Search Results - "Bester, Romina"

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels by Ko, Chunkyu, Chakraborty, Anindita, Chou, Wen-Min, Hasreiter, Julia, Wettengel, Jochen M., Stadler, Daniela, Bester, Romina, Asen, Theresa, Zhang, Ke, Wisskirchen, Karin, McKeating, Jane A., Ryu, Wang-Shick, Protzer, Ulrike

“…[Display omitted] •Studying HBV has been limited by the availability of in vitro and in vivo models.•A selected HepG2 cell clone expressing NTCP supports…”
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A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection by Ko, Chunkyu, Bester, Romina, Zhou, Xue, Xu, Zhiheng, Blossey, Christoph, Sacherl, Julia, Vondran, Florian W R, Gao, Lu, Protzer, Ulrike

“…Hepatitis B virus (HBV) is a major human pathogen, killing an estimated 887,000 people per year. Therefore, potentially curative therapies are of high…”
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Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20 by Stadler, Daniela, Kächele, Martin, Jones, Alisha N, Hess, Julia, Urban, Christian, Schneider, Jessica, Xia, Yuchen, Oswald, Andreas, Nebioglu, Firat, Bester, Romina, Lasitschka, Felix, Ringelhan, Marc, Ko, Chunkyu, Chou, Wen-Min, Geerlof, Arie, van de Klundert, Maarten A, Wettengel, Jochen M, Schirmacher, Peter, Heikenwälder, Mathias, Schreiner, Sabrina, Bartenschlager, Ralf, Pichlmair, Andreas, Sattler, Michael, Unger, Kristian, Protzer, Ulrike

“…Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available…”
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Prion strains depend on different endocytic routes for productive infection by Fehlinger, Andrea, Wolf, Hanna, Hossinger, André, Duernberger, Yvonne, Pleschka, Catharina, Riemschoss, Katrin, Liu, Shu, Bester, Romina, Paulsen, Lydia, Priola, Suzette A., Groschup, Martin H., Schätzl, Hermann M., Vorberg, Ina M.

“…Prions are unconventional agents composed of misfolded prion protein that cause fatal neurodegenerative diseases in mammals. Prion strains induce specific…”
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Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants by Svilenov, Hristo L., Bester, Romina, Sacherl, Julia, Absmeier, Ramona, Peters, Carsten, Protzer, Ulrike, Brockmeyer, Carsten, Buchner, Johannes

“…Coronavirus infections are a world-wide threat to human health. A promising strategy to develop a broadly active antiviral is the use of fusion proteins…”
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Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis by Nieborak, Anna, Lukauskas, Saulius, Capellades, Jordi, Heyn, Patricia, Santos, Gabriela Silva, Motzler, Karsten, Zeigerer, Anja, Bester, Romina, Protzer, Ulrike, Schelter, Florian, Wagner, Mirko, Carell, Thomas, Hruscha, Alexander, Schmid, Bettina, Yanes, Oscar, Schneider, Robert

“…Cancer cells convert more glucose into lactate than healthy cells, what contributes to their growth advantage. Pyruvate kinase (PK) is a key rate limiting…”
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Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR by Roffé, Martín, Beraldo, Flávio Henrique, Bester, Romina, Nunziante, Max, Bach, Christian, Mancini, Gabriel, Gilch, Sabine, Vorberg, Ina, Castilho, Beatriz A., Martins, Vilma Regina, Hajj, Glaucia Noeli Maroso, Weissmann, Charles

“…Transmissible spongiform encephalopathies are fatal neurodegenerative diseases caused by the conversion of prion protein (PrP C ) into an infectious isoform…”
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Improved SARS-CoV-2 Neutralization of Delta and Omicron BA.1 Variants of Concern after Fourth Vaccination in Hemodialysis Patients by Cheng, Cho-Chin, Platen, Louise, Christa, Catharina, Tellenbach, Myriam, Kappler, Verena, Bester, Romina, Liao, Bo-Hung, Holzmann-Littig, Christopher, Werz, Maia, Schönhals, Emely, Platen, Eva, Eggerer, Peter, Tréguer, Laëtitia, Küchle, Claudius, Schmaderer, Christoph, Heemann, Uwe, Renders, Lutz, Protzer, Ulrike, Braunisch, Matthias Christoph

“…Hemodialysis patients are exposed to a markedly increased risk when infected with SARS-CoV-2. To date, it is unclear if hemodialysis patients benefit from four…”
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SARS-CoV-2 Neutralization Capacity in Hemodialysis Patients with and without a Fifth Vaccination with the Updated Comirnaty Original/Omicron BA.4-5 Vaccine by Liao, Bo-Hung, Platen, Louise, Grommes, Myriam, Cheng, Cho-Chin, Holzmann-Littig, Christopher, Christa, Catharina, Haller, Bernhard, Kappler, Verena, Bester, Romina, Werz, Maia Lucia, Platen, Eva, Eggerer, Peter, Tréguer, Laëtitia, Küchle, Claudius, Schmaderer, Christoph, Heemann, Uwe, Renders, Lutz, Protzer, Ulrike, Braunisch, Matthias Christoph

“…Hemodialysis patients have reduced serologic immunity after SARS-CoV-2 vaccination compared to the general population and an increased risk of morbidity and…”
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Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors by Ko, Chunkyu, Su, Jinpeng, Festag, Julia, Bester, Romina, Kosinska, Anna D., Protzer, Ulrike

