Search Results - "Betton, Graham"

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System by Frazier, Kendall S., Seely, John Curtis, Hard, Gordon C., Betton, Graham, Burnett, Roger, Nakatsuji, Shunji, Nishikawa, Akiyoshi, Durchfeld-Meyer, Beate, Bube, Axel

“…The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of…”
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Biological Qualification of Biomarkers of Chemical-Induced Renal Toxicity in Two Strains of Male Rat by Harpur, Ernie, Ennulat, Daniela, Hoffman, David, Betton, Graham, Gautier, Jean-Charles, Riefke, Bjoern, Bounous, Denise, Schuster, Kerstin, Beushausen, Sven, Guffroy, Magali, Shaw, Martin, Lock, Edward, Pettit, Syril

“…This study reports the evaluation of four urinary biomarkers of renal toxicity, α-glutathione-S-transferase (α-GST), μ-GST, clusterin, and renal papillary…”
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Biomarkers of Collecting Duct Injury in Han-Wistar and Sprague-Dawley Rats Treated with N-Phenylanthranilic Acid by Betton, Graham R., Ennulat, Daniela, Hoffman, David, Gautier, Jean-Charles, Harpur, Ernie, Pettit, Syril

“…N-phenylanthranilic acid is a chloride channel blocker that causes renal papillary necrosis in rats. Studies were conducted in two strains of male rats to…”
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Microarray analysis of gene expression of mouse hepatocytes of different ploidy by Lu, Pin, Prost, Sandrine, Caldwell, Helen, Tugwood, Jonathan D, Betton, Graham R, Harrison, David J

“…Polyploidisation in hepatocytes has been associated with many physiologic and pathologic processes such as proliferation, metabolism, regeneration, aging, and…”
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Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals by Olson, Harry, Betton, Graham, Robinson, Denise, Thomas, Karluss, Monro, Alastair, Kolaja, Gerald, Lilly, Patrick, Sanders, James, Sipes, Glenn, Bracken, William, Dorato, Michael, Van Deun, Koen, Smith, Peter, Berger, Bruce, Heller, Allen

“…This report summarizes the results of a multinational pharmaceutical company survey and the outcome of an International Life Sciences Institute (ILSI) Workshop…”
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Characterization of Renal Papillary Antigen 1 (RPA-1), a Biomarker of Renal Papillary Necrosis by Price, Sally A., Davies, Dai, Rowlinson, Rachel, Copley, Clive G., Roche, Andrew, Falkenberg, Frank W., Riccardi, Daniela, Betton, Graham R.

“…Renal papillary necrosis (RPN) is a relatively common toxicity observed in preclinical drug safety testing. It is also observed in a variety of human diseases…”
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Expression and Localization of Rat Aldo-Keto Reductases and Induction of the 1B13 and 1D2 Isoforms by Phenolic Antioxidants by MACLEOD, A. Kenneth, KELLY, Vincent P, HIGGINS, Larry G, KELLEHER, Michael O, PRICE, Sally A, BIGLEY, Alison L, BETTON, Graham R, HAYES, John D

“…The aldo-keto reductase (AKR) phase I drug metabolism enzyme superfamily is implicated in detoxification or bioactivation of a wide variety of carbonyl-bearing…”
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Biomarkers and Mechanisms of Drug-Induced Vascular Injury in Non-Rodents by Louden, Calvert, Brott, David, Katein, Anne, Kelly, Thomas, Gould, Sarah, Jones, Huw, Betton, Graham, Valetin, Jean-Pierre, Richardson, Rudy J.

“…In preclinical safety studies, drug-induced vascular injury can negatively impact candidate-drug selection because there are no obvious diagnostic markers for…”
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Application of Dolichos biflorus in immunoassay detection of kidney collecting duct biomarkers by Sourial, Samer, Searchfield, Lydia, Schuppe-Koistinen, Ina, Betton, Graham R., Riccardi, Daniela, Price, Sally A.

