Search Results - "Best, Deborah S"

The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat by Davis, Lori K., Murr, Ashley S., Best, Deborah S., Fraites, Melanie J.P., Zorrilla, Leah M., Narotsky, Michael G., Stoker, Tammy E., Goldman, Jerome M., Cooper, Ralph L.

“…Atrazine (ATR) is an herbicide that exerts negative reproductive effects. We examined the effects of vehicle or ATR (1, 5, 20 and 100 mg/kg-d), administered to…”
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Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides by Tully, Douglas B., Bao, Wenjun, Goetz, Amber K., Blystone, Chad R., Ren, Hongzu, Schmid, Judith E., Strader, Lillian F., Wood, Carmen R., Best, Deborah S., Narotsky, Michael G., Wolf, Douglas C., Rockett, John C., Dix, David J.

“…Four triazole fungicides were studied using toxicogenomic techniques to identify potential mechanisms of action. Adult male Sprague-Dawley rats were dosed for…”
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Gestational atrazine exposure: Effects on male reproductive development and metabolite distribution in the dam, fetus, and neonate by Fraites, Melanie J.P., Narotsky, Michael G., Best, Deborah S., Stoker, Tammy E., Davis, Lori K., Goldman, Jerome M., Hotchkiss, Michelle G., Klinefelter, Gary R., Kamel, Alaa, Qian, Yaorong, Podhorniak, Lynda, Cooper, Ralph L.

“…Few studies have investigated the long-term effects of atrazine (ATR) following in utero exposure. We evaluated the effects of gestational exposure of Sprague…”
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Reproductive toxicity of a mixture of regulated drinking-water disinfection by-products in a multigenerational rat bioassay by Narotsky, Michael G, Klinefelter, Gary R, Goldman, Jerome M, DeAngelo, Anthony B, Best, Deborah S, McDonald, Anthony, Strader, Lillian F, Murr, Ashley S, Suarez, Juan D, George, Michael H, Hunter, E Sidney, Simmons, Jane Ellen

“…Trihalomethanes (THMs) and haloacetic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is…”
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Pregnancy loss and eye malformations in offspring of F344 rats following gestational exposure to mixtures of regulated trihalomethanes and haloacetic acids by Narotsky, Michael G., Best, Deborah S., McDonald, Anthony, Godin, Elizabeth A., Hunter, E. Sidney, Simmons, Jane Ellen

“…▶ Both trihalomethanes and haloacetic acids caused full-litter resorption in F344 rats. ▶ Haloacetic acids caused eye malformations (anophthalmia,…”
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Disruption of Testosterone Homeostasis as a Mode of Action for the Reproductive Toxicity of Triazole Fungicides in the Male Rat by Goetz, Amber K., Ren, Hongzu, Schmid, Judith E., Blystone, Chad R., Thillainadarajah, Inthirany, Best, Deborah S., Nichols, Harriette P., Strader, Lillian F., Wolf, Douglas C., Narotsky, Michael G., Rockett, John C., Dix, David J.

“…Triazole fungicides associated with a range of reported male reproductive effects in experimental animals were selected to assess potential toxic modes of…”
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Comprehensive Assessment of a Chlorinated Drinking Water Concentrate in a Rat Multigenerational Reproductive Toxicity Study by Narotsky, Michael G, Klinefelter, Gary R, Goldman, Jerome M, Best, Deborah S, McDonald, Anthony, Strader, Lillian F, Suarez, Juan D, Murr, Ashley S, Thillainadarajah, Inthirany, Hunter, E. Sidney, Richardson, Susan D, Speth, Thomas F, Miltner, Richard J, Pressman, Jonathan G, Teuschler, Linda K, Rice, Glenn E, Moser, Virginia C, Luebke, Robert W, Simmons, Jane Ellen

“…Some epidemiological studies report associations between drinking water disinfection byproducts (DBPs) and adverse reproductive/developmental effects, e.g.,…”
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Atrazine does not induce pica behavior at doses that increase hypothalamic–pituitary–adrenal axis activation and cause conditioned taste avoidance by Hotchkiss, Michelle Gatien, Best, Deborah S, Cooper, Ralph L, Laws, Susan C

“…Abstract Previous work has shown that a single oral administration of atrazine (ATR), a chlorotriazine herbicide, causes rapid increases in plasma…”
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Effect of conazole fungicides on reproductive development in the female rat by Rockett, John C., Narotsky, Michael G., Thompson, Kary E., Thillainadarajah, Inthirany, Blystone, Chad R., Goetz, Amber K., Ren, Hongzu, Best, Deborah S., Murrell, Rachel N., Nichols, Harriette P., Schmid, Judith E., Wolf, Douglas C., Dix, David J.

