Search Results - "Besteman, Elizabeth"

Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin by Vlasakova, Katerina, Bourque, Jennifer, Bailey, Wendy J, Patel, Shetal, Besteman, Elizabeth G, Gonzalez, Raymond J, Sistare, Frank D, Glaab, Warren E

“…The ability to monitor for general drug-induced tissue injury (DITI) or systemic inflammation in any tissue using blood-based accessible biomarkers would…”
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Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability by Brooks, Marjory B, Turk, James R, Guerrero, Abraham, Narayanan, Padma K, Nolan, John P, Besteman, Elizabeth G, Wilson, Dennis W, Thomas, Roberta A, Fishman, Cindy E, Thompson, Karol L, Ellinger-Ziegelbauer, Heidrun, Pierson, Jennifer B, Paulman, April, Chiang, Alan Y, Schultze, Albert E

“…Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated…”
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Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats by Gu, Yi-Zhong, Vlasakova, Katerina, Miller, Glen, Gatto, Nicholas T., Ciaccio, Paul J., Kuruvilla, Sabu, Besteman, Elizabeth G., Smith, Roger, Reynolds, Spencer J., Amin, Rupesh P., Glaab, Warren E., Wollenberg, Gordon, Lebron, Jose, Sistare, Frank D.

“…Activating mutations of the leucine-rich repeat kinase 2 (LRRK2) gene are associated with Parkinson disease (PD), prompting development of LRRK2 inhibitors as…”
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2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) or Diethylstilbestrol (DES) Cause Similar Hematopoietic Hypocellularity and Hepatocellular Changes in Murine Fetal Liver, but Differentially Affect Gene Expression by Besteman, Elizabeth G., Zimmerman, Kurt L., Huckle, William R., Prater, M. Renee, Gogal, Robert M., Holladay, Steven D.

“…TCDD and DES have immunotoxic effects, including selective diminution of T lymphocyte progenitors in the fetal liver. The histologic presentation of fetal…”
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Diethylstilbestrol (DES)-Induced Fetal Thymic Atrophy in C57BL/6 Mice: Inhibited Thymocyte Differentiation and Increased Apoptotic Cell Death by Besteman, Elizabeth G., Zimmerman, Kurt L., Holladay, Steven D.

“…Treatment of pregnant C57Bl/6 mice with 48 μg/kg diethylstilbestrol (DES) on gestation days (GDs) 14 and 16 resulted in both decreased day 18 fetal thymic…”
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Abstract 1677: Epithelial hyperplasia induced by a selective B-Raf inhibitor, WYE-130600 by Besteman, Elizabeth, Bienvenu, Jean-Guy, Chaudhary, Inder, Cukierski, Mark, Marsh, Billie, Surprenant, Beth

“…Abstract The Raf-MEK-ERK signaling pathway is critical for cell survival, growth, proliferation and tumorigenesis. The RAF kinases, ARAF, BRAF and CRAF, are…”
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Immunotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver by Besteman, Elizabeth Gayle

“…Diethylstilbestrol (DES) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been identified as immunotoxicants causing thymic atrophy, thymocyte…”
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