Search Results - "Bett, John S"

Proteostasis regulation by the ubiquitin system by Bett, John S

“…Cells have developed an evolutionary obligation to survey and maintain proteome fidelity and avoid the possible toxic consequences of protein misfolding and…”
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UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome by Hjerpe, Roland, Bett, John S., Keuss, Matthew J., Solovyova, Alexandra, McWilliams, Thomas G., Johnson, Clare, Sahu, Indrajit, Varghese, Joby, Wood, Nicola, Wightman, Melanie, Osborne, Georgina, Bates, Gillian P., Glickman, Michael H., Trost, Matthias, Knebel, Axel, Marchesi, Francesco, Kurz, Thimo

“…Clearance of misfolded and aggregated proteins is central to cell survival. Here, we describe a new pathway for maintaining protein homeostasis mediated by the…”
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Suppression of protein aggregation by chaperone modification of high molecular weight complexes by LABBADIA, John, NOVOSELOV, Sergey S, BETT, John S, WEISS, Andreas, PAGANETTI, Paolo, BATES, Gillian P, CHEETHAM, Michael E

“…Protein misfolding and aggregation are associated with many neurodegenerative diseases, including Huntington's disease. The cellular machinery for maintaining…”
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The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability by Bett, John S, Ibrahim, Adel F M, Garg, Amit K, Kelly, Van, Pedrioli, Patrick, Rocha, Sonia, Hay, Ronald T

“…HIF1A (hypoxia-inducible factor 1α) is the master regulator of the cellular response to hypoxia and is implicated in cancer progression. Whereas the regulation…”
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Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers by Bett, John S, Ritorto, Maria Stella, Ewan, Richard, Jaffray, Ellis G, Virdee, Satpal, Chin, Jason W, Knebel, Axel, Kurz, Thimo, Trost, Matthias, Tatham, Michael H, Hay, Ronald T

“…Modification of proteins with ubiquitin (Ub) occurs through a variety of topologically distinct Ub linkages, including Ube2W-mediated monoubiquitylation of…”
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The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease by Bett, John S, Cook, Casey, Petrucelli, Leonard, Bates, Gillian P

“…Impairment of the ubiquitin-proteasome system (UPS) has long been considered an attractive hypothesis to explain the selective dysfunction and death of neurons…”
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The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathway by Bett, John S, Kanuga, Naheed, Richet, Emma, Schmidtke, Gunter, Groettrup, Marcus, Cheetham, Michael E, van der Spuy, Jacqueline

“…Mutations in AIPL1 cause the inherited blindness Leber congenital amaurosis (LCA). AIPL1 has previously been shown to interact with NUB1, which facilitates the…”
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Molecular chaperones and photoreceptor function by Kosmaoglou, Maria, Schwarz, Nele, Bett, John S., Cheetham, Michael E.

“…Molecular chaperones facilitate and regulate protein conformational change within cells. This encompasses many fundamental cellular processes: including the…”
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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGγ as a therapeutic target by Bett, John S., Goellner, Geoffrey M., Woodman, Ben, Pratt, Gregory, Rechsteiner, Martin, Bates, Gillian P.

“…Huntington's disease (HD) is one of a group of neurodegenerative disorders caused by the pathological expansion of a glutamine tract. A hallmark of these…”
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The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease by Bett, John S., Benn, Caroline L., Ryu, Kwon‐Yul, Kopito, Ron R., Bates, Gillian P.

“…Huntington's disease (HD) is an inherited neurodegenerative disease caused by the expansion of a polyglutamine tract in the protein huntingtin (htt). HD brains…”
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SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells by Bett, John S, Ibrahim, Adel F M, Garg, Amit K, Rocha, Sonia, Hay, Ronald T

“…Post-translational modification of proteins with ubiquitin and ubiquitin-like molecules (UBLs) is emerging as a dynamic cellular signaling network that…”
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siRNA Screening to Identify Ubiquitin and Ubiquitin-like System Regulators of Biological Pathways in Cultured Mammalian Cells by Bett, John S., Ibrahim, Adel F. M., Garg, Amit K., Rocha, Sonia, Hay, Ronald T.

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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REG[gamma] as a therapeutic target by Bett, John S, Goellner, Geoffrey M, Woodman, Ben, Pratt, Gregory, Rechsteiner, Martin, Bates, Gillian P

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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target by Bett, John S, Goellner, Geoffrey M, Woodman, Ben, Pratt, Gregory, Rechsteiner, Martin, Bates, Gillian P

“…Huntington's disease (HD) is one of a group of neurodegenerative disorders caused by the pathological expansion of a glutamine tract. A hallmark of these…”
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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REG[gamma] as a therapeutic target by Bett, John S, Goellner, Geoffrey M, Woodman, Ben, Pratt, Gregory, Rechsteiner, Martin, Bates, Gillian P

“…Huntington's disease (HD) is one of a group of neurodegenerative disorders caused by the pathological expansion of a glutamine tract. A hallmark of these…”
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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGγ as a therapeutic target by Bett, John S., Goellner, Geoffrey M., Woodman, Ben, Pratt, Gregory, Rechsteiner, Martin, Bates, Gillian P.

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Hydrogen held by solids. XII. Hydroxyapatite catalysts by Bett, John A. S, Christner, Larry G, Hall, W. Keith

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The Kinetics of the Isomerization of the Tetramethylbenzenes in Anhydrous Hydrofluoric Acid by Kilpatrick, Martin, Bett, John A. S, Kilpatrick, Mary L

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