“…Currently there are no biomarkers for detecting collecting duct damage in man. Antibodies to several collecting duct-specific antigens exist but sandwich…”
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Protein biomarkers of nephrotoxicity; a review and findings with cyclosporin A, a signal transduction kinase inhibitor and N-phenylanthranilic acid by Betton, Graham R, Kenne, Kerstin, Somers, Rebecca, Marr, Andrew

“…Biomarkers of nephrotoxicity range from plasma and urine biochemistry, enzymic assays for brush border and lysosomal markers plus new protein markers by…”
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Endothelin Antagonist-Induced Coronary and Systemic Arteritis in the Beagle Dog by Jones, Huw B., Macpherson, Allen, Betton, Graham R., Davis, A. Stewart, Siddall, Robert, Greaves, Peter

“…Two endothelin antagonists, ZD1611 (3-{4-[3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)-2-pyridyl]phenyl }-2,2-dimethylpropanoic acid) and ZD2574…”
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Immunohistochemical Localization of RPA-1; Comment on Paper by Zhang et al., Toxicol Pathol 36;397 by Betton, Graham

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Towards consensus practices to qualify safety biomarkers for use in early drug development by Sistare, Frank D, Dieterle, Frank, Troth, Sean, Holder, Daniel J, Gerhold, David, Andrews-Cleavenger, Dina, Baer, William, Betton, Graham, Bounous, Denise, Carl, Kevin, Collins, Nathaniel, Goering, Peter, Goodsaid, Federico, Gu, Yi-Zhong, Guilpin, Valerie, Harpur, Ernie, Hassan, Alita, Jacobson-Kram, David, Kasper, Peter, Laurie, David, Lima, Beatriz Silva, Maciulaitis, Romaldas, Mattes, William, Maurer, Gérard, Obert, Leslie Ann, Ozer, Josef, Papaluca-Amati, Marisa, Phillips, Jonathan A, Pinches, Mark, Schipper, Matthew J, Thompson, Karol L, Vamvakas, Spiros, Vidal, Jean-Marc, Vonderscher, Jacky, Walker, Elizabeth, Webb, Craig, Yu, Yan

“…Application of any new biomarker to support safety-related decisions during regulated phases of drug development requires provision of a substantial data set…”
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Glutathione S-transferases as molecular markers of tumour progression and prognosis in renal cell carcinoma by Searchfield, Lydia, Price, Sally A, Betton, Graham, Jasani, Bharat, Riccardi, Daniela, Griffiths, David F R

“…Searchfield L, Price S A, Betton G, Jasani B, Riccardi D & Griffiths D F R
(2011) Histopathology58, 180–190
Glutathione S‐transferases as molecular markers of…”
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Glutathione S-transferases as molecular markers of tumor sub-type and prognosis in clinically confined renal cell carcinoma by Searchfield, Lydia E, Price, Sally A, Betton, Graham R, Jasani, Bharat, Riccardi, Daniela, Griffiths, David Fr

“…Aims. Renal cell carcinoma (RCC) often recurs as distant metastasis; there is thus a need for new indicators to identify high-risk patients. Glutathione…”
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Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System: International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Proliferative and Non-Proliferative Lesions of the Nervous and Urinary Systems of the Rat and Mouse by FRAZIER, Kendall S, SEELY, John Curtis, HARD, Gordon C, BETTON, Graham, BURNETT, Roger, NAKATSUJI, Shunji, NISHIKAWA, Akiyoshi, DURCHFELD-MEYER, Beate, BUBE, Axel

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Imaging Kidney in Conscious Rats with High-Frequency Ultrasound and Detection of Two Cases of Unilateral Congenital Hydronephrosis by Wang, Yi-Xiang J, Betton, Graham, Floettmann, Eike, Fantham, Elizabeth, Ridgwell, Graham

“…Abstract A quick noninvasive screen of laboratory animal organ phenotype by high-resolution ultrasound is useful in biomedical research and new drug discovery…”
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Gastric ECL-cell hyperplasia and carcinoids in rodents following chronic administration of H2-antagonists SK&F 93479 and oxmetidine and omeprazole by Betton, G R, Dormer, C S, Wells, T, Pert, P, Price, C A, Buckley, P

“…The histamine H2-receptor antagonist SK&F 93479 induced gastric neuroendocrine (carcinoid) ECL-cell tumor formation in 6/34 male and 8/37 female rats treated…”
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MRI histopathology correlation of N-phenylanthranilic acid induced nephropathy in rats by Wang, Yi-Xiang J, Betton, Graham, Floettmann, Eike, Liess, Carsten

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The predictivity of the toxicity of pharmaceuticals in humans from animal data — an interim assessment by Olson, Harry, Betton, Graham, Stritar, Jeffrey, Robinson, Denise

“…This project was undertaken by the International Life Sciences Institute's Health and Environmental Sciences Institute (ILSI-HESI) to develop an improved…”
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