Search Results - "Betz, Ulrich A K"

Site-Specific Conjugation of Native Antibodies Using Engineered Microbial Transglutaminases by Dickgiesser, Stephan, Rieker, Marcel, Mueller-Pompalla, Dirk, Schröter, Christian, Tonillo, Jason, Warszawski, Shira, Raab-Westphal, Sabine, Kühn, Stefanie, Knehans, Tim, Könning, Doreen, Dotterweich, Julia, Betz, Ulrich A. K, Anderl, Jan, Hecht, Stefan, Rasche, Nicolas

“…Site-specific bioconjugation technologies are frequently employed to generate homogeneous antibody–drug conjugates (ADCs) and are generally considered superior…”
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High Levels of Cre Expression in Neuronal Progenitors Cause Defects in Brain Development Leading to Microencephaly and Hydrocephaly by Forni, Paolo E, Scuoppo, Claudio, Imayoshi, Itaru, Taulli, Riccardo, Dastru, Walter, Sala, Valentina, Betz, Ulrich A. K, Muzzi, Patrizia, Martinuzzi, Daniela, Vercelli, Alessandro E, Kageyama, Ryoichiro, Ponzetto, Carola

“…Hydrocephalus is a common and variegated pathology often emerging in newborn children after genotoxic insults during pregnancy (Hicks and D'Amato, 1980). Cre…”
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Innovation and Team Spirit: The Magic of Science Competitions Seen through the Lens of the Compound Challenge by Seipp, Charles A., Monks, Brendan Michael, Karnysh, Iuliia, Betz, Ulrich A. K.

“…For five years now, Merck KGaA, Darmstadt, Germany has hosted The Compound Challenge—a global retrosynthesis competition. When the event kicked off in 2018 on…”
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PROLinkSingle Step Circularization and Purification Procedure for the Generation of an Improved Variant of Human Growth Hormone by Rasche, Nicolas, Tonillo, Jason, Rieker, Marcel, Becker, Stefan, Dorr, Brent, Ter-Ovanesyan, Dmitry, Betz, Ulrich A. K, Hock, Björn, Kolmar, Harald

“…Human growth hormone (hGH) plays an important role during human development and is also an approved therapeutic for the treatment of several diseases. However,…”
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Portfolio management in early stage drug discovery – a traveler's guide through uncharted territory by Betz, Ulrich A.K.

“…Portfolio management in drug development has become a best practice in the pharmaceutical industry. By contrast, early on in the value chain – the discovery…”
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Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier by Arima, Yasunobu, Harada, Masaya, Kamimura, Daisuke, Park, Jin-Haeng, Kawano, Fuminori, Yull, Fiona E., Kawamoto, Tadafumi, Iwakura, Yoichiro, Betz, Ulrich A.K., Márquez, Gabriel, Blackwell, Timothy S., Ohira, Yoshinobu, Hirano, Toshio, Murakami, Masaaki

“…Although it is believed that neural activation can affect immune responses, very little is known about the neuroimmune interactions involved, especially the…”
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Potent In Vivo Antiviral Activity of the Herpes Simplex Virus Primase-Helicase Inhibitor BAY 57-1293 by BETZ, Ulrich A. K, FISCHER, Rüdiger, KLEYMANN, Gerald, HENDRIX, Martin, RÜBSAMEN-WAIGMANN, Helga

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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IL-6-gp130-STAT3 in T cells directs the development of IL-17+ T[sub]h with a minimum effect on that of Treg in the steady state by Nishihara, Mika, Ogura, Hideki, Ueda, Naoko, Tsuruoka, Mineko, Kitabayashi, Chika, Tsuji, Fumio, Aono, Hiroyuki, Ishihara, Katsuhiko, Huseby, Eric, Betz, Ulrich A K, Murakami, Masaaki, Hirano, Toshio

“…IL-17-producing Th (Th 17) comprise a distinct lineage of pro-inflammatory Th that are major contributors to autoimmune diseases. Treatment with IL-6 and…”
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Is the force awakening? by Betz, Ulrich A.K.

