Search Results - "Best, Carolyn J M"

Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo by GILLS, Joell J, LOPICCOLO, Jaclyn, HOLLANDER, M. Christine, KAWABATA, Shigeru, TSOKOS, Maria, FIGG, William D, STEEG, Patricia S, DENNIS, Phillip A, TSURUTANI, Junji, SHOEMAKER, Robert H, BEST, Carolyn J. M, ABU-ASAB, Mones S, BOROJERDI, Jennifer, WARFEL, Noel A, GARDNER, Erin R, DANISH, Matthew

“…Purpose: The development of new cancer drugs is slow and costly. HIV protease inhibitors are Food and Drug Administration approved for HIV patients. Because…”
Get full text

Molecular Alterations in Primary Prostate Cancer after Androgen Ablation Therapy by BEST, Carolyn J. M, GILLESPIE, John W, GONZALEZ, Sergio, VELASCO, Alfredo, LINEHAN, W. Marston, MATUSIK, Robert J, PRICE, Douglas K, FIGG, William D, EMMERT-BUCK, Michael R, CHUAQUI, Rodrigo F, YAJUN YI, CHANDRAMOULI, Gadisetti V. R, PERLMUTTER, Mark A, GATHRIGHT, Yvonne, ERICKSON, Heidi S, GEORGEVICH, Lauren, TANGREA, Michael A, DURAY, Paul H

“…Purpose: After an initial response to androgen ablation, most prostate tumors recur, ultimately progressing to highly aggressive androgen-independent cancer…”
Get full text

Optimal molecular profiling of tissue and tissue components : Defining the best processing and microdissection methods for biomedical applications by BOVA, G. Steven, ELTOUM, Isam A, KIERNAN, John A, SIEGAL, Gene P, FROST, Andra R, BEST, Carolyn J. M, GILLESPIE, John W, SU, Gloria H, EMMERT-BUCK, Michael R

“…Isolation of well-preserved pure cell populations is a prerequisite for sound studies of the molecular basis of any tissue-based biological phenomenon. This…”
Get full text

Advancing bladder preservation: Biomarkers, decision-making, and therapy by McConkey, David, Best, Carolyn J.M., Gumminger, Julia A., Olumi, Aria F.

Get full text

Meeting report on the NIDDK/AUA Workshop on Congenital Anomalies of External Genitalia: challenges and opportunities for translational research by Stadler, H. Scott, Peters, Craig A., Sturm, Renea M., Baker, Linda A., Best, Carolyn J.M., Bird, Victoria Y., Geller, Frank, Hoshizaki, Deborah K., Knudsen, Thomas B., Norton, Jenna M., Romao, Rodrigo L.P., Cohn, Martin J.

“…Congenital anomalies of the external genitalia (CAEG) are a prevalent and serious public health concern with lifelong impacts on the urinary function, sexual…”
Get full text

Alterations in gene expression profiles during prostate cancer progression: Functional correlations to tumorigenicity and down-regulation of Selenoprotein-P in mouse and human tumors by CALVO, Alfonso, NIANQING XIAO, KANG, Jason, BEST, Carolyn J. M, LEIVA, Isabel, EMMERT-BUCK, Michael R, JORCYK, Cheryl, GREEN, Jeffrey E

“…To identify molecular changes that occur during prostate tumor progression, we have characterized a series of prostate cancer cell lines isolated at different…”
Get full text

Molecular differentiation of high- and moderate-grade human prostate cancer by cDNA microarray analysis by Best, Carolyn J M, Leiva, Isabel M, Chuaqui, Rodrigo F, Gillespie, John W, Duray, Paul H, Murgai, Meera, Zhao, Yingdong, Simon, Richard, Kang, Jason J, Green, Jeffrey E, Bostwick, David G, Linehan, W Marston, Emmert-Buck, Michael R

“…The prognosis of men with moderate-grade prostate cancer is uncertain. At present, there are few if any reliable molecular markers that can distinguish…”
Get more information

Increased expression of VEGF121/VEGF165–189 ratio results in a significant enhancement of human prostate tumor angiogenesis by Catena, Raul, Muniz‐Medina, Vanessa, Moralejo, Beatriz, Javierre, Biola, Best, Carolyn J.M., Emmert‐Buck, Michael R., Green, Jeffrey E., Baker, Carl C., Calvo, Alfonso

“…Vascular endothelial growth factor (VEGF) is a proangiogenic factor upregulated in many tumors. The alternative splicing of VEGF mRNA renders 3 major isoforms…”
Get full text

Post-analysis follow-up and validation of microarray experiments by Chuaqui, Rodrigo F, Bonner, Robert F, Best, Carolyn J M, Gillespie, John W, Flaig, Michael J, Hewitt, Stephen M, Phillips, John L, Krizman, David B, Tangrea, Michael A, Ahram, Mamoun, Linehan, W Marston, Knezevic, Vladimir, Emmert-Buck, Michael R

“…Measurement of gene-expression profiles using microarray technology is becoming increasingly popular among the biomedical research community. Although there…”
Get full text

Proteomic analysis of human prostate cancer by Ahram, Mamoun, Best, Carolyn J. M., Flaig, Michael J., Gillespie, John W., Leiva, Isabel M., Chuaqui, Rodrigo F., Zhou, Ge, Shu, Hungjun, Duray, Paul H., Linehan, W. Marston, Raffeld, Mark, Ornstein, David K., Zhao, Yingming, Petricoin III, Emanuel F., Emmert-Buck, Michael R.

