Search Results - "Betz, S F"

Disulfide bonds and the stability of globular proteins by Betz, Stephen F.

“…An understanding of the forces that contribute to stability is pivotal in solving the protein‐folding problem. Classical theory suggests that disulfide bonds…”
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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer by Oost, Thorsten K, Sun, Chaohong, Armstrong, Robert C, Al-Assaad, Ali-Samer, Betz, Stephen F, Deckwerth, Thomas L, Ding, Hong, Elmore, Steven W, Meadows, Robert P, Olejniczak, Edward T, Oleksijew, Andrew, Oltersdorf, Tilman, Rosenberg, Saul H, Shoemaker, Alexander R, Tomaselli, Kevin J, Zou, Hua, Fesik, Stephen W

“…Inhibitor of apoptosis (IAP) proteins are overexpressed in many cancers and have been implicated in tumor growth, pathogenesis, and resistance to chemo- or…”
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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain by Fesik, Stephen W, Liu, Zhihong, Sun, Chaohong, Olejniczak, Edward T, Meadows, Robert P, Betz, Stephen F, Oost, Thorsten, Herrmann, Julia, Wu, Joe C

“…The inhibitor-of-apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. Recently, a mammalian protein…”
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The Crystal Structure of a Quercetin 2,3-Dioxygenase from Bacillus subtilis Suggests Modulation of Enzyme Activity by a Change in the Metal Ion at the Active Site(s) by Gopal, B, Madan, Lalima L, Betz, Stephen F, Kossiakoff, Anthony A

“…Common structural motifs, such as the cupin domains, are found in enzymes performing different biochemical functions while retaining a similar active site…”
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Safety and Advantages of Bacillus thuringiensis-Protected Plants to Control Insect Pests by Betz, Fred S, Hammond, Bruce G, Fuchs, Roy L

“…Plants modified to express insecticidal proteins from Bacillus thuringiensis (referred to as Bt-protected plants) provide a safe and highly effective method of…”
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Protein Design: A Hierarchic Approach by Bryson, James W., Betz, Stephen F., Lu, Helen S., Suich, Daniel J., Zhou, Hongxing X., O'Neil, Karyn T., DeGrado, William F.

“…The de novo design of peptides and proteins has recently emerged as an approach for investigating protein structure and function. Designed, helical peptides…”
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Introduction of a disulfide bond into cytochrome c stabilizes a compact denatured state by Betz, Stephen F, Pielak, Gary J

“…We introduced a novel disulfide bond, modeled on that of bullfrog cytochrome c, into yeast iso-1-cytochrome c. The disulfide spontaneously forms upon…”
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Amide proton exchange rates of oxidized and reduced saccharomyces cerevisiae iso‐1‐cytochrome c by Marmorino, Jennifer L., Auld, Douglas S., Betz, Stephen F., Doyle, Donald F., Young, Gregory B., Pielak, Gary J.

“…Proton NMR spectroscopy was used to determine the rate constant, kobs, for exchange of labile protons in both oxidized (Fe(III)) and reduced (Fe(II))…”
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Controlling Topology and Native-like Behavior of de Novo-Designed Peptides:  Design and Characterization of Antiparallel Four-Stranded Coiled Coils by Betz, Stephen F, DeGrado, William F

“…The de novo design of peptides and proteins has emerged as an attractive approach for investigating protein structure and function. Here, the design,…”
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De Novo Design of Native Proteins:  Characterization of Proteins Intended To Fold into Antiparallel, Rop-like, Four-Helix Bundles by Betz, Stephen F, Liebman, Paul A, DeGrado, William F

“…The de novo design and characterization of a series of 51-residue helix−turn−helix peptides intended to dimerize into antiparallel four-stranded coiled coils…”
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Probing weakly polar interactions in cytochrome c by Auld, Douglas S., Young, Gregory B., Saunders, Aleister J., Doyle, Donald F., Betz, Stephen F., Pielak, Gary J.

