Search Results - "Bethea, C L"

Relationships between androgens, serotonin gene expression and innervation in male macaques by Bethea, C.L, Coleman, K, Phu, K, Reddy, A.P, Phu, A

“…Highlights • Androgens increase TPH2 and SERT gene expression in male monkeys. • Aromatase inhibition prevents serotonin transport through axons. • Estrogen…”
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Ovarian Regulation of Kisspeptin Neurones in the Arcuate Nucleus of the Rhesus Monkey (Macaca mulatta) by Alçin, E., Sahu, A., Ramaswamy, S., Hutz, E. D., Keen, K. L., Terasawa, E., Bethea, C. L., Plant, T. M.

“…Tonic gonadotrophin secretion throughout the menstrual cycle is regulated by the negative‐feedback actions of ovarian oestradiol (E2) and progesterone…”
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Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques by Bethea, C.L, Smith, A.W, Centeno, M.L, Reddy, A.P

“…Abstract The serotonin system responds to the ovarian steroids, estradiol (E) and progesterone (P), in women and female animal models. In macaques, ovarian…”
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Androgen metabolites impact CSF amines and axonal serotonin via MAO-A and -B in male macaques by Bethea, C.L, Phu, K, Kim, A, Reddy, A.P

“…Highlights • MAO-A expression was suppressed by metabolism of T to E. • MAO-B expression was increased by T and DHT. • Aromatase was not regulated by T or its…”
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Ovarian steroid regulation of the midbrain corticotropin releasing factor and urocortin systems in macaques by Sanchez, R.L, Reddy, A.P, Bethea, C.L

“…Abstract A significant number of postmenopausal women report increased anxiety and vulnerability to stress, which has been linked to decreased secretion of…”
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Ovarian steroids increase spinogenetic proteins in the macaque dorsal raphe by Rivera, H.M, Bethea, C.L

“…Abstract Dendritic spines are the basic structural units of neuronal plasticity. Intracellular signaling cascades that promote spinogenesis have centered on…”
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Differential effects of ovarian steroids and raloxifene on serotonin 1A and 2C receptor protein expression in macaques by Henderson, J. A., Bethea, C. L.

“…To further understand the role of ovarian hormones in the function of the serotonin neural system, we investigated the effects of estradiol (E), progesterone…”
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Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques by LU, N. Z, ESHLEMAN, A. J, JANOWSKY, A, BETHEA, C. L

“…The serotonin reuptake transporter (SERT) plays an important role in serotonin neurotransmission and in several psychopathological disorders such as depression…”
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Ovarian steroid regulation of serotonin-1A autoreceptor messenger rna expression in the dorsal raphe of rhesus macaques by Pecins-Thompson, M., Bethea, C.L.

“…It is widely hypothesized that ovarian steroids act on serotonin neurons to modulate mood and alter neuroendocrine function in women. However, information is…”
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Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram by Lima, F.B, Centeno, M.L, Costa, M.E, Reddy, A.P, Cameron, J.L, Bethea, C.L

“…Abstract Female cynomolgus monkeys exhibit different degrees of reproductive dysfunction with moderate metabolic and psychosocial stress. When stressed with a…”
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Hypothalamic KISS1 Expression, Gonadotrophin-Releasing Hormone and Neurotransmitter Innervation Vary with Stress and Sensitivity in Macaques by Bethea, C. L., Kim, A., Reddy, A. P., Chin, A., Bethea, S. C., Cameron, J. L.

“…The present study examined the effect of short‐term psychosocial and metabolic stress in a monkey model of stress‐induced amenorrhaea on the…”
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Neuroprotective actions of ovarian hormones without insult in the raphe region of rhesus macaques by Tokuyama, Y, Reddy, A.P, Bethea, C.L

“…Abstract Using a nonhuman primate model of surgical menopause, our laboratory has shown that ovarian hormone treatment (HT) improves 5-HT neural function in…”
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5-HTTLPR genotype and gender, but not chronic fluoxetine administration, are associated with cortical TREK1 protein expression in rhesus macaques by Bogdan, R., Fitzgibbon, H., Woolverton, W.L., Bethea, C.L., Iyo, A.H., Stockmeier, C.A., Kyle, P.B., Austin, M.C.

“…► rh5-HTTLPR short allele carriers had reduced cortical TREK1 protein expression. ► Female monkeys had reduced cortical TREK1 protein expression. ► Chronic…”
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Hypothalamic Gonadotrophin-Releasing Hormone Expression in Female Monkeys with Different Sensitivity to Stress by Centeno, M.-L., Sanchez, R. L., Cameron, J. L., Bethea, C. L.

“…Psychosocial stress, combined with mild dieting and moderate exercise, are observed in women seeking treatment for hypothalamic amenorrhea. Using female…”
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Unique responses of midbrain CART neurons in macaques to ovarian steroids by Lima, F.B, Henderson, J.A, Reddy, A.P, Tokuyama, Y, Hubert, G.W, Kuhar, M.J, Bethea, C.L

“…Abstract CART (cocaine and amphetamine regulated transcript) is a neuropeptide involved in the control of several physiological processes, such as response to…”
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Ovarian steroids and serotonin neural function by Bethea, C L, Pecins-Thompson, M, Schutzer, W E, Gundlah, C, Lu, Z N

“…The serotonin neural system originates from ten nuclei in the mid- and hindbrain regions. The cells of the rostral nuclei project to almost every area of the…”
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Serotonin-related gene expression in female monkeys with individual sensitivity to stress by Bethea, C.L., Streicher, J.M., Mirkes, S.J., Sanchez, R.L., Reddy, A.P., Cameron, J.L.

“…Female cynomolgus monkeys exhibit different degrees of reproductive dysfunction with moderate metabolic and psychosocial stress. In this study, the expression…”
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Ovarian hormone influences on the density of immunoreactivity for tyrosine hydroxylase and serotonin in the primate corpus striatum by Kritzer, M.F, Adler, A, Bethea, C.L

“…The serotonergic and dopaminergic inputs to the corpus striatum in human and non-human primates participate in diverse sensorimotor, cognitive, and affective…”
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Steroid regulation of tryptophan hydroxylase protein in the dorsal raphe of macaques by Bethea, Cynthia L, Mirkes, Stephanie J, Shively, Carol A, Adams, Michael R

“…Background: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme for the synthesis of serotonin, and serotonin is a pivotal neurotransmitter in the…”
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Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques by Bethea, C L, Reddy, A P

“…Depression often accompanies the perimenopausal transition and it often precedes overt symptomology in common neurodegenerative diseases (NDDs, such as…”
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