Search Results - "Beuvery, E.C"

practical approach for exploration and modeling of the design space of a bacterial vaccine cultivation process by Streefland, M, Van Herpen, P.F.G, Van de Waterbeemd, B, Van der Pol, L.A, Beuvery, E.C, Tramper, J, Martens, D.E, Toft, M

“…A licensed pharmaceutical process is required to be executed within the validated ranges throughout the lifetime of product manufacturing. Changes to the…”
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Determination of amino acids using o-phthalaldehyde-2-mercaptoethanol derivatization effect of reaction conditions by Dorresteijn, R.C., Berwald, L.G., Zomer, G., de Gooijer, C.D., Wieten, G., Beuvery, E.C.

“…This paper presents a systematic approach to determine the optimal reaction conditions, with respect to accuracy and sensitivity, of the quantitative…”
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Modeling Neisseria meningitidis metabolism: from genome to metabolic fluxes by Baart, Gino J E, Zomer, Bert, de Haan, Alex, van der Pol, Leo A, Beuvery, E Coen, Tramper, Johannes, Martens, Dirk E

“…Neisseria meningitidis is a human pathogen that can infect diverse sites within the human host. The major diseases caused by N. meningitidis are responsible…”
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Gene-expression-based quality scores indicate optimal harvest point in Bordetella pertussis cultivation for vaccine production by van de Waterbeemd, Bas, Streefland, Mathieu, Pennings, Jeroen, van der Pol, Leo, Beuvery, Coen, Tramper, Johannes, Martens, Dirk

“…The evolution of vaccine product quality during batch cultivation of Bordetella pertussis, the causative agent of whooping cough, was investigated with the…”
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Modeling Neisseria meningitidis B metabolism at different specific growth rates by Baart, Gino J.E, Willemsen, Marieke, Khatami, Elnaz, de Haan, Alex, Zomer, Bert, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Neisseria meningitidis is a human pathogen that can infect diverse sites within the human host. The major diseases caused by N. meningitidis are responsible…”
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Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers by MARTENS, D. E, NOLLEN, E. A. A, HARDEVELD, M, VAN DER VELDEN-DE GROOT, C. A. M, DE GOOIJER, C. D, BEUVERY, E. C, TRAMPER, J

“…The death rate of Vero cells grown on Cytodex-3 microcarrierswas studied as a function of the gas flow rate in a smallair-lift loop reactor. The death rate may…”
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Improving the cellular pertussis vaccine: Increased potency and consistency by Thalen, Marcel, van der Ark, Arno, van den IJssel, Jan, van Straaten, Ineke, Jansen, Dennis, Beuvery, Coen, Martens, Dirk, Tramper, Johannes

“…Summary Although Europe, Canada and the US have switched from cellular to acellular pertussis vaccines, most developing countries will continue to use the more…”
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PAT for vaccines: The first stage of PAT implementation for development of a well-defined whole-cell vaccine against whooping cough disease by Streefland, Mathieu, van de Waterbeemd, Bas, Happé, Hester, van der Pol, Leo A, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Abstract Since variation in process time and process output is commonly accepted to be inevitable for biological processes, application of Process Analytical…”
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Expression of phosphofructokinase in Neisseria meningitidis by Baart, Gino J. E, Langenhof, Marc, van de Waterbeemd, Bas, Hamstra, Hendrik-Jan, Zomer, Bert, van der Pol, Leo A, Beuvery, E. C, Tramper, Johannes, Martens, Dirk E

“…1 Netherlands Vaccine Institute (NVI), Unit Research and Development, PO Box 457, 3720 AL Bilthoven, The Netherlands 2 Wageningen University, Food and…”
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Scale-up for bulk production of vaccine against meningococcal disease by Baart, Gino J.E, de Jong, Govert, Philippi, Marvin, Riet, Klaas van’t, van der Pol, Leo A, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Abstract At the Netherlands Vaccine Institute (NVI) a vaccine against Neisseria meningitidis serogroup B organisms based on different porA subtypes contained…”
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Evaluation of a critical process parameter: Oxygen limitation during cultivation has a fully reversible effect on gene expression of Bordetella pertussis by Streefland, Mathieu, van de Waterbeemd, Bas, Kint, Joeri, van der Pol, Leo A, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Modern (bio)pharmaceutical process development requires thorough investigation of all process parameters that are critical to product quality. The impact of a…”
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Effect of relevant culture parameters on Pertussis Toxin expression by Bordetella pertussis by Thalen, Marcel, Venema, Marian, van den IJssel, Jan, Berwald, Luc, Beuvery, Coen, Martens, Dirk, Tramper, Johannes

“…Whooping cough vaccines are produced using different ranges of cultivation conditions and medium compositions, which are known to influence growth rate,…”
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Fed-batch cultivation of Bordetella pertussis: Metabolism and Pertussis Toxin production by Thalen, Marcel, Venema, Marian, Dekker, Anita, Berwald, Luc, van den IJssel, Jan, Zomer, Bert, Beuvery, Coen, Martens, Dirk, Tramper, Johannes

“…The production of acellular pertussis in comparison with whole cell pertussis vaccines demands 5–25 times the amount of Bordetella pertussis' virulence…”
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Dual-substrate utilization by Bordetella pertussis by NEELEMAN, R, JOERINK, M, BEUVERY, C, VAN BOXTEL, T

“…To improve the cultivation of Bordetella pertussis and take advantage of the newest techniques in monitoring and control, a quantitative description of…”
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Manufacturing Vaccines: An Illustration of Using PAT Tools for Controlling the Cultivation of Bordetella pertussis by van Sprang, Eric N. M., Streefland, Mathieu, Ramaker, Henk-Jan, van der Pol, Leo A., Beuvery, E. Coen, Smilde, Age. K.

“…An illustration of the operational consistency of the upstream part of a biopharmaceutical process is given. For this purpose four batch cultivations of…”
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Determination of amino acids using 0-phthalaldehyde-2-mercaptoethanol derivation. Effect of reaction conditions by Dorresteijn, R.C, Berwald, L.G, Zomer, G, Gooijer, C.D., de, Wieten, G, Beuvery, E.C

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Comparison of four bifunctional reagents for coupling peptides to proteins and the effect of the three moieties on the immunogenicity of the conjugates by Peeters, J M, Hazendonk, T G, Beuvery, E C, Tesser, G I

“…Peptide-carrier conjugates are widely used to raise antipeptide antibodies. In a model system using angiotensin and tetanus toxoid as the peptide and the…”
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On-line estimation of the biomass activity during animal-cell cultivations by Dorresteijn, R.C, Harbrink Numan, K, Gooijer, C.D., de, Tramper, J, Beuvery, E.C

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On-line estimation of the biomass activity during animal-cell cultivations by Dorresteijn, R.C, Harbrink Numan, K, Gooijer, C.D. de, Tramper, J, Beuvery, E.C

“…A software sensor was developed to determine the volumetric biomass activity of animal cell cultivations on-line. It was based on the on-line estimation of the…”
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A New WHO International Reference Reagent for Use in Potency Assays of Inactivated Poliomyelitis Vaccine by Wood, D.J., Heath, A.B., Kersten, G.F.A., Hazendonk, T., Lantinga, M., Beuvery, E.C.

“…Assays of the potency of inactivated poliovirus vaccine require the use of an appropriate reference reagent. Preparation 91/574 was shown by international…”
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