Search Results - "Beumer, Tim L"

Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-Tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis by van Amerongen, Guido, MSc, Kanhai, Kawita, MD, Baakman, Anne Catrien, MD, Heuberger, Jules, MSc, Klaassen, Erica, MSc, Beumer, Tim L., PhD, Strijers, Rob L.M., MD, PhD, Killestein, Joep, MD, PhD, van Gerven, Joop, MD, Cohen, Adam, MD, Groeneveld, Geert Jan, MD, PhD

“…Abstract Purpose The aim of the present study was to evaluate the efficacy of an oral formulation of Δ9-tetrahydrocannabinol (ECP002A) in patients with…”
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Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics by Heuberger, Jules A. A. C., Guan, Zheng, Oyetayo, Olubukayo-Opeyemi, Klumpers, Linda, Morrison, Paul D., Beumer, Tim L., van Gerven, Joop M. A., Cohen, Adam F., Freijer, Jan

“…Δ 9 -Tetrahydrocannobinol (THC), the main psychoactive compound of Cannabis, is known to have a long terminal half-life. However, this characteristic is often…”
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The role of the tumor suppressor p53 in spermatogenesis by Beumer, T L, Roepers-Gajadien, H L, Gademan, I S, van Buul, P P, Gil-Gomez, G, Rutgers, D H, de Rooij, D G

“…The p53 protein appeared to be involved in both spermatogonial cell proliferation and radiation response. During normal spermatogenesis in the mouse,…”
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Novel Δ(9) -tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects by Klumpers, Linda E, Beumer, Tim L, van Hasselt, Johan G C, Lipplaa, Astrid, Karger, Lennard B, Kleinloog, H Daniël, Freijer, Jan I, de Kam, Marieke L, van Gerven, Joop M A

“…• Cannabis based medicines are registered as a treatment for various indications, such as pain and spasms in multiple sclerosis (MS) patients, and anorexia and…”
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Novel Δ9‐tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects by Klumpers, Linda E., Beumer, Tim L., van Hasselt, Johan G. C., Lipplaa, Astrid, Karger, Lennard B., Kleinloog, H. Daniël, Freijer, Jan I., de Kam, Marieke L., van Gerven, Joop M. A.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Cannabis based medicines are registered as a treatment for various indications, such as pain and spasms in multiple…”
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Involvement of the D-Type Cyclins in Germ Cell Proliferation and Differentiation in the Mouse1 by Beumer, Tim L, Roepers-Gajadien, Hermien L, Gademan, Iris S, Kal, Henk B, de Rooij, Dirk G

“…Using immunohistochemistry, the expression of the D-type cyclin proteins was studied in the developing and adult mouse testis. Both during testicular…”
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Involvement of the D-Type Cyclins in Germ Cell Proliferation and Differentiation in the Mouse by BEUMER, Tim L, ROEPERS-GAJADIEN, Hermien L, GADEMAN, Iris S, KAL, Henk B, DE ROOIJ, Dirk G

“…Using immunohistochemistry, the expression of the D-type cyclin proteins was studied in the developing and adult mouse testis. Both during testicular…”
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The association between cytochrome P450 2D6 genotype and prescription patterns of antipsychotic and antidepressant drugs in hospitalized psychiatric patients: a retrospective follow-up study by Mulder, Hans, Wilmink, Frederik W, Beumer, Tim L, Tamminga, Wim J, Jedema, Jaap N, Egberts, Antoine C G

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Regulatory role of p27kip1 in the mouse and human testis by Beumer, T L, Kiyokawa, H, Roepers-Gajadien, H L, van den Bos, L A, Lock, T M, Gademan, I S, Rutgers, D H, Koff, A, de Rooij, D G

“…p27kip1 is a cyclin-dependent kinase inhibitor that regulates the G1/S transition of the cell cycle. Immunohistochemical analysis showed that during mouse…”
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Apoptosis regulation in the testis: Involvement of Bcl-2 family members by Beumer, Tim L., Roepers-Gajadien, Hermien L., Gademan, Iris S., Lock, Tycho M.T.W., Kal, Henk B., De Rooij, Dirk G.

“…Using immunohistochemical techniques and Western blot analysis, the possible role of Bcl‐2 family members Bax, Bcl‐2, Bcl‐xs, and Bcl‐xl in male germ cell…”
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Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis by van Amerongen, Guido, Kanhai, Kawita, Baakman, Anne Catrien, Heuberger, Jules, Klaassen, Erica, Beumer, Tim L, Strijers, Rob L M, Killestein, Joep, van Gerven, Joop, Cohen, Adam, Groeneveld, Geert Jan

“…The aim of the present study was to evaluate the efficacy of an oral formulation of Δ9-tetrahydrocannabinol (ECP002A) in patients with progressive multiple…”
Get full text

Novel Δ 9 ‐tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects by Klumpers, Linda E., Beumer, Tim L., van Hasselt, Johan G. C., Lipplaa, Astrid, Karger, Lennard B., Kleinloog, H. Daniël, Freijer, Jan I., de Kam, Marieke L., van Gerven, Joop M. A.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Cannabis based medicines are registered as a treatment for various indications, such as pain and spasms in multiple…”
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Dynamic and differential Oct-1 expression during early Xenopus embryogenesis: persistence of Oct-1 protein following down-regulation of the RNA by Veenstra, Gert Jan C., Beumer, Tim L., Peterson-Maduro, Joselin, Stegeman, Brenda I., Karg, Henk A., van der Vliet, Peter C., Destrée, Olivier H.J.

“…As a first step towards the elucidation of the role of the transcription factor Oct-1 in development, we prepared a monoclonal antibody to study the…”
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Regulatory Role of p27kip1 in the Mouse and Human Testis1 by Beumer, Tim L, Kiyokawa, Hiroaki, Roepers-Gajadien, Hermien L, van den Bos, Linda A. C, Lock, Tycho M. T. W, Gademan, Iris S, Rutgers, Derk H, Koff, Andrew, de Rooij, Dirk G

“…p27kip1 is a cyclin-dependent kinase inhibitor that regulates the G1/S transition of the cell cycle. Immunohistochemical analysis showed that during mouse…”
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Effective generation of very low density lipoprotein receptor transgenic mice by overlapping genomic DNA fragments: high testis expression and disturbed spermatogenesis by TACKEN, Paul J, VAN DER ZEE, Andre, BEUMER, Tim L, FLORIJN, Ralph J, GIJPELS, Marion J. J, HAVEKES, Louis M, FRANTS, Rune R, VAN DIJK, Ko Willems, HOFKER, Marten H

“…The generation of functional transgenes via microinjection of overlapping DNA fragments has previously been reported to be successful, but it is still not a…”
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Whole-mount immunohistochemistry on Xenopus embryos using far-red fluorescent dyes by Beumer, Tim L., Veenstra, Gert Jan C., Hage, William J., Destrée, Olivier H.J.

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