“…Proteomics is a promising approach in the identification of proteins and biochemical pathways involved in tumorigenesis. In an effort to discover such proteins…”
Get full text

H-RAS-Transformed NRK-52E Renal Epithelial Cells Have Altered Growth, Morphology, and Cytoskeletal Structure That Correlates with Renal Cell Carcinoma in vivo by Carolyn J. M. Best, Lee R. Tanzer, Phelps, Patricia C., Ronald L. Merriman, George G. Boder, Trump, Benjamin F., Kathryn A. Elliget

“…We studied the effect of the ras oncogene on the growth kinetics, morphology, cytoskeletal structure, and tumorigenicity of the widely used NRK-52E rat kidney…”
Get full text

Expression microdissection: operator-independent retrieval of cells for molecular profiling by Tangrea, Michael A, Chuaqui, Rodrigo F, Gillespie, John W, Ahram, Mamoun, Gannot, Gallya, Wallis, Benjamin S, Best, Carolyn J M, Linehan, W Marston, Liotta, Lance A, Pohida, Thomas J, Bonner, Robert F, Emmert-Buck, Michael R

“…Tissue microdissection is an important method for the study of disease states. However, it is difficult to perform high-throughput molecular analysis with…”
Get more information

New approaches to molecular profiling of tissue samples by Best, C J, Gillespie, J W, Englert, C R, Swalwell, J I, Pfeifer, J, Krizman, D B, Petricoin, E F, Liotta, L A, Emmert-Buck, M R

“…Figures on http://www.esacp.org/acp/2000/20-1/best.htm…”
Get full text

Evaluation of Non-Formalin Tissue Fixation for Molecular Profiling Studies by Gillespie, John W., Best, Carolyn J.M., Bichsel, Verena E., Cole, Kristina A., Greenhut, Susan F., Hewitt, Stephen M., Ahram, Mamoun, Gathright, Yvonne B., Merino, Maria J., Strausberg, Robert L., Epstein, Jonathan I., Hamilton, Stanley R., Gannot, Gallya, Baibakova, Galina V., Calvert, Valerie S., Flaig, Michael J., Chuaqui, Rodrigo F., Herring, Judi C., Pfeifer, John, Petricoin, Emmanuel F., Linehan, W. Marston, Duray, Paul H., Bova, G. Steven, Emmert-Buck, Michael R.

“…Using a general strategy for evaluating clinical tissue specimens, we found that 70% ethanol fixation and paraffin embedding is a useful method for molecular…”
Get full text

Comparison of Snap Freezing versus Ethanol Fixation for Gene Expression Profiling of Tissue Specimens by Perlmutter, Mark A., Best, Carolyn J.M., Gillespie, John W., Gathright, Yvonne, González, Sergio, Velasco, Alfredo, Linehan, W. Marston, Emmert-Buck, Michael R., Chuaqui, Rodrigo F.

“…Frozen tissue specimens are the gold standard for molecular analysis. However, snap freezing presents several challenges regarding collection and storage of…”
Get full text

Molecular Profiling of Cancer by Gillespie, John W., Gannot, Gallya, Tangrea, Michael A., Ahram, Mamoun, Best, Carolyn J.M., Bichsel, Verena E., Petricoin, Emmanuel F., Emmert-Buck, Michael R., Chuaqui, Rodrigo F.

“…The objective of molecular profiling of cancer is to determine the differential expression of genes and proteins from human tissue in the progression from…”
Get full text

Layered expression scanning: multiplex analysis of RNA and protein gels by Tangrea, Michael A, Flaig, Michael J, Ramesh, Arun, Best, Carolyn J M, Baibakov, Galina V, Hewitt, Stephen M, Mitchell, Capre D, Hartmann, Dan-Paul, Knezevic, Vladimir, Emmert-Buck, Michael R, Chuaqui, Rodrigo F

“…Northern blots and immunoblots are utilized in laboratories worldwide and offer several important features for analyzing mRNA and protein expression, including…”
Get full text

Post-analysis follow-up and validation of microarray experiments by CHUAQUI, Rodrigo F, BONNER, Robert F, LINEHAN, W. Marston, KNEZEVIC, Vladimir, EMMERT-BUCK, Michael R, BEST, Carolyn J. M, GILLESPIE, John W, FLAIG, Michael J, HEWITT, Stephen M, PHILLIPS, John L, KRIZMAN, David B, TANGREA, Michael A, AHRAM, Mamoun

Get full text

Optimal molecular profiling of tissue and tissue components: defining the best processing and microdissection methods for biomedical applications by Bova, G Steven, Eltoum, Isam A, Kiernan, John A, Siegal, Gene P, Frost, Andra R, Best, Carolyn J M, Gillespie, John W, Emmert-Buck, Michael R

“…Isolation of well-preserved pure cell populations is a prerequisite for sound studies of the molecular basis of pancreatic malignancy and other biological…”
Get more information

Molecular profiling of tissue samples using laser capture microdissection by Best, C J, Emmert-Buck, M R

“…The management of cancer and other genetically based diseases is far from optimal in even our most advanced medical centers. There is still uncertainty…”
Get more information