Search Results - "Bettina, Bongiovanni"
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Increased levels of circulating LPS during Tuberculosis prevails in patients with advanced pulmonary involvement
Published in PloS one (10-09-2021)“…Our earlier studies in tuberculosis (TB) patients indicate that in those where the process evolves to a larger pulmonary involvement, the immune endocrine…”
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The Immunoregulatory Actions of DHEA in Tuberculosis, A Tool for Therapeutic Intervention?
Published in Frontiers in endocrinology (Lausanne) (06-06-2022)“…Dehydroepiandrosterone (DHEA) is an androgen synthesized by the adrenal cortex, which is an intermediary in the biosynthesis of sex hormones, such as…”
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Studies on the contribution of PPAR Gamma to tuberculosis physiopathology
Published in Frontiers in cellular and infection microbiology (28-04-2023)“…Tuberculosis (TB) is a major health problem characterized by an immuno-endocrine imbalance: elevated plasma levels of cortisol and pro- and anti-inflammatory…”
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Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology
Published in Frontiers in endocrinology (Lausanne) (01-05-2018)“…Upon the pathogen encounter, the host seeks to ensure an adequate inflammatory reaction to combat infection but at the same time tries to prevent collateral…”
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Evidence for a More Disrupted Immune-Endocrine Relation and Cortisol Immunologic Influences in the Context of Tuberculosis and Type 2 Diabetes Comorbidity
Published in Frontiers in endocrinology (Lausanne) (20-03-2020)“…Pulmonary tuberculosis (PTB), caused by ( ), is a major health problem worldwide, further aggravated by the convergence of type 2 diabetes mellitus (DM) which…”
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Increased Frequency of CD4+ CD25+ FoxP3+ T Regulatory Cells in Pulmonary Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile
Published in Journal of immunology research (01-01-2015)“…Tuberculosis (TB) is a major health problem requiring an appropriate cell immune response (IR) to be controlled. Since regulatory T cells (Tregs) are relevant…”
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Differential expression of genes regulated by the glucocorticoid receptor pathway in patients with pulmonary tuberculosis
Published in Life sciences (1973) (15-07-2022)“…Previous studies in TB patients showed an immuno-endocrine imbalance characterized by a disease-severity associated increase in plasma levels of…”
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The relationship between host defense peptides and adrenal steroids. An account of reciprocal influences
Published in Cytokine (Philadelphia, Pa.) (01-08-2023)“…[Display omitted] •DHEA increase M tuberculosis clearance in macrophages infected.•DHEA increase antimicrobial peptides in macrophages infected with M…”
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Evidence that changes in antimicrobial peptides during tuberculosis are related to disease severity, clinical presentation, specific therapy and levels of immune-endocrine mediators
Published in Cytokine (Philadelphia, Pa.) (01-02-2020)“…[Display omitted] Given the role of host defense peptides (HDPs) in the defensive response against mycobacteria, we analyzed the circulating levels of LL-37,…”
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Effect of cortisol and/or DHEA on THP1-derived macrophages infected with Mycobacterium tuberculosis
Published in Tuberculosis (Edinburgh, Scotland) (01-09-2015)“…Summary Tuberculosis (TB) is a major health problem requiring an appropriate cell immune response to be controlled. Macrophages play a central role in the…”
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The clinical recovery of tuberculosis patients undergoing specific treatment is associated with changes in the immune and neuroendocrine responses
Published in Pathogens and disease (29-09-2017)“…Abstract Tuberculosis (TB) caused by Mycobacterium tuberculosis is a health problem worldwide. Patients with pulmonary TB show a neuro-immune-endocrine…”
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miR-30c is specifically repressed in patients with active pulmonary tuberculosis
Published in Tuberculosis (Edinburgh, Scotland) (01-07-2017)“…Tuberculous pleurisy (PLTB) is a common form of extrapulmonary tuberculosis. It often resolves without chemotherapy being hence considered a rather benign…”
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miR-30cis specifically repressed in patients with active pulmonary tuberculosis
Published in Tuberculosis (Edinburgh, Scotland) (2017)“…Abstract Tuberculous pleurisy (PLTB) is a common form of extrapulmonary tuberculosis. It often resolves without chemotherapy being hence considered a rather…”
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Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
Published in Annals of the New York Academy of Sciences (01-07-2012)“…We evaluated immune and endocrine status following antituberculosis treatment in HIV‐negative patients with newly diagnosed tuberculosis (TB). Treatment led to…”
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Oxidative stress in ventral prostate, ovary, and breast by 2,4-dichlorophenoxyacetic acid in pre- and postnatal exposed rats
Published in Environmental toxicology (01-01-2013)“…The herbicide 2,4‐dichlorophenoxyacetic acid (2,4‐D) has been widely used in agriculture and forestry since the 1940s. 2,4‐D has been shown to produce a wide…”
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DHEA induces autophagy in THP1-derived macrophages infected with Mycobacterium tuberculosis
Published in Frontiers in immunology (2015)“…Abstract only…”
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TGF-β neutralization abrogates the inhibited DHEA production mediated by factors released from M. tuberculosis-stimulated PBMC
Published in Annals of the New York Academy of Sciences (01-07-2012)“…Supernatants (SN) from cultures of peripheral blood mononuclear cells (PBMC) of tuberculosis (TB) patients inhibit dehydroepiandrosterone (DHEA) secretion by…”
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Levels of inflammatory cytokines, adrenal steroids, and mRNA for GRα, GRβ and 11βHSD1 in TB pleurisy
Published in Tuberculosis (Edinburgh, Scotland) (01-11-2013)“…Summary Our previous work on the immune-endocrine features of patients with pulmonary tuberculosis (TB) showed markedly decreased plasma levels of…”
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TGF-[beta] neutralization abrogates the inhibited DHEA production mediated by factors released from M. tuberculosis-stimulated PBMC
Published in Annals of the New York Academy of Sciences (01-07-2012)“…Supernatants (SN) from cultures of peripheral blood mononuclear cells (PBMC) of tuberculosis (TB) patients inhibit dehydroepiandrosterone (DHEA) secretion by…”
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An analysis of the immune-endocrine changes occurring in tuberculosis patients from the time of disease diagnosis to treatment completion and clinical recovery
Published in Frontiers in immunology (2015)“…Abstract only…”
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