Search Results - "Betterman, Kelly L"

The lymphatic vasculature: development and role in shaping immunity by Betterman, Kelly L., Harvey, Natasha L.

“…Summary The lymphatic vasculature is an integral component of the immune system. Lymphatic vessels are a key highway via which immune cells are trafficked,…”
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Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow by Betterman, Kelly L, Sutton, Drew L, Secker, Genevieve A, Kazenwadel, Jan, Oszmiana, Anna, Lim, Lillian, Miura, Naoyuki, Sorokin, Lydia, Hogan, Benjamin M, Kahn, Mark L, McNeill, Helen, Harvey, Natasha L

“…The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The…”
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Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature by Koltowska, Katarzyna, Betterman, Kelly L, Harvey, Natasha L, Hogan, Benjamin M

“…The lymphatic vascular system develops from the pre-existing blood vasculature of the vertebrate embryo. New insights into lymphatic vascular development have…”
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GATA2 is required for lymphatic vessel valve development and maintenance by Kazenwadel, Jan, Betterman, Kelly L, Chong, Chan-Eng, Stokes, Philippa H, Lee, Young K, Secker, Genevieve A, Agalarov, Yan, Demir, Cansaran Saygili, Lawrence, David M, Sutton, Drew L, Tabruyn, Sebastien P, Miura, Naoyuki, Salminen, Marjo, Petrova, Tatiana V, Matthews, Jacqueline M, Hahn, Christopher N, Scott, Hamish S, Harvey, Natasha L

“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
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A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development by Pichol-Thievend, Cathy, Betterman, Kelly L, Liu, Xiaolei, Ma, Wanshu, Skoczylas, Renae, Lesieur, Emmanuelle, Bos, Frank L, Schulte, Dorte, Schulte-Merker, Stefan, Hogan, Benjamin M, Oliver, Guillermo, Harvey, Natasha L, Francois, Mathias

“…Despite the essential role of the lymphatic vasculature in tissue homeostasis and disease, knowledge of the organ-specific origins of lymphatic endothelial…”
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Decoys and Cardiovascular Development: CXCR7 and Regulation of Adrenomedullin Signaling by Betterman, Kelly L., Harvey, Natasha L.

“…Decoy receptors have ligand binding capacity but, in contrast to cognate receptors, do not initiate typical downstream signaling cascades. In this issue of…”
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In vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGFR1 signalling in lymphangiogenesis by Kazenwadel, Jan, Secker, Genevieve A, Betterman, Kelly L, Harvey, Natasha L

“…Despite the importance of blood vessels and lymphatic vessels during development and disease, the signalling pathways underpinning vessel construction remain…”
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Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development by Kartopawiro, Joëlle, Bower, Neil I, Karnezis, Tara, Kazenwadel, Jan, Betterman, Kelly L, Lesieur, Emmanuelle, Koltowska, Katarzyna, Astin, Jonathan, Crosier, Philip, Vermeren, Sonja, Achen, Marc G, Stacker, Steven A, Smith, Kelly A, Harvey, Natasha L, François, Mathias, Hogan, Benjamin M

“…Mutations in SOX18, VEGFC and Vascular Endothelial Growth Factor 3 underlie the hereditary lymphatic disorders hypotrichosis-lymphedema-telangiectasia (HLT),…”
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Histological and Morphological Characterization of Developing Dermal Lymphatic Vessels by Betterman, Kelly L, Harvey, Natasha L

“…The capacity to visualize the lymphatic vasculature in three-dimensions has revolutionized our understanding of the morphogenetic mechanisms important for…”
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Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival by Debrincat, Marlyse A., Josefsson, Emma C., James, Chloé, Henley, Katya J., Ellis, Sarah, Lebois, Marion, Betterman, Kelly L., Lane, Rachael M., Rogers, Kelly L., White, Michael J., Roberts, Andrew W., Harvey, Natasha L., Metcalf, Donald, Kile, Benjamin T.

“…Mature megakaryocytes depend on the function of Bcl-xL, a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of platelet…”
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A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis by Ebert, Lisa M., Tan, Lih Y., Johan, M. Zahied, Min, Kay Khine Myo, Cockshell, Michaelia P., Parham, Kate A., Betterman, Kelly L., Szeto, Paceman, Boyle, Samantha, Silva, Lokugan, Peng, Angela, Zhang, YouFang, Ruszkiewicz, Andrew, Zannettino, Andrew C. W., Gronthos, Stan, Koblar, Simon, Harvey, Natasha L., Lopez, Angel F., Shackleton, Mark, Bonder, Claudine S.

“…Desmogleins (DSG) are a family of cadherin adhesion proteins that were first identified in desmosomes and provide cardiomyocytes and epithelial cells with the…”
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Remodeling of the Lymphatic Vasculature during Mouse Mammary Gland Morphogenesis Is Mediated via Epithelial-Derived Lymphangiogenic Stimuli by Betterman, Kelly L, Paquet-Fifield, Sophie, Asselin-Labat, Marie-Liesse, Visvader, Jane E, Butler, Lisa M, Stacker, Steven A, Achen, Marc G, Harvey, Natasha L

“…Despite the key roles of lymphatic vessels in homeostasis and disease, the cellular sources of signals that direct lymphatic vascular growth and patterning…”
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Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow by Betterman, Kelly L, Sutton, Drew L, Secker, Genevieve A, Kazenwadel, Jan, Oszmiana, Anna, Lim, Lillian, Miura, Naoyuki, Sorokin, Lydia, Hogan, Benjamin M, Kahn, Mark L, McNeill, Helen, Harvey, Natasha L

“…The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The…”
Get full text

GATA2 is required for lymphatic vessel valve development and maintenance by Kazenwadel, Jan, Betterman, Kelly L, Chong, Chan-Eng, Stokes, Philippa H, Lee, Young K, Secker, Genevieve A, Agalarov, Yan, Demir, Cansaran Saygili, Lawrence, David M, Sutton, Drew L, Tabruyn, Sebastien P, Miura, Naoyuki, Salminen, Marjo, Petrova, Tatiana V, Matthews, Jacqueline M, Hahn, Christopher N, Scott, Hamish S, Harvey, Natasha L

“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
Get full text

Mcl-1 and Bel-xL coordinately regulate megakaryocyte survival by DEBRINCAT, Marlyse A, JOSEFSSON, Emma C, ROBERTS, Andrew W, HARVEY, Natasha L, METCALF, Donald, KILE, Benjamin T, JAMES, Chloé, HENLEY, Katya J, ELLIS, Sarah, LEBOIS, Marion, BETTERMAN, Kelly L, LANE, Rachael M, ROGERS, Kelly L, WHITE, Michael J

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Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival by Debrincat, Marlyse A, Josefsson, Emma C, James, Chloé, Henley, Katya J, Ellis, Sarah, Lebois, Marion, Betterman, Kelly L, Lane, Rachael M, Rogers, Kelly L, White, Michael J, Roberts, Andrew W, Harvey, Natasha L, Metcalf, Donald, Kile, Benjamin T

“…Mature megakaryocytes depend on the function of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of…”
Get full text