Current Role of Modern Chromatography with Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy in the Investigation of Biomarkers of Endometriosis

Endometriosis has a wide range of clinical manifestations, and the disease course is unpredictable, making the diagnosis a challenging task. Despite significant advances in the pathophysiology of endometriosis and various proposed theories, the exact etiology is not fully understood and is still unk...

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Published in:	Critical reviews in analytical chemistry Vol. 54; no. 7; pp. 2110 - 2133
Main Authors:	Kartsova, Liudmila Alekseevna, Bessonova, Elena Andreevna, Deev, Vladislav Aleksandrovich, Kolobova, Ekaterina Alekseevna
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 02-10-2024 Taylor & Francis Ltd
Subjects:	Biomarkers Biomarkers - analysis Biomarkers - metabolism Chromatography chromatography mass spectrometry Chromatography, Liquid - methods Diagnosis Endometriosis Endometriosis - diagnosis Endometriosis - metabolism Female Humans Lipid metabolism Lipids Liquid chromatography Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Metabolites NMR NMR spectroscopy Nuclear magnetic resonance omics technologies Peptides Scientific imaging Spectroscopic analysis Spectroscopy omics technologies Endometriosis chromatography mass spectrometry NMR spectroscopy biomarkers
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Summary:	Endometriosis has a wide range of clinical manifestations, and the disease course is unpredictable, making the diagnosis a challenging task. Despite significant advances in the pathophysiology of endometriosis and various proposed theories, the exact etiology is not fully understood and is still unknown. The most commonly used biomarker of endometriosis is CA-125, however, it is nonspecific and is applied for cancers diagnosis. Therefore, the development of reliable noninvasive diagnostic tests for the early diagnosis of endometriosis remains one of the top priorities. Omics technologies are very promising approaches for constructing diagnostic models and biomarker discovery. Their use can greatly facilitate the study of such a complex disease as endometriosis. Nowadays, powerful analytical platforms commonly used in omics, such as gas and liquid chromatography with mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, have proven to be a promising tools for biomarker discovery. The aim of this review is to summarize the various features of the analytical approaches, practical challenges and features of gas and liquid chromatography with MS and NMR spectroscopy (including sample processing protocols, technological advancements, and methodology) used for profiling of metabolites, lipids, peptides and proteins in physiological fluids and tissues from patients with endometriosis. In addition, this report devotes special attention to the issue of how comprehensive analyses of these profiles can effectively contribute to the study of endometriosis. The search query included reports published between 2012 and 2022 years in PubMed, Web-of-Science, SCOPUS, Science Direct.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1040-8347 1547-6510 1547-6510
DOI:	10.1080/10408347.2022.2156770