Search Results - "Bester, Megan J"

Stability, Morphology, and Effects of In Vitro Digestion on the Antioxidant Properties of Polyphenol Inclusion Complexes with β-Cyclodextrin by Ntuli, Sunday, Leuschner, Machel, Bester, Megan J, Serem, June C

“…Polyphenols are inversely associated with the incidence of chronic diseases, but therapeutic use is limited by poor stability and bioaccessibility…”
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Hydrothermal Processing and In Vitro Simulated Human Digestion Affects the Bioaccessibility and Bioactivity of Phenolic Compounds in African Pumpkin (Momordica balsamina) Leaves by Moyo, Siphosanele Mafa, Serem, June C., Bester, Megan J., Mavumengwana, Vuyo, Kayitesi, Eugenie

“…The African pumpkin (Momordica balsamina) contains bioactive phenolic compounds that may assist in reducing oxidative stress in the human body. The leaves are…”
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Two Triterpenoids, ARM-2 and RA-5, From Protorhus longifolia Exhibit the Potential to Modulate Lipolysis and Lipogenesis in Cultured 3T3-L1 Adipocytes by Ndlovu, Musawenkosi, Serem, June C, Bester, Megan J, Apostolides, Zeno, Opoku, Andrew R, Mosa, Rebamang A

“…Triterpenoids have been identified as potential novel lipid-lowering drugs for the treatment of hypertriglyceridemia. This study investigated the potential…”
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Triterpenoids from Protorhus longifolia Exhibit Hypocholesterolemic Potential via Regulation of Cholesterol Biosynthesis and Stimulation of Low-Density Lipoprotein Uptake in HepG2 Cells by Ndlovu, Musawenkosi, Serem, June C., Selepe, Mamoalosi A., Opoku, Andrew R., Bester, Megan J., Apostolides, Zeno, Mosa, Rebamang A.

“…The increasing incidence of hypercholesterolemia-related diseases even in the presence of the currently available cholesterol-lowering drugs indicates a need…”
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Tryptophan End-Tagging Confers Antifungal Activity on a Tick-Derived Peptide by Triggering Reactive Oxygen Species Production by Chiramba, Court K., Möller, Dalton S., Lorenz, Christian D., Chirombo, Rumbidzai R., Mason, A. James, Bester, Megan J., Gaspar, Anabella R. M.

“…WHO has identified several Candida species including Candida albicans as critical priority fungal pathogens due to greater infection prevalence and formation…”
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QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity by van der Walt, Mandelie, Möller, Dalton S., van Wyk, Rosalind J., Ferguson, Philip M., Hind, Charlotte K., Clifford, Melanie, Do Carmo Silva, Phoebe, Sutton, J. Mark, Mason, A. James, Bester, Megan J., Gaspar, Anabella R. M.

“…Antimicrobial resistance has increased rapidly, causing daunting morbidity and mortality rates worldwide. Antimicrobial peptides (AMPs) have emerged as…”
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Generation of reactive oxygen species in relevant cell lines as a bio-indicator of oxidative effects caused by acid mine water by Myburgh, Jan G., McGaw, Lyndy J., Bester, Megan J., Iji, Oluwafikemi T., Venter, E. Annette, Serem, June C.

“…Reactive oxygen species (ROS) production and resultant oxidative stress (OS) has been implicated as a pathway of toxicity in animal species exposed to…”
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Rational in silico design of novel α-glucosidase inhibitory peptides and in vitro evaluation of promising candidates by Ibrahim, Mohammed Auwal, Bester, Megan J., Neitz, Albert W., Gaspar, Anabella R.M.

“…[Display omitted] •4210 peptides were designed and subjected to in silico simulated GIT digestion.•844 GIT resistant peptides were subjected to molecular…”
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Sorghum–cowpea composite porridge as a functional food, Part II: Antioxidant properties as affected by simulated in vitro gastrointestinal digestion by Apea-Bah, Franklin B., Minnaar, Amanda, Bester, Megan J., Duodu, Kwaku G.