“…Theoretical, statistical, and model studies suggest that proteins are stabilized by weakly polar attractions between sulfur atoms and properly oriented…”
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Native-like and structurally characterized designed α-helical bundles by Betz, Stephen F, Bryson, James W, DeGrado, William F

“…A number of coiled coils and α-helical bundles have recently been designed, and many have now been structurally characterized by X-ray crystallography. Others…”
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Changes in global stability and local structure of cytochrome c upon substituting phenylalanine-82 with tyrosine by Greene, R M, Betz, S F, Hilgen-Willis, S, Auld, D S, Fencl, J B, Pielak, G J

“…We have examined the F82Y;C102T variant of Saccharomyces cerevisiae iso-1-cytochrome c using high-resolution proton nuclear magnetic resonance spectroscopy,…”
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Hydrophobic Core Malleability of a De Novo Designed Three-helix Bundle Protein by Walsh, Scott T.R., Sukharev, Vladislav I., Betz, Stephen F., Vekshin, Nikolai L., DeGrado, William F.

“…De novo protein design provides a tool for testing the principles that stabilize the structures of proteins. Recently, we described the design and structure…”
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Function first: a powerful approach to post-genomic drug discovery by Betz, Stephen F., Baxter, Susan M., Fetrow, Jacquelyn S.

“…In the post-genomic era, pharmaceutical researchers must evaluate vast numbers of protein sequences and formulate novel, intelligent strategies for identifying…”
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9330 Atumelnant (crn04894) Induces Rapid And Sustained Reductions In Serum And Urine Cortisol In Patients With Acth-Dependent Cushing Syndrome During A Phase 1b/2a, Single Center, 10-day, Inpatient, Open-Label Study by Elenius, H, McGlotten, R, Moore, C, Omotosho, Y B, Ayala, A, Wu, Y, Trainer, P J, Struthers, R S, Krasner, A, Betz, S F, Nieman, L K

“…Disclosure: H. Elenius: Grant Recipient; Self; Crinetics Pharmaceuticals, Inc. R. McGlotten: Grant Recipient; Self; Crinetics Pharmaceuticals, Inc. C. Moore:…”
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Expression of de novo designed alpha-helical bundles by Betz, S F, Bryson, J W, Passador, M C, Brown, R J, O'Neil, K T, DeGrado, W F

“…The successful design of proteins requires careful consideration of the multiplicity of forces that stabilize their three-dimensional structures including…”
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Solution Structure of the Cytohesin-1 (B2-1) Sec7 Domain and Its Interaction with the GTPase ADP Ribosylation Factor 1 by Betz, Stephen F., Schnuchel, Arndt, Wang, Hong, Olejniczak, Edward T., Meadows, Robert P., Lipsky, Brian P., Edith A. S. Harris, Staunton, Donald E., Fesik, Stephen W.

“…Cytohesin-1 (B2-1) is a guanine nucleotide exchange factor for human ADP ribosylation factor (Arf) GTPases, which are important for vesicular protein…”
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Unusual Effects of an Engineered Disulfide on Global and Local Protein Stability by Betz, Stephen F, Marmorino, Jennifer L, Saunders, Aleister J, Doyle, Donald F, Young, Gregory B, Pielak, Gary J

“…The global and local stabilities of a eukaryotic ferricytochrome c variant with an engineered disulfide are examined. The disulfide connects position 20, which…”
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Protein thermal denaturation, side-chain models, and evolution: amino acid substitutions at a conserved helix-helix interface by Pielak, Gary J, Auld, Douglas S, Beasley, James R, Betz, Stephen F, Cohen, David S, Doyle, Donald F, Finger, Shelley A, Fredericks, Zoey L, Hilgen-Willis, Sharon

“…Random mutant libraries with substitutions at the interface between the N- and C-terminal helices of Saccharomyces cerevisiae iso-1-cytochrome c were screened…”
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