Search Results - "Betts, Michael"

T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection by Buggert, Marcus, Tauriainen, Johanna, Yamamoto, Takuya, Frederiksen, Juliet, Ivarsson, Martin A, Michaëlsson, Jakob, Lund, Ole, Hejdeman, Bo, Jansson, Marianne, Sönnerborg, Anders, Koup, Richard A, Betts, Michael R, Karlsson, Annika C

“…CD8(+) T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8(+) T cell differentiation, T-bet and…”
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Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications by Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John

“…Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional…”
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Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy by Apostolidis, Sokratis A., Kakara, Mihir, Painter, Mark M., Goel, Rishi R., Mathew, Divij, Lenzi, Kerry, Rezk, Ayman, Patterson, Kristina R., Espinoza, Diego A., Kadri, Jessy C., Markowitz, Daniel M., E. Markowitz, Clyde, Mexhitaj, Ina, Jacobs, Dina, Babb, Allison, Betts, Michael R., Prak, Eline T. Luning, Weiskopf, Daniela, Grifoni, Alba, Lundgreen, Kendall A., Gouma, Sigrid, Sette, Alessandro, Bates, Paul, Hensley, Scott E., Greenplate, Allison R., Wherry, E. John, Li, Rui, Bar-Or, Amit

“…SARS-CoV-2 messenger RNA vaccination in healthy individuals generates immune protection against COVID-19. However, little is known about SARS-CoV-2 mRNA…”
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Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination by Painter, Mark M., Mathew, Divij, Goel, Rishi R., Apostolidis, Sokratis A., Pattekar, Ajinkya, Kuthuru, Oliva, Baxter, Amy E., Herati, Ramin S., Oldridge, Derek A., Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Lundgreen, Kendall A., Kuri-Cervantes, Leticia, Adamski, Sharon, Hicks, Amanda, Korte, Scott, Giles, Josephine R., Weirick, Madison E., McAllister, Christopher M., Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., Betts, Michael R., Bates, Paul, Hensley, Scott E., Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Greenplate, Allison R., Wherry, E. John

“…SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming. We performed…”
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Multivariate indicators of disease severity in COVID-19 by Bean, Joe, Kuri-Cervantes, Leticia, Pennella, Michael, Betts, Michael R., Meyer, Nuala J., Hassan, Wail M.

“…The novel coronavirus pandemic continues to cause significant morbidity and mortality around the world. Diverse clinical presentations prompted numerous…”
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Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection by Anderson, Elizabeth M., Goodwin, Eileen C., Verma, Anurag, Arevalo, Claudia P., Bolton, Marcus J., Weirick, Madison E., Gouma, Sigrid, McAllister, Christopher M., Christensen, Shannon R., Weaver, JoEllen, Hicks, Philip, Manzoni, Tomaz B., Oniyide, Oluwatosin, Ramage, Holly, Mathew, Divij, Baxter, Amy E., Oldridge, Derek A., Greenplate, Allison R., Wu, Jennifer E., Alanio, Cécile, D’Andrea, Kurt, Kuthuru, Oliva, Dougherty, Jeanette, Pattekar, Ajinkya, Kim, Justin, Han, Nicholas, Apostolidis, Sokratis A., Huang, Alex C., Vella, Laura A., Kuri-Cervantes, Leticia, Pampena, M. Betina, Betts, Michael R., Wherry, E. John, Meyer, Nuala J., Cherry, Sara, Bates, Paul, Rader, Daniel J., Hensley, Scott E.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most…”
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Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease by Fajgenbaum, David C, Langan, Ruth-Anne, Japp, Alberto Sada, Partridge, Helen L, Pierson, Sheila K, Singh, Amrit, Arenas, Daniel J, Ruth, Jason R, Nabel, Christopher S, Stone, Katie, Okumura, Mariko, Schwarer, Anthony, Jose, Fábio Freire, Hamerschlak, Nelson, Wertheim, Gerald B, Jordan, Michael B, Cohen, Adam D, Krymskaya, Vera, Rubenstein, Arthur, Betts, Michael R, Kambayashi, Taku, van Rhee, Frits, Uldrick, Thomas S

“…Idiopathic multicentric Castleman disease (iMCD) is a hematologic illness involving cytokine-induced lymphoproliferation, systemic inflammation, cytopenias,…”
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The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans by Johnson, John L., Rosenthal, Rebecca L., Knox, James J., Myles, Arpita, Naradikian, Martin S., Madej, Joanna, Kostiv, Mariya, Rosenfeld, Aaron M., Meng, Wenzhao, Christensen, Shannon R., Hensley, Scott E., Yewdell, Jonathan, Canaday, David H., Zhu, Jinfang, McDermott, Adrian B., Dori, Yoav, Itkin, Max, Wherry, E. John, Pardi, Norbert, Weissman, Drew, Naji, Ali, Prak, Eline T. Luning, Betts, Michael R., Cancro, Michael P.

“…B cell subsets expressing the transcription factor T-bet are associated with humoral immune responses and autoimmunity. Here, we examined the anatomic…”
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Human circulating and tissue-resident memory CD8+ T cells by Buggert, Marcus, Price, David A., Mackay, Laura K., Betts, Michael R.