“…•Digested sorghum–cowpea composite porridge has radical scavenging properties.•Composite porridges and their digests inhibit LDL oxidation and oxidative DNA…”
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Nutritional value of leafy vegetables of sub-Saharan Africa and their potential contribution to human health: A review by Uusiku, Nangula P., Oelofse, André, Duodu, Kwaku G., Bester, Megan J., Faber, Mieke

“…This paper reviews the literature on African leafy vegetables (ALVs) consumed in sub-Saharan Africa. The aim is to evaluate the nutritional value of these…”
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Structural properties of bioactive peptides with α‐glucosidase inhibitory activity by Ibrahim, Mohammed Auwal, Bester, Megan J., Neitz, Albert W. H., Gaspar, Anabella R. M.

“…Bioactive peptides are emerging as promising class of drugs that could serve as α‐glucosidase inhibitors for the treatment of type 2 diabetes. This article…”
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Effect of simulated in vitro upper gut digestion of processed cowpea beans on phenolic composition, antioxidant properties and cellular protection by Apea-Bah, Franklin B., Serem, June C., Bester, Megan J., Duodu, Kwaku G., Beta, Trust

“…[Display omitted] •In vitro digestion causes phenolic-peptide complex formation in processed cowpeas.•In vitro digestion increases radical scavenging activity…”
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Physicochemical properties, antioxidant activity and cellular protective effects of honeys from southern Africa by Serem, June C., Bester, Megan J.

“…► Examined antioxidant activity of honey, southern Africa. ► High antioxidant activity correlates with colour, polyphenolic and flavanoid content. ► Honey…”
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Phenolic composition and antioxidant properties of koose, a deep-fat fried cowpea cake by Apea-Bah, Franklin B., Serem, June C., Bester, Megan J., Duodu, Kwaku G.

“…•Deep frying of cowpea decreases phenolic content and radical scavenging capacity.•Koose contains dietary phenolic compounds that exhibit antioxidant…”
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The dipeptidyl peptidase IV inhibitory activity and multifunctional antidiabetic properties of SQSPA: Structure – Activity relationship evaluated with alanine scanning by Ibrahim, Mohammed Auwal, Serem, June C., Bester, Megan J., Gaspar, Anabella R.M.

“…Type 2 diabetes is a multifactorial disease and drugs with multifunctional properties are required. The peptide, SQSPA, was reported to be a potent and…”
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Does a sorghum–cowpea composite porridge hold promise for contributing to alleviating oxidative stress? by Apea-Bah, Franklin B., Minnaar, Amanda, Bester, Megan J., Duodu, Kwaku G.

“…•Compositing sorghum with cowpea increases total free phenolic content.•Cooking has varying effects on cereal–legume phenolics depending on type and…”
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Multiple antidiabetic effects of three α-glucosidase inhibitory peptides, PFP, YPL and YPG: Dipeptidyl peptidase–IV inhibition, suppression of lipid accumulation in differentiated 3T3-L1 adipocytes and scavenging activity on methylglyoxal by Ibrahim, Mohammed Auwal, Serem, June C., Bester, Megan J., Neitz, Albert W., Gaspar, Anabella R.M.

“…Antidiabetic agents with multiple targets have the greatest pharmaceutical potential. In this study, three α-glucosidase inhibitory peptides, PFP, YPL and YPG,…”
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Antifungal activity and mode of action of synthetic peptides derived from the tick OsDef2 defensin by Mbuayama, Kabuzi R., Taute, Helena, Strӧmstedt, Adam A., Bester, Megan J., Gaspar, Anabella R. M.

“…Candida albicans is the principal opportunistic fungal pathogen in nosocomial settings and resistance to antifungal drugs is on the rise. Antimicrobial…”
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Extruded wholegrain sorghum porridges fortified with baobab fruit and moringa leaves display bioactive phenolics-related health-promoting properties by Lubaale, John, Serem, June C., Bester, Megan J., Emmambux, M. Naushad, Duodu, Kwaku G.

“…Food-to-food fortification (FtFF) is gaining traction as a strategy to enhance nutritional value of cereal-based foods. Sorghum, a major food crop for millions…”
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Animal models used for the evaluation of antiretroviral therapies by Dias, Andreia S P, Bester, Megan J, Britz, Rozane F, Apostolides, Zeno

“…Several animal models for the study of HIV/AIDS have been established and characterized and have been widely used to study the pathogenesis of HIV/AIDS as well…”
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