Search Results - "Bestehorn, Annika"
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Conceptual Advances in Control of Inflammation by the RNA-Binding Protein Tristetraprolin
Published in Frontiers in immunology (17-09-2021)“…Regulated changes in mRNA stability are critical drivers of gene expression adaptations to immunological cues. mRNA stability is controlled mainly by…”
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HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation
Published in eLife (24-03-2023)“…Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory…”
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The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains
Published in iScience (19-11-2021)“…The Linear Ubiquitin Chain Assembly Complex (LUBAC), composed of HOIP, HOIL-1L, and SHARPIN, promotes tumor necrosis factor (TNF)-dependent NF-κB signaling in…”
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An alternative splice variant of human αA-crystallin modulates the oligomer ensemble and the chaperone activity of α-crystallins
Published in Cell stress & chaperones (01-07-2017)“…In humans, ten genes encode small heat shock proteins with lens αA-crystallin and αB-crystallin representing two of the most prominent members. The canonical…”
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Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection
Published in Science advances (04-03-2022)“…Interleukin-1α (IL-1α) and IL-1β are inflammatory cytokines with important roles in health and disease. They trigger the same receptor and elicit comparable…”
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An alternative splice variant of human [alpha]A-crystallin modulates the oligomer ensemble and the chaperone activity of [alpha]-crystallins
Published in Cell stress & chaperones (01-07-2017)“…In humans, ten genes encode small heat shock proteins with lens [alpha]A-crystallin and [alpha]B-crystallin representing two of the most prominent members. The…”
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Journal Article