“…Our current knowledge of human memory CD8 + T cells is derived largely from studies of the intravascular space. However, emerging data are starting to…”
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Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication by Pinkevych, Mykola, Docken, Steffen S, Okoye, Afam A, Fennessey, Christine M, Del Prete, Gregory Q, Pino, Maria, Harper, Justin L, Betts, Michael R, Paiardini, Mirko, Keele, Brandon F, Davenport, Miles P

“…One approach to 'functional cure' of HIV infection is to induce durable control of HIV replication after the interruption of antiretroviral therapy (ART)…”
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Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis by Novais, Fernanda O, Carvalho, Lucas P, Graff, Joel W, Beiting, Daniel P, Ruthel, Gordon, Roos, David S, Betts, Michael R, Goldschmidt, Michael H, Wilson, Mary E, de Oliveira, Camila I, Scott, Phillip

“…Disease progression in response to infection can be strongly influenced by both pathogen burden and infection-induced immunopathology. While current…”
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The CD4⁻CD8⁻ MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8⁺ MAIT cell pool by Dias, Joana, Boulouis, Caroline, Gorin, Jean-Baptiste, van den Biggelaar, Robin H. G. A., Lal, Kerri G., Gibbs, Anna, Loh, Liyen, Gulam, Muhammad Yaaseen, Sia, Wan Rong, Bari, Sudipto, Hwang, William Y. K., Nixon, Douglas F., Nguyen, Son, Betts, Michael R., Buggert, Marcus, Eller, Michael A., Broliden, Kristina, Tjernlund, Annelie, Sandberg, Johan K., Leeansyah, Edwin

“…Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the MHC class…”
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Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control by Hersperger, Adam R, Pereyra, Florencia, Nason, Martha, Demers, Korey, Sheth, Prameet, Shin, Lucy Y, Kovacs, Colin M, Rodriguez, Benigno, Sieg, Scott F, Teixeira-Johnson, Leia, Gudonis, Debbie, Goepfert, Paul A, Lederman, Michael M, Frank, Ian, Makedonas, George, Kaul, Rupert, Walker, Bruce D, Betts, Michael R

“…Many immune correlates of CD8(+) T-cell-mediated control of HIV replication, including polyfunctionality, proliferative ability, and inhibitory receptor…”
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Living in a house of cards: re-evaluating CD8+ T-cell immune correlates against HIV by Makedonas, George, Betts, Michael R.

“…The Merck STEP and the Thai RV144 human immunodeficiency virus (HIV) vaccine trials confirmed that we still have a long way to go before developing a…”
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Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency by Docken, Steffen S, McCormick, Kevin, Pampena, M Betina, Samer, Sadia, Lindemuth, Emily, Pinkevych, Mykola, Viox, Elise G, Wu, Yuhuang, Schlub, Timothy E, Cromer, Deborah, Keele, Brandon F, Paiardini, Mirko, Betts, Michael R, Bar, Katharine J, Davenport, Miles P

“…HIV rapidly rebounds after interruption of antiretroviral therapy (ART). HIV-specific CD8+ T cells may act to prevent early events in viral reactivation…”
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Comprehensive mapping of immune perturbations associated with severe COVID-19 by Kuri-Cervantes, Leticia, Pampena, M Betina, Meng, Wenzhao, Rosenfeld, Aaron M, Ittner, Caroline A G, Weisman, Ariel R, Agyekum, Roseline S, Mathew, Divij, Baxter, Amy E, Vella, Laura A, Kuthuru, Oliva, Apostolidis, Sokratis A, Bershaw, Luanne, Dougherty, Jeanette, Greenplate, Allison R, Pattekar, Ajinkya, Kim, Justin, Han, Nicholas, Gouma, Sigrid, Weirick, Madison E, Arevalo, Claudia P, Bolton, Marcus J, Goodwin, Eileen C, Anderson, Elizabeth M, Hensley, Scott E, Jones, Tiffanie K, Mangalmurti, Nilam S, Luning Prak, Eline T, Wherry, E John, Meyer, Nuala J, Betts, Michael R

“…Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we…”
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Coregulation of CD8 + T cell exhaustion by multiple inhibitory receptors during chronic viral infection by Shin, Haina, Haining, W Nicholas, Wherry, E John, Betts, Michael R, Polley, Antonio, Blackburn, Shawn D, Vignali, Dario A A, Zou, Tao, Workman, Creg J, Freeman, Gordon J

“…Chronic infection can lead to T cell exhaustion. Wherry and colleagues demonstrate that a hierarchy of inhibitory receptors coregulate CD8 + T cell exhaustion…”
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T-bet-expressing B cells during HIV and HCV infections by Knox, James J., Kaplan, David E., Betts, Michael R.

“…•Mouse and human studies suggest a role for T-bet+ B cells in antiviral immunity.•HIV and HCV maintain a large T-bet+ B cell population in viremic…”
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Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii by Dupont, Christopher D, Christian, David A, Selleck, Elizabeth M, Pepper, Marion, Leney-Greene, Michael, Harms Pritchard, Gretchen, Koshy, Anita A, Wagage, Sagie, Reuter, Morgan A, Sibley, L David, Betts, Michael R, Hunter, Christopher A

“…During infection with the intracellular parasite Toxoplasma gondii, the presentation of parasite-derived antigens to CD4+ and CD8+ T cells is essential for…”
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Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells by Adeniji, Opeyemi S, Kuri-Cervantes, Leticia, Yu, Chenfei, Xu, Ziyang, Ho, Michelle, Chew, Glen M, Shikuma, Cecilia, Tomescu, Costin, George, Ashley F, Roan, Nadia R, Ndhlovu, Lishomwa C, Liu, Qin, Muthumani, Kar, Weiner, David B, Betts, Michael R, Xiao, Han, Abdel-Mohsen, Mohamed

“…Siglec-9 is an MHC-independent inhibitory receptor expressed on a subset of natural killer (NK) cells. Siglec-9 restrains NK cytotoxicity by binding to…”
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