Search Results - "Beuvery, E Coen"

Scale-up for bulk production of vaccine against meningococcal disease by Baart, Gino J.E, de Jong, Govert, Philippi, Marvin, Riet, Klaas van’t, van der Pol, Leo A, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Abstract At the Netherlands Vaccine Institute (NVI) a vaccine against Neisseria meningitidis serogroup B organisms based on different porA subtypes contained…”
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Evaluation of a critical process parameter: Oxygen limitation during cultivation has a fully reversible effect on gene expression of Bordetella pertussis by Streefland, Mathieu, van de Waterbeemd, Bas, Kint, Joeri, van der Pol, Leo A, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Modern (bio)pharmaceutical process development requires thorough investigation of all process parameters that are critical to product quality. The impact of a…”
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Modeling Neisseria meningitidis metabolism: from genome to metabolic fluxes by Baart, Gino J E, Zomer, Bert, de Haan, Alex, van der Pol, Leo A, Beuvery, E Coen, Tramper, Johannes, Martens, Dirk E

“…Neisseria meningitidis is a human pathogen that can infect diverse sites within the human host. The major diseases caused by N. meningitidis are responsible…”
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Modeling Neisseria meningitidis B metabolism at different specific growth rates by Baart, Gino J.E, Willemsen, Marieke, Khatami, Elnaz, de Haan, Alex, Zomer, Bert, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Neisseria meningitidis is a human pathogen that can infect diverse sites within the human host. The major diseases caused by N. meningitidis are responsible…”
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PAT for vaccines: The first stage of PAT implementation for development of a well-defined whole-cell vaccine against whooping cough disease by Streefland, Mathieu, van de Waterbeemd, Bas, Happé, Hester, van der Pol, Leo A, Beuvery, E. Coen, Tramper, Johannes, Martens, Dirk E

“…Abstract Since variation in process time and process output is commonly accepted to be inevitable for biological processes, application of Process Analytical…”
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Manufacturing Vaccines: An Illustration of Using PAT Tools for Controlling the Cultivation of Bordetella pertussis by van Sprang, Eric N. M., Streefland, Mathieu, Ramaker, Henk-Jan, van der Pol, Leo A., Beuvery, E. Coen, Smilde, Age. K.

“…An illustration of the operational consistency of the upstream part of a biopharmaceutical process is given. For this purpose four batch cultivations of…”
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Preparation and application of a fluorescein-labeled peptide for determining the affinity constant of a monoclonal antibody-hapten complex by fluorescence polarization by Jiskoot, W, Hoogerhout, P, Beuvery, E C, Herron, J N, Crommelin, D J

“…A simple and rapid method for determining the affinity constant of a monoclonal antibody-peptide complex under equilibrium conditions is presented. A peptide…”
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Preparation of clinical grade monoclonal antibodies from serum-containing cell culture supernatants by Jiskoot, W, Van Hertrooij, J J, Hoven, A M, Klein Gebbinck, J W, Van der Velden-de Groot, T, Crommelin, D J, Beuvery, E C

“…Three mouse monoclonal antibodies (Mab), RIV6, MN12, and WT31, were purified from cell culture supernatants containing foetal bovine serum (FBS) by two-step…”
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Analysis of glycoforms present in two mouse IgG2a monoclonal antibody preparations by Coco-Martin, J M, Brunink, F, van der Velden-de Groot, T A, Beuvery, E C

“…Lectins have been used for the determination of the oligosaccharide structures expressed by two monoclonal IgG antibodies, MN12 and RIV6. Dot blot experiments…”
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Preparation, Antigenicity, and Immunogenicity of Synthetic Ribosylribitol Phosphate Oligomer-Protein Conjugates and Their Potential Use for Vaccination against Haemophilus influenzae Type b Disease by Evenberg, Dolf, Hoogerhout, Peter, van Boeckel, Constant A. A., Rijkers, Ger T., Beuvery, E. Coen, van Boom, Jacques H., Poolman, Jan T.

“…Synthetically prepared ribosylribitol phosphate dimer and trimer analogous to fragments of the capsular polysaccharide of Haemophilus influenzae type b,…”
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Two-step purification of a murine monoclonal antibody intended for therapeutic application in man. Optimisation of purification conditions and scaling up by Jiskoot, W, Van Hertrooij, J J, Klein Gebbinck, J W, Van der Velden-de Groot, T, Crommelin, D J, Beuvery, E C

“…The murine hybridoma cell line WT31, which produces a monoclonal antibody (Mab) of the IgG1 isotype with specificity for the human T cell receptor, was grown…”
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Viability measurements of hybridoma cells in suspension cultures by COCO-MARTIN, J. M, OBERINK, J. W, VAN DER VELDEN-DE GROOT, T. A. M, COEN BEUVERY, E

“…Several methods were applied to determine the viability of hybridoma cells in suspension. These methods include dye inclusion and exclusion assays such as the…”
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Purification and stabilisation of a poorly soluble mouse IgG3 monoclonal antibody by Jiskoot, W, Hoven, A M, De Koning, A A, Leerling, M F, Reubsaet, C H, Crommelin, D J, Beuvery, E C

“…The anti-T cell monoclonal antibody (Mab) RIV9 (mouse IgG3, kappa) has been developed for clinical use in the treatment of allograft rejection. In order to…”
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The potential of flow cytometric analysis for the characterization of hybridoma cells in suspension cultures by COCO-MARTIN, J. M, OBERINK, J. W, VAN DER VELDEN-DE GROOT, T. A. M, COEN BEUVERY, E

“…Flow cytometric (FC) analysis was applied to determine changes at cellular level during the cultivation of hybridoma cell line MN12 in a suspension batch…”
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Immunological evaluation of meningococcal group C polysaccharide-tetanus toxoid conjugate in mice by COEN BEUVERY, E, VAN DELFT, R. W, MIEDEMA, F, KANHAI, V, NAGEL, J

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Immunoglobulin M and G antibody responses and persistence of these antibodies in adults after vaccination with a combined meningococcal group A and group C polysaccharide vaccine by Beuvery, E C, Leussink, A B, Van Delft, R W, Tiesjema, R H, Nagel, J

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Single shot with tetanus toxoid in biodegradable microspheres protects mice despite acid-induced denaturation of the antigen by Kersten, Gideon F.A., Donders, Dian, Akkermans, Arnoud, Beuvery, E.Coen

“…Tetanus toxoid encapsulated in microspheres consisting of biodegradable polyesters, prepared by four different manufacturers were evaluated with respect to…”
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Randomised, controlled trial with the trypsin-modified inactivated poliovirus vaccine: assessment of intestinal immunity with live challenge virus by Piirainen, Liisa, Stenvik, Mirja, Roivainen, Merja, Eskola, Juhani, Beuvery, E.Coen, Hovi, Tapani

“…The enhanced potency inactivated poliovirus vaccine (E-IPV) was modified to contain trypsin-treated type 3 poliovirus (PV3), strain Saukett, as the type 3…”
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On the structure of immune-stimulating saponin-lipid complexes (iscoms) by Kersten, G F, Spiekstra, A, Beuvery, E C, Crommelin, D J

“…Immune-stimulating complexes (iscoms) are stable complexes of cholesterol, phospholipid and Quil A, a triterpene saponin mixture in the size range from 40 to…”
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Analytical approaches to the study of monoclonal antibody stability by JISKOOT, W, BEUVERY, E. C, DE KONING, A. A. M, HERRON, J. N, CROMMELIN, D. J. A

“…The stability of two purified monoclonal antibodies, MN12 and WT31, was investigated. The monoclonal antibodies were incubated for 32 days at different pH…”
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