Search Results - "Beugelink, J Wouter"
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Benchmarking tomographic acquisition schemes for high-resolution structural biology
Published in Nature communications (13-02-2020)“…Cryo electron tomography with subsequent subtomogram averaging is a powerful technique to structurally analyze macromolecular complexes in their native…”
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A structural and dynamic visualization of the interaction between MAP7 and microtubules
Published in Nature communications (02-03-2024)“…Microtubules (MTs) are key components of the eukaryotic cytoskeleton and are essential for intracellular organization, organelle trafficking and mitosis. MT…”
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3
Alternative splicing controls teneurin-3 compact dimer formation for neuronal recognition
Published in Nature communications (29-04-2024)“…Neuronal network formation is facilitated by recognition between synaptic cell adhesion molecules at the cell surface. Alternative splicing of cell adhesion…”
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4
Resonance assignments of the microtubule-binding domain of the microtubule-associated protein 7 (MAP7)
Published in Biomolecular NMR assignments (01-06-2023)“…The microtubule-associated protein 7 (MAP7) is a protein involved in cargo transport along microtubules (MTs) by interacting with kinesin-1 through the…”
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Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry-based de novo sequencing
Published in Life science alliance (01-06-2024)“…Mucin 1 (MUC1) is a transmembrane mucin expressed at the apical surface of epithelial cells at mucosal surfaces. MUC1 has a barrier function against bacterial…”
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CRTAC1 has a Compact β-propeller–TTR Core Stabilized by Potassium Ions
Published in Journal of molecular biology (15-09-2024)“…[Display omitted] •CRTAC1 aids nervous system regeneration but is unstable and aggregates covalently.•CRTAC1 is completely stabilized by potassium ions.•The…”
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Structural Basis for Recognition of the FLAG-tag by Anti-FLAG M2
Published in Journal of molecular biology (15-08-2024)“…[Display omitted] •The FLAG-tag is a widely used tool for protein identification and purification.•We report a crystal structure of the anti-FLAG M2 Fab in…”
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Teneurin4 dimer structures reveal a calcium‐stabilized compact conformation supporting homomeric trans‐interactions
Published in The EMBO journal (02-05-2022)“…Establishment of correct synaptic connections is a crucial step during neural circuitry formation. The Teneurin family of neuronal transmembrane proteins…”
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Contactin 2 homophilic adhesion structure and conformational plasticity
Published in Structure (London) (04-01-2024)“…The cell-surface attached glycoprotein contactin 2 is ubiquitously expressed in the nervous system and mediates homotypic cell-cell interactions to organize…”
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