“…Scientific and technological progress over the centuries was very strong in some fields, much weaker in others and even virtually absent in a few so far. For…”
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Locked by Design: A Conformationally Constrained Transglutaminase Tag Enables Efficient Site-Specific Conjugation by Siegmund, Vanessa, Schmelz, Stefan, Dickgiesser, Stephan, Beck, Jan, Ebenig, Aileen, Fittler, Heiko, Frauendorf, Holm, Piater, Birgit, Betz, Ulrich A. K., Avrutina, Olga, Scrima, Andrea, Fuchsbauer, Hans-Lothar, Kolmar, Harald

“…Based on the crystal structure of a natural protein substrate for microbial transglutaminase, an enzyme that catalyzes protein crosslinking, a recognition…”
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Target 2035 - an update on private sector contributions by Ackloo, Suzanne, Antolin, Albert A, Bartolome, Jose Manuel, Beck, Hartmut, Bullock, Alex, Betz, Ulrich A. K, Böttcher, Jark, Brown, Peter J, Chaturvedi, Menorca, Crisp, Alisa, Daniels, Danette, Dreher, Jan, Edfeldt, Kristina, Edwards, Aled M, Egner, Ursula, Elkins, Jon, Fischer, Christian, Glendorf, Tine, Goldberg, Steven, Hartung, Ingo V, Hillisch, Alexander, Homan, Evert, Knapp, Stefan, Köster, Markus, Krämer, Oliver, Llaveria, Josep, Lessel, Uta, Lindemann, Sven, Linderoth, Lars, Matsui, Hisanori, Michel, Maurice, Montel, Florian, Mueller-Fahrnow, Anke, Müller, Susanne, Owen, Dafydd R, Saikatendu, Kumar Singh, Santhakumar, Vijayaratnam, Sanderson, Wendy, Scholten, Cora, Schapira, Matthieu, Sharma, Sujata, Shireman, Brock, Sundström, Michael, Todd, Matthew H, Tredup, Claudia, Venable, Jennifer, Willson, Timothy M, Arrowsmith, Cheryl H

“…Target 2035, an international federation of biomedical scientists from the public and private sectors, is leveraging 'open' principles to develop a…”
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Synthetic Biology Category Wins the 350th Anniversary Merck Innovation Cup by Matos, Ângelo P., Kauffman, Amy, Vickery, Christopher, Naegeli, Kaleb, Strittmatter, Lisa, Sybirna, Anastasiya, van Blijswijk, Janneke, Adlung, Lorenz, Berbasova, Tetyana, Enterina, Jhon, Eismann, Lena, Tierney, Braden, Jordi, Josua, Zhu, Lian, Verkuijl, Sebald, Tallorin, Lorillee, Wehling, Arne, Ogden, Michael, Lammel, Stephan, Hasslacher, Maike K., Wuelfroth, Petra, Neumann, Siegfried, Tidona, Christian, Betz, Ulrich A.K.

“…Over the past 350 years, Merck has developed science and technology especially in health care, life sciences, and performance materials. To celebrate so many…”
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IFN-γ expression in CD8+ T cells regulated by IL-6 signal is involved in superantigen-mediated CD4+ T cell death by Atsumi, Toru, Sato, Masae, Kamimura, Daisuke, Moroi, Arisa, Iwakura, Yoichiro, Betz, Ulrich A. K., Yoshimura, Akihiko, Nishihara, Mika, Hirano, Toshio, Murakami, Masaaki

“…Infection with pathogens containing superantigens (Sags) can result in massive excessive CD4+ T cell activation and death in such conditions as toxic shock,…”
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The Darmstadt Science Declaration: Make Science Not War by Betz, Ulrich A. K.