“…The mouse is not a natural host of hepatitis B virus (HBV) infection and - despite engraftment of hepatocytes with the HBV receptor - does not support…”
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Immunogenicity of a silica nanoparticle-based SARS-CoV-2 vaccine in mice by Barbey, Clara, Su, Jinpeng, Billmeier, Martina, Stefan, Nadine, Bester, Romina, Carnell, George, Temperton, Nigel, Heeney, Jonathan, Protzer, Ulrike, Breunig, Miriam, Wagner, Ralf, Peterhoff, David

“…[Display omitted] Safe and effective vaccines have been regarded early on as critical in combating the COVID-19 pandemic. Among the deployed vaccine platforms,…”
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SARS-CoV-2 productively infects human hepatocytes and induces cell death by Cheng, Cho-Chin, Ko, Chunkyu, Ambike, Shubhankar, Sacherl, Julia, Velkov, Stoyan, Liao, Bo-Hung, Bester, Romina, Gültan, Merve, Jakwerth, Constanze, Schmidt-Weber, Carsten, Bugert, Joachim, Wölfel, Roman, Grass, Vincent, Essbauer, Sandra, Keppler, Oliver, Mogler, Carolin, Vondran, Florian, Pichlmair, Andreas, Protzer, Ulrike

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THU-256 - SARS-CoV-2 productively infects human hepatocytes and induces cell death by Cheng, Cho-Chin, Ko, Chunkyu, Ambike, Shubhankar, Sacherl, Julia, Velkov, Stoyan, Liao, Bo-Hung, Bester, Romina, Gültan, Merve, Jakwerth, Constanze, Schmidt-Weber, Carsten, Bugert, Joachim, Wölfel, Roman, Grass, Vincent, Essbauer, Sandra, Keppler, Oliver, Mogler, Carolin, Vondran, Florian, Pichlmair, Andreas, Protzer, Ulrike

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Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance by Duernberger, Yvonne, Liu, Shu, Riemschoss, Katrin, Paulsen, Lydia, Bester, Romina, Kuhn, Peer-Hendrik, Schölling, Manuel, Lichtenthaler, Stefan F., Vorberg, Ina

“…Prions of lower eukaryotes are transmissible protein particles that propagate by converting homotypic soluble proteins into growing protein assemblies. Prion…”
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Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion by von Olshausen, Gesa, Quasdorff, Maria, Bester, Romina, Arzberger, Silke, Ko, Chunkyu, van de Klundert, Maarten, Zhang, Ke, Odenthal, Margarete, Ringelhan, Marc, Niessen, Carien M, Protzer, Ulrike

“…Hepatitis B virus (HBV) infection is a prominent cause of hepatocellular carcinoma (HCC) but the underlying molecular mechanisms are complex and multiple…”
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Globular Domain of the Prion Protein Needs to Be Unlocked by Domain Swapping to Support Prion Protein Conversion by Hafner-Bratkovič, Iva, Bester, Romina, Pristovšek, Primož, Gaedtke, Lars, Veranič, Peter, Gašperšič, Jernej, Manček-Keber, Mateja, Avbelj, Matevž, Polymenidou, Magdalini, Julius, Christian, Aguzzi, Adriano, Vorberg, Ina, Jerala, Roman

“…Prion diseases are fatal transmissible neurodegenerative diseases affecting many mammalian species. The normal prion protein (PrP) converts into a pathological…”
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Longitudinal SARS-CoV-2 neutralization of Omicron BA.1, BA.5 and BQ.1.1 after four vaccinations and the impact of breakthrough infections in haemodialysis patients by Platen, Louise, Liao, Bo-Hung, Tellenbach, Myriam, Cheng, Cho-Chin, Holzmann-Littig, Christopher, Christa, Catharina, Dächert, Christopher, Kappler, Verena, Bester, Romina, Werz, Maia Lucia, Schönhals, Emely, Platen, Eva, Eggerer, Peter, Tréguer, Laëtitia, Küchle, Claudius, Schmaderer, Christoph, Heemann, Uwe, Keppler, Oliver T, Renders, Lutz, Braunisch, Matthias Christoph, Protzer, Ulrike

“…ABSTRACT Background Individuals on haemodialysis (HD) are more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than the…”
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Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake by Wolf, Hanna, Graßmann, Andrea, Bester, Romina, Hossinger, André, Möhl, Christoph, Paulsen, Lydia, Groschup, Martin H, Schätzl, Hermann, Vorberg, Ina

“…Mammalian prions are unconventional infectious agents composed primarily of the misfolded aggregated host prion protein PrP, termed PrP(Sc). Prions propagate…”
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Modulation of Glycosaminoglycans Affects PrP Sc Metabolism but Does Not Block PrP Sc Uptake by Wolf, Hanna, Graßmann, Andrea, Bester, Romina, Hossinger, André, Möhl, Christoph, Paulsen, Lydia, Groschup, Martin H., Schätzl, Hermann, Vorberg, Ina

“…ABSTRACT Mammalian prions are unconventional infectious agents composed primarily of the misfolded aggregated host prion protein PrP, termed PrP Sc . Prions…”
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