Search Results - "Bethke, Frederic"

Targeting atypical protein kinase C iota reduces viability in glioblastoma stem‐like cells via a notch signaling mechanism by Phillips, Emma, Lang, Verena, Bohlen, Jonathan, Bethke, Frederic, Puccio, Laura, Tichy, Diana, Herold‐Mende, Christel, Hielscher, Thomas, Lichter, Peter, Goidts, Violaine

“…In a previous study, Protein Kinase C iota (PRKCI) emerged as an important candidate gene for glioblastoma (GBM) stem‐like cell (GSC) survival. Here, we show…”
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PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma by Phillips, Emma, Balss, Jörg, Bethke, Frederic, Pusch, Stefan, Christen, Stefan, Hielscher, Thomas, Schnölzer, Martina, Fletcher, Michael N. C., Habel, Antje, Tessmer, Claudia, Brenner, Lisa-Marie, Göttmann, Mona, Capper, David, Herold-Mende, Christel, von Deimling, Andreas, Fendt, Sarah-Maria, Goidts, Violaine

“…Glioblastoma is a highly aggressive brain tumor for which there is no cure. The metabolic enzyme 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4)…”
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Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity by Lokumcu, Tolga, Iskar, Murat, Schneider, Martin, Helm, Dominic, Klinke, Glynis, Schlicker, Lisa, Bethke, Frederic, Müller, Gabriele, Richter, Karsten, Poschet, Gernot, Phillips, Emma, Goidts, Violaine

“…Glioblastoma is a deadly brain tumor for which there is no cure. The presence of glioblastoma stem-like cells (GSCs) contributes to the heterogeneous nature of…”
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Malformin C preferentially kills glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade by Phillips, Emma, van Enk, Sizèd, Kildgaard, Sara, Schlue, Silja, Göttmann, Mona, Jennings, Victoria, Bethke, Frederic, Müller, Gabriele, Herold-Mende, Christel, Pastor-Flores, Daniel, Schneider, Martin, Helm, Dominic, Ostenfeld Larsen, Thomas, Goidts, Violaine

“…Glioblastoma is a highly aggressive brain tumor for which there is no cure. The dire prognosis of this disease is largely attributable to a high level of…”
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Abstract 1906: PFKFB4 , much more than just a glycolytic gene by Phillips, Emma L., Bethke, Frederic, Balss, Jörg, Pusch, Stefan, Christen, Stefan, Schnölzer, Martina, Habel, Antje, Capper, David, Deimling, Andreas Von, Fendt, Sarah-Maria, Lichter, Peter, Goidts, Violaine

“…Abstract Glioblastoma is one of the most aggressive primary brain tumors in adults, with a dismal median overall survival of only 14 months after diagnosis…”
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Abstract 655: Fungal extract screening reveals malformin C to preferentially kill glioblastoma stem-like cells via concerted induction of proteotoxic stress and autophagic flux blockade by Phillips, Emma L., van Enk, Sizèd, Kildgaard, Sara, Schlue, Silja, Göttmann, Mona, Jennings, Victoria, Bethke, Frederic, Müller, Gabriele, Herold-Mende, Christel, Pastor-Flores, Daniel, Schneider, Martin, Helm, Dominic, Larsen, Thomas Ostenfeld, Goidts, Violaine

“…Abstract Glioblastoma is a highly aggressive brain tumor for which there is no cure. The dire prognosis of this disease is largely attributable to a high level…”
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