Search Results - "Besterman, J"

Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens by Pfaller, M.A, Messer, S.A, Georgopapadakou, N, Martell, L.A, Besterman, J.M, Diekema, D.J

“…We report on the in vitro activity of the Hos2 fungal histone deacetylase (HDAC) inhibitor MGCD290 (MethylGene, Inc.) in combination with azoles against…”
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A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly by Stewart, D. J., Donehower, R. C., Eisenhauer, E. A., Wainman, N., Shah, A. K., Bonfils, C., MacLeod, A. R., Besterman, J. M., Reid, G. K.

“…Background: Hypermethylation and inactivation of tumor suppressor genes by the enzyme DNA methyltransferase may lead to neoplastic transformation. MG98, a…”
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Models of Human Metastatic Colon Cancer in Nude Mice Orthotopically Constructed by Using Histologically Intact Patient Specimens by Fu, Xinyu, Besterman, Jeffrey M., Monosov, Ann, Hoffman, Robert M.

“…There is an important need for clinically relevant animal models for human cancers. Toward this goal, histologically intact human colon-cancer specimens…”
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Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors : demonstration of tumor-type specificity and implications for cancer chemotherapy by INTISAR HUSAIN, MOHLER, J. L, SEIGLER, H. F, BESTERMAN, J. M

“…Topoisomerase I has been identified as an intracellular target of camptothecin, a plant alkaloid with anticancer activity. Various lines of evidence suggest…”
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Rapid Formation of Diacylglycerol from Phosphatidylcholine: A Pathway for Generation of a Second Messenger by Besterman, Jeffrey M., Duronio, Vincent, Cuatrecasas, Pedro

“…The classic pathway for agonist-induced generation of diacylglycerol is via activation of a phospholipase C-mediated hydrolysis of the ``phosphoinositides.''…”
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Computerization of the Yale insulin infusion protocol and potential insights into causes of hypoglycemia with intravenous insulin by Marvin, Michael R, Inzucchi, Silvio E, Besterman, Brian J

“…The management of critically ill hyperglycemic patients in the intensive care unit (ICU) has been fraught with recent controversy. Only one randomized trial…”
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Minimization of Hypoglycemia as an Adverse Event During Insulin Infusion: Further Refinement of the Yale Protocol by Marvin, Michael R, Inzucchi, Silvio E, Besterman, Brian J

“…The management of hyperglycemia in the intensive care unit has been a controversial topic for more than a decade, with target ranges varying from 80-110 mg/dL…”
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Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I by Luzzio, Michael J, Besterman, Jeffrey M, Emerson, David L, Evans, Michael G, Lackey, Karen, Leitner, Peter L, McIntyre, Gordon, Morton, Bradley, Myers, Peter L, Peel, Michael, Sisco, Jay M, Sternbach, Daniel D, Tong, Wei-Qin, Truesdale, Ann, Uehling, David E, Vuong, Alan, Yates, Julie

“…The synthesis and antitumor activities of the novel water soluble camptothecin derivatives 7-[(4-methylpiperazino)methyl]-10,11-(methylenedioxy)-(20S)-campto…”
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Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms by Fournel, M, Sapieha, P, Beaulieu, N, Besterman, J M, MacLeod, A R

“…A common event in the development of human neoplasia is the loss of growth regulatory tumor suppressor functions. Methylation of 5' CpG islands of tumor…”
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Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination by Chen, Jingwen, Tomkinson, Alan E., Ramos, William, Mackey, Zachary B., Danehower, Sue, Walter, Christi A., Schultz, Roger A., Besterman, Jeffrey M., Husain, Intisar

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors by FOURNEL, Marielle, TRACHY-BOURGET, Marie-Claude, DELORME, Daniel, MACLEOD, A. Robert, BESTERMAN, Jeffrey M, ZUOMEI LI, YAN, P. Theresa, KALITA, Ann, BONFILS, Claire, BEAULIEU, Carole, FRECHETTE, Sylvie, LEIT, Silvana, ABOU-KHALIL, Elie, WOO, Soon-Hyung

“…Inhibition of histone deacetylases (HDACs) is emerging as a new strategy in human cancer therapy. We have designed and synthesized novel nonhydroxamate…”
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395 MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor, in combination with erlotinib: clinical and preclinical experience by Patnaik, A, Besterman, J, Tolcher, A.W, Mehran, M, Drouin, M, Maroun, C, Bonfils, C, Beeram, M, Martell, R, Papadopoulos, K

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396 MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor, in combination with docetaxel: clinical and preclinical experience by O'Dwyer, P, Papadopoulos, K, Amaravadi, R, Harlacker, K, Beeram, M, Drouin, M, Mehran, M, Besterman, J, Maroun, C, Patnaik, A

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Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange by J M Besterman, W S May, Jr, H LeVine, 3rd, E J Cragoe, Jr, P Cuatrecasas

“…The human leukemic cell line, HL-60, differentiates in response to tumor-promoting phorbol esters. Recently, we have reported that one of the first events…”
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Collagen cross-link metabolites in urine as markers of bone metastases in prostatic carcinoma by Miyamoto, K K, McSherry, S A, Robins, S P, Besterman, J M, Mohler, J L

“…The efficacy of radionuclide bone scans in monitoring metastatic bone activity remains controversial. Objective measurement of bone tumor burden would be…”
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Phorbol Esters Rapidly Stimulate Amiloride-Sensitive Na+/ H+ Exchange in a Human Leukemic Cell Line by Besterman, Jeffrey M., Cuatrecasas, Pedro

“…The human, leukemic cell line, HL-60, undergoes differentiation in response to tumor-promoting phorbol esters. Recent studies have implicated stimulation of a…”
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In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues by EMERSON, D. L, BESTERMAN, J. M, BROWN, H. R, EVANS, M. G, LEITNER, P. P, LUZZIO, M. J, SHAFFER, J. E, STERNBACH, D. D, UEHLING, D, VUONG, A

“…The development of camptothecin-like compounds as inhibitors of topoisomerase I for the treatment of resistant tumors has generated clinical excitement in this…”
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Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation by Wang, Y.C., Burkhart, W.A., Mackey, Z.B., Moyer, M.B., Ramos, W, Husain, I, Chen, J, Besterman, J.M., Tomkinson, A.E.

“…Mammalian cells contain three biochemically distinct DNA ligases. In this report we describe the purification of DNA ligase II to homogeneity from bovine liver…”
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Protein Kinase C Phosphorylates Topoisomerase II: Topoisomerase Activation and Its Possible Role in Phorbol Ester-Induced Differentiation of HL-60 Cells by Sahyoun, Naji, Wolf, Marlene, Besterman, Jeffrey, Hsieh, Tao-Shih, Sander, Miriam, LeVine, Harry, Chang, Kwen-Jen, Cuatrecasas, Pedro

“…DNA topoisomerase II from Drosophila was phosphorylated effectively by protein kinase C. With a Km of about 100 nM, the reaction was rapid, occurring at 4…”
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Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands. Kinetics and specificity by GEORGE, J. W, GHATE, S, MATSON, S. W, BESTERMAN, J. M

“…Although DNA helicases play important roles in the processing of DNA, little is known about the effects of DNA-interacting ligands on these helicases…”
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