Search Results - "Betton, G."

A review of the toxicology and pathology of the gastrointestinal tract by Betton, G. R.

“…The gastrointestinal tract of man and animals shows great specialization in structure and function for its primary role of digestion. There are many species…”
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Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals by Olson, Harry, Betton, Graham, Robinson, Denise, Thomas, Karluss, Monro, Alastair, Kolaja, Gerald, Lilly, Patrick, Sanders, James, Sipes, Glenn, Bracken, William, Dorato, Michael, Van Deun, Koen, Smith, Peter, Berger, Bruce, Heller, Allen

“…This report summarizes the results of a multinational pharmaceutical company survey and the outcome of an International Life Sciences Institute (ILSI) Workshop…”
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Biomarkers of drug-induced vascular injury by Brott, D., Gould, S., Jones, H., Schofield, J., Prior, H., Valentin, J.P, Bjurstrom, S., Kenne, K., Schuppe-Koistinen, I., Katein, A., Foster-Brown, L., Betton, G., Richardson, R., Evans, G., Louden, C.

“…In pre-clinical safety studies, drug-induced vascular injury is an issue of concern because there are no obvious diagnostic markers for pre-clinical or…”
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Endothelin Antagonist-Induced Coronary and Systemic Arteritis in the Beagle Dog by Jones, Huw B., Macpherson, Allen, Betton, Graham R., Davis, A. Stewart, Siddall, Robert, Greaves, Peter

“…Two endothelin antagonists, ZD1611 (3-{4-[3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)-2-pyridyl]phenyl }-2,2-dimethylpropanoic acid) and ZD2574…”
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Self-control mechanism for performance evaluation in high school students in Mexico by Nieto-Jalil, Jose M., Betton, L. G. Florent

“…The use of artificial intelligence and machine learning allows us to define better strategies to investigate the general performance of each student and…”
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Gastric ECL-cell hyperplasia and carcinoids in rodents following chronic administration of H2-antagonists SK&F 93479 and oxmetidine and omeprazole by Betton, G R, Dormer, C S, Wells, T, Pert, P, Price, C A, Buckley, P

“…The histamine H2-receptor antagonist SK&F 93479 induced gastric neuroendocrine (carcinoid) ECL-cell tumor formation in 6/34 male and 8/37 female rats treated…”
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Coronary vascular lesions in dogs treated with phosphodiesterase III inhibitors by Isaacs, K R, Joseph, E C, Betton, G R

“…A treatment-related coronary arteriopathy has been observed in the dog following the oral or intravenous administration of 4 potent phosphodiesterase type III…”
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A critical review of the optimum duration of chronic rodent testing for the determination of non-tumourigenic toxic potential: a report by the BTS Working Party on Duration of Toxicity Testing by Betton, G, Cockburn, A, Harpur, E, Hopkins, J, Illing, P, Lumley, C, Connors, T

“…This review indicates that for the detection of non-neoplastic toxic effects: 1. Four decades of accumulated literature provide no lead as to the optimum…”
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Spontaneous neoplasms of the marmoset (Callithrix jacchus). Oral and nasopharyngeal squamous cell carcinomas by Betton, G R

“…Eight spontaneous highly invasive oral and nasopharyngeal squamous cell carcinomas were observed over an 18-month period in a breeding colony of the common…”
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AN OVERVIEW OF ANIMAL TOXICOLOGY STUDIES WITH BICALUTAMIDE (ICI 176, 334) by ISWARAN, T.J., IMAI, M., BETTON, G.R., SIDDALL, R.A.

“…The toxicological profile of bicalutamide in animals following acute and chronic dosing is closely associated with the drug's non-steroidal anti-androgenic…”
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Gastric neuroendocrine cell hyperplasia after treatment with the long-acting, potent H2-receptor antagonist SK&F 93479 by Harleman, J H, Betton, G R, Dormer, C, McCrossan, M

“…The time course and dose response of the neuroendocrine cell hyperplasia in the oxyntic mucosa of the rat was examined after treatment with the potent,…”
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Agglutination reactions of spontaneous canine tumour cells, induced by concanavalin A, demonstrated by an isotopic assay by Betton, G R

“…Quantitative assessment of the agglutination of 51Cr labelled canine cell suspensions to canine kidney cell monolayers has been performed over a range of…”
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Biomarkers and Mechanisms of Drug-Induced Vascular Injury in Non-Rodents by Louden, Calvert, Brott, David, Katein, Anne, Kelly, Thomas, Gould, Sarah, Jones, Huw, Betton, Graham, Valetin, Jean-Pierre, Richardson, Rudy J.

“…In preclinical safety studies, drug-induced vascular injury can negatively impact candidate-drug selection because there are no obvious diagnostic markers for…”
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Identification of viral inclusions in the papillary collecting duct epithelium of the dog by Betton, G R

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The predictivity of the toxicity of pharmaceuticals in humans from animal data — an interim assessment by Olson, Harry, Betton, Graham, Stritar, Jeffrey, Robinson, Denise

“…This project was undertaken by the International Life Sciences Institute's Health and Environmental Sciences Institute (ILSI-HESI) to develop an improved…”
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Cell-mediated responses in dogs with spontaneous neoplasms. I. Detection of cell-mediated cytotoxicity by the chromium-51 release assay by Betton, G R, Gorman, N T

“…A series of 43 dogs with spontaneous melanomas, sarcomas, or mammary carcinomas were tested for peripheral blood lymphocytotoxicity against a range of…”
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Allogeneic grafts of spontaneous canine melanomas and their cell culture strains in neonatal immunosuppressed dogs by Betton, G R, Owen, L N

“…Canine melanoma has been transplanted to allogeneic neonatal recipients receiving continuous immunosuppression with anti-lymphocyte serum. One spontaneous…”
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Cell-mediated responses in dogs with spontaneous neoplasms. II. Detection by direct leukocyte migration inhibition technique by Gorman, N T, Betton, G R

“…A series of 39 dogs bearing spontaneous mammary carcinomas or melanomas were tested for tumor-directed immune response against allogeneic Formalin-treated…”
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Cell mediated cytotoxicity in dogs following systemic or local BCG treatment alone or in combination with allogeneic tumour cell lines by Betton, G R, Gorman, N T, Owen, L N

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Proceedings: The growth of spontaneous melanoma allografts in immunosuppressed neonatal dogs by Betton, G R, Owen, L N

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