the secretion of erythropoietin (Epo) from genetically modified cells could represent an alternative to repeated injections of the…”
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Improvement of mouse β-thalassemia upon erythropoietin delivery by encapsulated myoblasts by DALLE, B, PAYEN, E, REGULIER, E, DEGLON, N, ROUYER-FESSARD, P, BEUZARD, Y, AEBISCHER, P

“…The goal of the present study was to analyze if sustained delivery of elevated doses of recombinant erythropoietin (Epo), by genetically modified and…”
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Oxygen tension and a pharmacological switch in the regulation of transgene expression for gene therapy by Payen, E., Bettan, M., Henri, A., Tomkiewitcz, E., Houque, A., Kuzniak, I., Zuber, J., Scherman, D., Beuzard, Y.

“…Background The combination of physiologically and pharmacologically controlled elements may provide a means to ensure both the regulation and the safety of…”
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The effect of hemoglobin A and S on the volume- and pH-dependence of K-Cl cotransport in human erythrocyte ghosts by Vitoux, D, Beuzard, Y, Brugnara, C

“…K-Cl cotransport is abnormally active in erythrocytes containing positively charged hemoglobins such as Hb S (SS: beta6 Glu --> Val) or Hb C (CC: beta6 Glu -->…”
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Early diagnosis of renal function recovery by cystatin C in renal allograft recipients by Thervet, E, Le Bricon, T, Hugot, V, Benlakehal, M, Bedrossian, J, Beuzard, Y, Legendre, C, Erlich, D

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Sulfhydryl oxidation and activation of red cell K(+)-Cl- cotransport in the transgenic SAD mouse by De Franceschi, L, Beuzard, Y, Brugnara, C

“…The SAD mouse is characterized by the expression of human SAD hemoglobin (Hb), a super S Hb with a higher tendency to polymerize than HbS due to the presence…”
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Red Blood Cell Indices, Cation Content, and Membrane Cation Transports by de Franceschi, L., Beuzard, Y.

“…In sickle cell disease, in the homozygous state, the increased heterogeneity of erythrocytes results mainly from membrane defects secondary to Hb S…”
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Improvement of Mouse β-Thalassemia by Recombinant Human Erythropoietin by Leroy-Viard, K., Rouyer-Fessard, P., Beuzard, Y.

“…Homozygous β thalassemic mice received 50 U (1,660 U/kg) of recombinant human erythropoietin (rhEpo) 5 days a week for 2 weeks. Hemoglobin increased from 9.2 ±…”
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Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization by Garel, M C, Domenget, C, Caburi-Martin, J, Prehu, C, Galacteros, F, Beuzard, Y

“…Thiol reagents react with cysteine beta 93 of hemoglobin and as a result increase the oxygen affinity of hemoglobin. In the present studies we have used a…”
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Isoelectric Focusing of Human Hemoglobin: Its Application to Screening, to the Characterization of 70 Variants, and to the Study of Modified Fractions of Normal Hemoglobins by Basset, P., Beuzard, Y., Garel, M.C., Rosa, J.

“…Isoelectric focusing on slabs of acryIamide gel was adapted for the screening of abnormal hemoglobins, the characterization of 70 human variants, and the study…”
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Organoids direct systemic expression of erythropoietin in mice by Descamps, V, Blumenfeld, N, Perricaudet, M, Beuzard, Y, Kremer, E J

“…Organoids are adenoviral vector transduced cells embedded ex vivo in a collagen-polytetrafluoroethylene lattice that is saturated with angiogenic factors…”
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A study of membrane protein defects and α hemoglobin chains of red blood cells in human β thalassemia by Rouyer-Fessard, P, Garel, M C, Domenget, C, Guetarni, D, Bachir, D, Colonna, P, Beuzard, Y

“…The soluble pool of α hemoglobin chains present in blood or bone marrow cells was measured with a new affinity method using a specific probe, β A hemoglobin…”
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