“…Three triazole fungicides were evaluated for effects on female rat reproductive development. Rats were exposed via feed to propiconazole (P) (100, 500, or 2500…”
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Developmental Toxicity Evaluations of Whole Mixtures of Disinfection By-products using Concentrated Drinking Water in Rats: Gestational and Lactational Effects of Sulfate and Sodium by Narotsky, Michael G., Pressman, Jonathan G., Miltner, Richard J., Speth, Thomas F., Teuschler, Linda K., Rice, Glenn E., Richardson, Susan D., Best, Deborah S., McDonald, Anthony, Hunter III, E. Sidney, Simmons, Jane Ellen

“…A developmental toxicity bioassay was used in three experiments to evaluate water concentrates for suitability in multigenerational studies. First, chlorinated…”
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Integrated Disinfection By-Products Mixtures Research: Assessment of Developmental Toxicity in Sprague-Dawley Rats Exposed to Concentrates of Water Disinfected by Chlorination and Ozonation/Postchlorination by Narotsky, Michael G., Best, Deborah S., Rogers, Ellen H., McDonald, Anthony, Sey, Yusupha M., Simmons, Jane Ellen

“…Epidemiological and animal toxicity studies have raised concerns regarding possible adverse health effects of disinfection by-products (DBPs) found in drinking…”
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Serum Hormone Characterization and Exogeneous Hormone Rescue of Bromodichloromethane-Induced Pregnancy Loss in the F344 Rat by Bielmeier, Susan R., Best, Deborah S., Narotsky, Michael G.

“…Previously, we demonstrated that bromodichloromethane (BDCM), a drinking water disinfection by-product, causes pregnancy loss in F344 rats when given on…”
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Bromodichloromethane Inhibits Human Placental Trophoblast Differentiation by Chen, Jiangang, Thirkill, Twanda L., Lohstroh, Peter N., Bielmeier, Susan R., Narotsky, Michael G., Best, Deborah S., Harrison, Randy A., Natarajan, Kala, Pegram, Rex A., Overstreet, James W., Lasley, Bill L., Douglas, Gordon C.

“…Epidemiological data suggest an association between exposures to bromodichloromethane (BDCM), a trihalomethane found in drinking water as a result of drinking…”
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Pregnancy loss in the rat caused by bromodichloromethane by BIELMEIER, Susan R, BEST, Deborah S, GUIDICI, Dorothy L, NAROTSKY, Michael G

“…Bromodichloromethane (BDCM), a trihalomethane, is a by-product of the chlorination of drinking water. In a recent epidemiological study, consumption of BDCM…”
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Teratogenic effects of retinoic acid are modulated in mice lacking expression of epidermal growth factor and transforming growth factor-α by Abbott, Barbara D., Best, Deborah S., Narotsky, Michael G.

“…BACKGROUND Epidermal growth factor (EGF) and transforming growth factor‐α (TGFα) regulate cell proliferation and differentiation in the embryo. The induction…”
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Teratogenic effects of retinoic acid are modulated in mice lacking expression of epidermal growth factor and transforming growth factor-? by Abbott, Barbara D., Best, Deborah S., Narotsky, Michael G.

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Effect of Bromodichloromethane on Chorionic Gonadotrophin Secretion by Human Placental Trophoblast Cultures by Chen, Jiangang, Douglas, Gordon C., Thirkill, Twanda L., Lohstroh, Peter N., Bielmeier, Susan R., Narotsky, Michael G., Best, Deborah S., Harrison, Randy A., Natarajan, Kala, Pegram, Rex A., Overstreet, James W., Lasley, Bill L.

“…Bromodichloromethane (BDCM) is a trihalomethane found in drinking water as a by-product of disinfection processes. BDCM is hepatotoxic and nephrotoxic in…”
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Strain comparisons of atrazine-induced pregnancy loss in the rat by Narotsky, Michael G., Best, Deborah S., Guidici, Dorothy L., Cooper, Ralph L.

“…Atrazine was administered by gavage, in 1% methylcellulose, to F344 Sprague-Dawley (SD), and Long Evans (LE) rats at 0, 25, 50, 100, or 200 mg/kg/day on…”
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Strain comparisons of atrazine-induced pregnancy loss in the rats by NAROTSKY, Michael G, BEST, Deborah S, GUIDICI, Dorothy L, COOPER, Ralph L

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Strain comparisons of atrazine-induced pregnancy loss in the rat☆11☆Disclaimer: The information in this document has been funded wholly by the US Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use by Narotsky, Michael G., Best, Deborah S., Guidici, Dorothy L., Cooper, Ralph L.

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