Search Results - "Beurel, Eléonore"

The Bidirectional Relationship of Depression and Inflammation: Double Trouble by Beurel, Eléonore, Toups, Marisa, Nemeroff, Charles B.

“…Depression represents the number one cause of disability worldwide and is often fatal. Inflammatory processes have been implicated in the pathophysiology of…”
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Th17 cells in depression by Beurel, Eléonore, Lowell, Jeffrey A.

“…•Th17 cells are increased in the blood of depressed patients.•Th17 cells promote depressive-like behaviors in mice.•Th17 cells are pathogenic in most CNS…”
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Stress in the microbiome-immune crosstalk by Beurel, Eléonore

“…The gut microbiota exerts a mutualistic interaction with the host in a fragile ecosystem and the host intestinal, neural, and immune cells. Perturbations of…”
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Blood brain barrier and inflammation in depression by Medina-Rodriguez, Eva M., Beurel, Eléonore

“…The blood brain barrier (BBB) is a vital structure to protect the brain, tightly filtering the passage of nutrients and molecules from the blood to the brain…”
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The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways by Beurel, Eléonore, Jope, Richard S

“…Few things can be considered to be more important to a cell than its threshold for apoptotic cell death, which can be modulated up or down, but rarely in both…”
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Inflammatory T Helper 17 Cells Promote Depression-like Behavior in Mice by Beurel, Eléonore, Harrington, Laurie E, Jope, Richard S

“…Background Recognition of substantial immune-neural interactions is revising dogmas about their insular actions and revealing that immune-neural interactions…”
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HDAC6 regulates LPS-tolerance in astrocytes by Beurel, Eléonore

“…Inflammatory tolerance is a crucial mechanism that limits inflammatory responses in order to avoid prolonged inflammation that may damage the host. Evidence…”
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Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3) by Beurel, Eléonore, Michalek, Suzanne M, Jope, Richard S

“…In just a few years, the view of glycogen synthase kinase-3 (GSK3) has been transformed from an obscure enzyme seldom encountered in the immune literature to…”
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Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells by Beurel, Eléonore, Medina-Rodriguez, Eva M, Jope, Richard S

“…There is a vital need to understand mechanisms contributing to susceptibility to depression to improve treatments for the 11% of Americans who currently suffer…”
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Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice by Medina-Rodriguez, Eva M, Madorma, Derik, O'Connor, Gregory, Mason, Brittany L, Han, Dongmei, Deo, Sapna K, Oppenheimer, Mark, Nemeroff, Charles B, Trivedi, Madhukar H, Daunert, Sylvia, Beurel, Eléonore

“…Microbiota dysbiosis has been linked to major depressive disorder, but the mechanisms whereby the microbiota modulates mood remain poorly understood. The…”
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Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain by Beurel, Eléonore, Jope, Richard S

“…Septic shock is a prevalent condition that, when not lethal, often causes disturbances in cognition, mood, and behavior, particularly due to central actions of…”
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Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics by Jope, Richard S, Yuskaitis, Christopher J, Beurel, Eléonore

“…Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase…”
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Stress promotes the infiltration of peripheral immune cells to the brain by Medina-Rodriguez, Eva M., Han, Dongmei, Lowell, Jeffrey, Beurel, Eléonore

“…•Immune cell presence in the brain after learned helplessness is well-orchestrated.•Microbiota and sex regulate the presence of immune cells in the…”
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RNA tailing machinery drives amyloidogenic phase transition by Bokros, Michael, Balukoff, Nathan C, Grunfeld, Alex, Sebastiao, Mathew, Beurel, Eléonore, Bourgault, Steve, Lee, Stephen

“…The RNA tailing machinery adds nucleotides to the 3'-end of RNA molecules that are implicated in various biochemical functions, including protein synthesis and…”
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Early Life Adversity, Microbiome, and Inflammatory Responses by Beurel, Eléonore, Nemeroff, Charles B

“…Early life adversity has a profound impact on physical and mental health. Because the central nervous and immune systems are not fully mature at birth and…”
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Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3 by Beurel, Eléonore, Jope, Richard S.

“…Excessive neuroinflammation contributes to many neurological disorders and is poorly controlled therapeutically. The signal transducer and activator of…”
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Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments by King, Margaret K, Pardo, Marta, Cheng, Yuyan, Downey, Kimberlee, Jope, Richard S, Beurel, Eléonore

“…Impairment of cognitive processes is a devastating outcome of many diseases, injuries, and drugs affecting the central nervous system (CNS). Most often, very…”
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Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling by Beurel, Eléonore, Grieco, Steven F., Amadei, Celeste, Downey, Kimberlee, Jope, Richard S

“…Objectives Sub‐anesthetic doses of ketamine have been found to provide rapid antidepressant actions, indicating that the cellular signaling systems targeted by…”
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Stress, inflammation, microbiome and depression by Medina-Rodriguez, Eva M., Cruz, Alyssa A., De Abreu, Julia Cavati, Beurel, Eléonore

“…Psychiatric disorders are mental illnesses involving changes in mood, cognition and behavior. Their prevalence has rapidly increased in the last decades. One…”
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I-BET151 selectively regulates IL-6 production by Barrett, Elyse, Brothers, Shaun, Wahlestedt, Claes, Beurel, Eléonore

“…Orchestration of the inflammatory response is crucial for clearing pathogens. Although the production of multiple inflammatory cytokines has been thought to be…”
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