Search Results - "Best, Leonard"

Electrical activity in pancreatic islet cells: The VRAC hypothesis by Best, Leonard, Brown, Peter D., Sener, Abdullah, Malaisse, Willy J.

“…A major aspect of stimulation of β-cell function by glucose is the induction of electrical activity. The ionic events that underlie β-cell electrical activity…”
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Possible role of carbonic anhydrase in rat pancreatic islets: enzymatic, secretory, metabolic, ionic, and electrical aspects by Sener, Abdullah, Jijakli, Hassan, Zahedi Asl, Saleh, Courtois, Philippe, Yates, Allen P, Meuris, Sylvain, Best, Leonard C, Malaisse, Willy J

“…The presence of carbonic anhydrase (type V) was recently documented in rat and mouse pancreatic islet beta-cells by immunostaining and Western blotting. In the…”
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Cytotoxic action of methylglyoxal on insulin-secreting cells 11Abbreviations: Ho 33342, Hoechst 33342 dye; IDDM, insulin-dependent diabetes mellitus; NIDDM, non insulin-dependent diabetes mellitus; [Ca2+]i, cytosolic [Ca2+]; PI, propidium iodide by Sheader, Elizabeth A., Benson, Roderick S.P., Best, Leonard

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Insulinotropic Action of Methyl Pyruvate: Enzymatic and Metabolic Aspects by Jijakli, Hassan, Nadi, Abdellatif Bakkali, Cook, Lynda, Best, Leonard, Sener, Abdullah, Malaisse, Willy J.

“…The metabolism of methyl pyruvate was compared to that of pyruvate in isolated rat pancreatic islets. Methyl pyruvate was found to be more efficient than…”
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Curcumin induces electrical activity in rat pancreatic β-cells by activating the volume-regulated anion channel by Best, Leonard, Elliott, Austin C., Brown, Peter D.

“…Curcumin, the principal active component of turmeric, is reported to exert a number of therapeutic actions, including a hypoglycaemic/antidiabetic action. The…”
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Insulinotropic action of beta-L-glucose pentaacetate by Malaisse, W J, Best, L C, Herchuelz, A, Hiriart, M, Jijakli, H, Kadiata, M M, Larrieta-Carasco, E, Laghmich, A, Louchami, K, Mercan, D, Olivares, E, Sánchez-Soto, C, Scruel, O, Sener, A, Valverde, I, Villanueva-Peñacarrillo, M L, Viñambres, C, Zawalich, W S

“…The metabolism of beta-L-glucose pentaacetate and its interference with the catabolism of L-[U-14C]glutamine, [U-14C]palmitate, D-[U-14C]glucose, and…”
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Stimulus-secretion coupling of arginine-induced insulin release: comparison between the cationic amino acid and its methyl ester by Sener, A, Best, L C, Yates, A P, Kadiata, M M, Olivares, E, Louchami, K, Jijakli, H, Ladrière, L, Malaisse, W J

“…The role currently ascribed to the accumulation of L-arginine in the pancreatic islet B-cell as a determinant of its insulinotropic action was reevaluated by…”
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Study of a glucose-activated anion-selective channel in rat pancreatic beta-cells by Best, Leonard

“…Cell-attached channel recordings were made of an inward channel current in isolated rat pancreatic beta-cells incubated in the presence of diazoxide to clamp…”
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Opposing effects of tenidap on the volume-regulated anion channel and K ATP channel activity in rat pancreatic β-cells by Best, Leonard, Brown, Peter D., Sener, Abdullah, Malaisse, Willy J.

“…Tenidap (5-chloro-2-hydroxy-3-(thiophene-2-carbonyl)indole-1-carboxamide) is a non-steroidal anti-inflammatory and anti-rheumatic drug with several cellular…”
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Study of a glucose-activated anion-selective channel in rat pancreatic [beta]-cells by Best, Leonard

“…Cell-attached channel recordings were made of an inward channel current in isolated rat pancreatic β-cells incubated in the presence of diazoxide to clamp the…”
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Inhibition of glucose-induced electrical activity by 4-hydroxytamoxifen in rat pancreatic β-cells by Best, Leonard

“…The antioestrogen 4-hydroxytamoxifen (10 or 2 μM) abolished the generation of action potentials and repolarized the membrane potential in rat pancreatic…”
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Opposing effects of tenidap on the volume-regulated anion channel and KATP channel activity in rat pancreatic β-cells by BEST, Leonard, BROWN, Peter D, SENER, Abdullah, MALAISSE, Willy J

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Glucose-sensitive conductances in rat pancreatic β-cells: contribution to electrical activity by Best, Leonard

“…The perforated patch technique was used to assess the relative contribution of K ATP channel activity, assessed from input conductance ( G input), and…”
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Cell-attached recordings of the volume-sensitive anion channel in rat pancreatic β-cells by Best, Leonard

“…The cell-attached configuration of the patch-clamp technique was used to study the volume-sensitive anion conductance in isolated rat pancreatic β-cells at the…”
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Depolarisation of guinea-pig visceral smooth muscle causes hydrolysis of inositol phospholipids by BEST, L, BOLTON, T. B

“…Increasing concentrations of KCl caused a progressive stimulation of contractile activity in guinea-pig jejunal longitudinal smooth muscle strips, accompanied…”
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Contrasting Effects of Glycerol and Urea Transport on Rat Pancreatic β-Cell Function by Best, Leonard, Brown, Peter D., Yates, Allen P., Perret, Jason, Virreira, Myrna, Beauwens, Renaud, Malaisse, Willy J., Sener, Abdullah, Delporte, Christine

“…Background/aims: Pancreatic β-cell function is influenced by changes in cell volume. Such volume changes depend on water permeability of the plasma membrane,…”
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Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents by Best, Leonard, Yates, Allen P., Decher, Neils, Steinmeyer, Klaus, Nilius, Bernd

“…We have investigated the effects of the ethacrynic acid derivative 4-(2-butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), an inhibitor…”
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Actions of antipsychotic drugs on pancreatic β-cell function: contrasting effects of clozapine and haloperidol by Best, Leonard, Yates, Allen P., Reynolds, Gavin P.

“…The use of antipsychotic drugs is known to be associated with a number of adverse metabolic side effects, including diabetes mellitus. These side effects could…”
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Actions of antipsychotic drugs on pancreatic b-cell function: contrasting effects of clozapine and haloperidol by Best, Leonard, Yates, Allen P, Reynolds, Gavin P

“…The use of antipsychotic drugs is known to be associated with a number of adverse metabolic side effects, including diabetes mellitus. These side effects could…”
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Opposing effects of tenidap on the volume-regulated anion channel and K(ATP) channel activity in rat pancreatic beta-cells by Best, Leonard, Brown, Peter D, Sener, Abdullah, Malaisse, Willy J

“…Tenidap (5-chloro-2-hydroxy-3-(thiophene-2-carbonyl)indole-1-carboxamide) is a non-steroidal anti-inflammatory and anti-rheumatic drug with several cellular…”
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