Search Results - "Beurskens, Charlotte J"

Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial by Straat, Marleen, Müller, Marcella C A, Meijers, Joost C M, Arbous, Mendi S, Spoelstra-de Man, Angelique M E, Beurskens, Charlotte J P, Vroom, Margreeth B, Juffermans, Nicole P

“…Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have…”
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Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover by Beurskens, Charlotte J P, Aslami, Hamid, Kuipers, Maria T, Horn, Janneke, Vroom, Margreeth B, van Kuilenburg, André B P, Roelofs, Joris J. T H, Schultz, Marcus J, Juffermans, Nicole P

“…OBJECTIVE:To determine the effect of induced hypothermia on bacterial growth, lung injury, and mitochondrial function in a rat model of pneumococcal…”
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Heliox allows for lower minute volume ventilation in an animal model of ventilator-induced lung injury by Beurskens, Charlotte J, Aslami, Hamid, de Beer, Friso M, Vroom, Margreeth B, Preckel, Benedikt, Horn, Janneke, Juffermans, Nicole P

“…Helium is a noble gas with a low density, allowing for lower driving pressures and increased carbon dioxide (CO2) diffusion. Since application of protective…”
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Hydrogen sulfide donor NaHS reduces organ injury in a rat model of pneumococcal pneumosepsis, associated with improved bio-energetic status by Aslami, Hamid, Pulskens, Wilco P, Kuipers, Maria T, Bos, Aafkeline P, van Kuilenburg, André B P, Wanders, Ronald J A, Roelofsen, Jeroen, Roelofs, Joris J T H, Kerindongo, Raphaela P, Beurskens, Charlotte J P, Schultz, Marcus J, Kulik, Wim, Weber, Nina C, Juffermans, Nicole P

“…Sepsis is characterized by a generalized inflammatory response and organ failure, associated with mitochondrial dysfunction. Hydrogen sulfide donor NaHS has…”
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Proven Fatal Invasive Aspergillosis in a Patient with COVID-19 and Staphylococcus aureus Pneumonia by van Someren Gréve, Frank, du Long, Romy, Talwar, Raju, Beurskens, Charlotte J P, Voerman, Huibertus J, van Dijk, Karin

“…There is increasing attention for opportunistic pathogens such as complicating SARS-CoV-2 infections in the critically ill. For invasive fungal disease,…”
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Nebulized C1-Esterase Inhibitor does not Reduce Pulmonary Complement Activation in Rats with Severe Streptococcus Pneumoniae Pneumonia by de Beer, Friso, Lagrand, Wim, Glas, Gerie J., Beurskens, Charlotte J. P., van Mierlo, Gerard, Wouters, Diana, Zeerleder, Sacha, Roelofs, Joris J. T. H., Juffermans, Nicole P., Horn, Janneke, Schultz, Marcus J.

“…Complement activation plays an important role in the pathogenesis of pneumonia. We hypothesized that inhibition of the complement system in the lungs by…”
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A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion by Aslami, Hamid, Beurskens, Charlotte J.P., Beer, Friso M. de, Kuipers, Maria T., Roelofs, Joris J.T.H., Hegeman, Maria A., Van der Sluijs, Koen F., Schultz, Marcus J., Juffermans, Nicole P.

“…► A short course of H2S infusion reduces lung and kidney injury in endotoxemia. ► Prolonged H2S infusion does not enhance organ protective effects. ► H2S…”
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Heliox Improves Carbon Dioxide Removal during Lung Protective Mechanical Ventilation by Juffermans, Nicole P., Preckel, Benedikt, Vroom, Margreeth B., van den Bergh, Walter M., Lagrand, Wim K., Brevoord, Daniel, Beurskens, Charlotte J., Horn, Janneke

“…Introduction. Helium is a noble gas with low density and increased carbon dioxide (CO2) diffusion capacity. This allows lower driving pressures in mechanical…”
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Cardiac arrest patients have an impaired immune response, which is not influenced by induced hypothermia by Beurskens, Charlotte J, Horn, Janneke, de Boer, Anita M Tuip, Schultz, Marcus J, van Leeuwen, Ester Mm, Vroom, Margreeth B, Juffermans, Nicole P

“…Induced hypothermia is increasingly applied as a therapeutic intervention in ICUs. One of the underlying mechanisms of the beneficial effects of hypothermia is…”
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Helium ventilation for treatment of post-cardiac arrest syndrome: A safety and feasibility study by Brevoord, Daniel, Beurskens​, Charlotte J.P, van den Bergh, Walter M, Lagrand, Wim K, Juffermans, Nicole P, Binnekade, Jan M, Preckel, Benedikt, Horn, Janneke

“…Abstract Aim Besides supportive care, the only recommended treatment for comatose patients after cardiac arrest is target temperature management. Helium…”
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Changes in the inflammatory response following cardiac arrest: A matter of ischemia/reperfusion or induced hypothermia? by Beurskens, Charlotte J P, Juffermans, Nicole P

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Induced hypothermia is associated with reduced circulating subunits of mitochondrial DNA in cardiac arrest patients by Aslami, Hamid, Beurskens, Charlotte J P, Tuip, Anita M, Horn, Janneke, Juffermans, Nicole P

“…Induced hypothermia may protect from ischemia reperfusion injury. The mechanism of protection is not fully understood and may include an effect on…”
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The potential of heliox as a therapy for acute respiratory distress syndrome in adults and children: a descriptive review by Beurskens, Charlotte J P, Wösten-van Asperen, Roelie M, Preckel, Benedikt, Juffermans, Nicole P

“…In neonatal respiratory distress syndrome (RDS) and acute RDS (ARDS) mechanical ventilation is often necessary to manage hypoxia, whilst protecting the lungs…”
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Mild hypothermia reduces ventilator–induced lung injury, irrespective of reducing respiratory rate by Aslami, Hamid, Kuipers, Maria T, Beurskens, Charlotte J.P, Roelofs, Joris J.T.H, Schultz, Marcus J, Juffermans, Nicole P

“…In the era of lung-protective mechanical ventilation using limited tidal volumes, higher respiratory rates are applied to maintain adequate minute volume…”
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Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome by Beurskens, Charlotte J, Aslami, Hamid, de Beer, Friso M, Roelofs, Joris JTH, Vroom, Margreeth B, Juffermans, Nicole P

“…Background Heliox has a lower density and higher diffusion capacity compared to oxygen-in-air. We hypothesized that heliox ventilation allows for a reduction…”
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Proven Fatal Invasive Aspergillosis in a Patient with COVID-19 and Staphylococcus aureus Pneumonia by van Someren Gréve, Frank, du Long, Romy, Talwar, Raju, Beurskens, Charlotte J P, Voerman, Huibertus J, van Dijk, Karin

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Hydrogen Sulfide Donor NaHS Reduces Organ Injury in a Rat Model of Pneumococcal Pneumosepsis, Associated with Improved Bio-Energetic Status. e63497 by Aslami, Hamid, Pulskens, Wilco P, Kuipers, Maria T, Bos, Aafkeline P, Kuilenburg, B Pvan, Wanders, Ronald JA, Roelofsen, Jeroen, Roelofs, J TH, Kerindongo, Raphaela P, Beurskens, Charlotte JP

“…Sepsis is characterized by a generalized inflammatory response and organ failure, associated with mitochondrial dysfunction. Hydrogen sulfide donor NaHS has…”
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