Search Results - "Besztercei, Balazs"
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Sigma-1 Receptor Agonist Fluvoxamine Ameliorates Fibrotic Response of Trabecular Meshwork Cells
Published in International journal of molecular sciences (01-07-2023)“…Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor…”
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Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control
Published in Nucleic acids research (29-10-2014)“…Transfer of phage-related pathogenicity islands of Staphylococcus aureus (SaPI-s) was recently reported to be activated by helper phage dUTPases. This is a…”
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Sigma-1 Receptor Activation Is Protective against TGFβ2-Induced Extracellular Matrix Changes in Human Trabecular Meshwork Cells
Published in Life (Basel, Switzerland) (01-07-2023)“…The trabecular meshwork (TM) route is the principal outflow egress of the aqueous humor. Actin cytoskeletal remodeling in the TM and extracellular matrix (ECM)…”
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Subcellular Localization of Thioredoxin/Thioredoxin Reductase System-A Missing Link in Endoplasmic Reticulum Redox Balance
Published in International journal of molecular sciences (01-06-2024)“…The lumen of the endoplasmic reticulum (ER) is usually considered an oxidative environment; however, oxidized thiol-disulfides and reduced pyridine nucleotides…”
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LPA-Induced Thromboxane A2-Mediated Vasoconstriction Is Limited to Poly-Unsaturated Molecular Species in Mouse Aortas
Published in International journal of molecular sciences (01-07-2024)“…We have previously reported that, in aortic rings, 18:1 lysophosphatidic acid (LPA) can induce both vasodilation and vasoconstriction depending on the…”
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6
Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model
Published in Scientific reports (08-04-2024)“…Female breast cancer is the most diagnosed cancer worldwide. Triple negative breast cancer (TNBC) is the most aggressive type and there is no existing…”
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Stress-Induced, p53-Mediated Tumor Growth Inhibition of Melanoma by Modulated Electrohyperthermia in Mouse Models without Major Immunogenic Effects
Published in International journal of molecular sciences (17-08-2019)“…Modulated electrohyperthermia (mEHT), an innovative complementary technique of radio-, chemo-, and targeted oncotherapy modalities, can induce tumor apoptosis…”
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Digoxin-Mediated Inhibition of Potential Hypoxia-Related Angiogenic Repair in Modulated Electro-Hyperthermia (mEHT)-Treated Murine Triple-Negative Breast Cancer Model
Published in ACS pharmacology & translational science (09-02-2024)“…Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer type with no targeted therapy and hence limited treatment options. Modulated…”
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The SH3 domain of Caskin1 binds to lysophosphatidic acid suggesting a direct role for the lipid in intracellular signaling
Published in Cellular signalling (01-04-2017)“…Src homology 3 or SH3 domains constitute one of the most common protein domains in signal transduction, generally characterized by their binding to…”
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Characterization of Native and Human Serum Albumin-Bound Lysophosphatidic Acid Species and Their Effect on the Viability of Mesenchymal Stem Cells In Vitro
Published in Applied sciences (01-08-2022)“…Scaffolds can provide a healthy environment for cell attachment, differentiation, proliferation, and migration in vitro and in vivo. Lysophosphatidic acid…”
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Correction to “Digoxin-Mediated Inhibition of Potential Hypoxia-Related Angiogenic Repair in Modulated Electro-Hyperthermia (mEHT)-Treated Murine Triple-Negative Breast Cancer Model”
Published in ACS pharmacology & translational science (08-03-2024)“…[This corrects the article DOI: 10.1021/acsptsci.3c00296.]…”
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Angiotensin II-Induced Cardiac Effects Are Modulated by Endocannabinoid-Mediated CB1 Receptor Activation
Published in Cells (Basel, Switzerland) (24-03-2021)“…Angiotensin II (Ang II) has various cardiac effects and causes vasoconstriction. Ang II activates the type-1 angiotensin receptor—Gq/11 signaling pathway…”
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Sigma‐1 receptor agonist ameliorates trabecular meshwork fibrosis by modulating extracellular matrix remodelling and increasing nitric oxide production
Published in Acta ophthalmologica (Oxford, England) (01-01-2024)“…Purpose: Maintenance of normal tissue homeostasis in the trabecular meshwork (TM) is crucial for unaltered intraocular pressure (IOP). Fibrotic‐like disorder…”
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Reduced O -GlcNAcylation and tubular hypoxia contribute to the antifibrotic effect of SGLT2 inhibitor dapagliflozin in the diabetic kidney
Published in American journal of physiology. Renal physiology (01-04-2020)“…Diabetic kidney disease is a worldwide epidemic, and therapies are incomplete. Clinical data suggest that improved renal outcomes by Na -glucose cotransporter…”
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Fluvoxamine supresses transforming growth factor beta‐2‐induced fibrotic changes in trabecular meshwork cells
Published in Acta ophthalmologica (Oxford, England) (01-01-2024)“…Aims/Purpose: Primary open‐angle glaucoma is the leading cause of blindness worldwide, but no definitive treatment is available. Fibrotic‐like changes of…”
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Sigma − 1 receptor activation as a new option for the treatment of glaucoma in preclinical models
Published in Acta ophthalmologica (Oxford, England) (01-12-2022)“…Introduction: Trabecular meshwork (TM) is the main pathway for aqueous humour drainage. The fibrotic‐like remodelling of the actin cytoskeleton in TM cells…”
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The role of thioredoxin / thioredoxin reductase system in the redox homeostasis of the endoplasmic reticulum
Published in Free radical biology & medicine (01-12-2021)Get full text
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Abstract 196: The effect of modulated electro-hyperthermia on B16-F10 melanoma tumor growth
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract The objective of the present study was to examine the effect of modulated electro-hyperthermia (mEHT) on B16-F10 mouse melanoma cell line in vitro and…”
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Angiotensin II-Induced Cardiac Effects Are Modulated by Endocannabinoid-Mediated CB 1 Receptor Activation
Published in Cells (Basel, Switzerland) (24-03-2021)“…Angiotensin II (Ang II) has various cardiac effects and causes vasoconstriction. Ang II activates the type-1 angiotensin receptor-G signaling pathway resulting…”
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20
Preclinical and clinical investigation and development of electromagnetic oncological device - experience with solid tumors
Published in Magyar onkologia (09-12-2019)“…Our objective was to develop an electromagnetic tumor therapy device in a consortial cooperation between Semmelweis University and Oncotherm Ltd., to provide…”
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