“…“… We will only be able to solve significant challenges with further progress in science and technology applied to the benefit of humanity. The Darmstadt…”
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Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication by Garcia, Gustavo, Sharma, Arun, Ramaiah, Arunachalam, Sen, Chandani, Purkayastha, Arunima, Kohn, Donald B., Parcells, Mark S., Beck, Sebastian, Kim, Heeyoung, Bakowski, Malina A., Kirkpatrick, Melanie G., Riva, Laura, Wolff, Karen C., Han, Brandon, Yuen, Constance, Ulmert, David, Purbey, Prabhat K., Scumpia, Philip, Beutler, Nathan, Rogers, Thomas F., Chatterjee, Arnab K., Gabriel, Gülsah, Bartenschlager, Ralf, Gomperts, Brigitte, Svendsen, Clive N., Betz, Ulrich A.K., Damoiseaux, Robert D., Arumugaswami, Vaithilingaraja

“…SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a medium-throughput drug-screening system and identified a small-molecule…”
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Innovation and Team Spirit: The Magic of Science Competitions Seen through the Lens of the Compound Challenge by Seipp, Charles A., Monks, Brendan Michael, Karnysh, Iuliia, Betz, Ulrich A. K.

“…For five years now, Merck KGaA, Darmstadt, Germany has hosted The Compound Challenge—a global retrosynthesis competition. When the event kicked off in 2018 on…”
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Mice Reconstituted with DNA Polymerase β -Deficient Fetal Liver Cells Are Able to Mount a T Cell-Dependent Immune Response and Mutate Their Ig Genes Normally by Esposito, Gloria, Texido, Gemma, Ulrich A. K. Betz, Gu, Hua, Muller, Werner, Klein, Ulf, Rajewsky, Klaus

“…The ubiquitously expressed, error-prone DNA polymerase β (polβ) plays a role in base excision repair, and the involvement of this molecule in the nonhomologous…”
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Spontaneous Isopeptide Bond Formation as a Powerful Tool for Engineering Site-Specific Antibody-Drug Conjugates by Siegmund, Vanessa, Piater, Birgit, Zakeri, Bijan, Eichhorn, Thomas, Fischer, Frank, Deutsch, Carl, Becker, Stefan, Toleikis, Lars, Hock, Björn, Betz, Ulrich A. K., Kolmar, Harald

“…Spontaneous isopeptide bond formation, a stabilizing posttranslational modification that can be found in gram-positive bacterial cell surface proteins, has…”
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Target 2035 - update on the quest for a probe for every protein by Müller, Susanne, Ackloo, Suzanne, Al Chawaf, Arij, Al-Lazikani, Bissan, Antolin, Albert, Baell, Jonathan B, Beck, Hartmut, Beedie, Shaunna, Betz, Ulrich A K, Bezerra, Gustavo Arruda, Brennan, Paul E, Brown, David, Brown, Peter J, Bullock, Alex N, Carter, Adrian J, Chaikuad, Apirat, Chaineau, Mathilde, Ciulli, Alessio, Collins, Ian, Dreher, Jan, Drewry, David, Edfeldt, Kristina, Edwards, Aled M, Egner, Ursula, Frye, Stephen V, Fuchs, Stephen M, Hall, Matthew D, Hartung, Ingo V, Hillisch, Alexander, Hitchcock, Stephen H, Homan, Evert, Kannan, Natarajan, Kiefer, James R, Knapp, Stefan, Kostic, Milka, Kubicek, Stefan, Leach, Andrew R, Lindemann, Sven, Marsden, Brian D, Matsui, Hisanori, Meier, Jordan L, Merk, Daniel, Michel, Maurice, Morgan, Maxwell R, Mueller-Fahrnow, Anke, Owen, Dafydd R, Perry, Benjamin G, Rosenberg, Saul H, Saikatendu, Kumar Singh, Schapira, Matthieu, Scholten, Cora, Sharma, Sujata, Simeonov, Anton, Sundström, Michael, Superti-Furga, Giulio, Todd, Matthew H, Tredup, Claudia, Vedadi, Masoud, von Delft, Frank, Willson, Timothy M, Winter, Georg E, Workman, Paul, Arrowsmith, Cheryl H

“…Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. The challenge of…”
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Surveying the future of science, technology and business – A 35 year perspective by Betz, Ulrich A.K., Betz, Frederick, Kim, Rachel, Monks, Brendan, Phillips, Fred

“…We asked readers of Science, Nature and Harvard Business Review about their expectations for advances in science, technology, and business over a 35-year time…”
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