Search Results - "Bessone, Ivan Fernandez"

DYRK1A Regulates the Bidirectional Axonal Transport of APP in Human-Derived Neurons by Fernandez Bessone, Iván, Navarro, Jordi, Martinez, Emanuel, Karmirian, Karina, Holubiec, Mariana, Alloatti, Matias, Goto-Silva, Livia, Arnaiz Yepez, Cayetana, Martins-de-Souza, Daniel, Minardi Nascimento, Juliana, Bruno, Luciana, Saez, Trinidad M, Rehen, Stevens K, Falzone, Tomás L

“…triplication in Down's syndrome and its overexpression in Alzheimer's disease suggest a role for increased DYRK1A activity in the abnormal metabolism of APP…”
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Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance by Saez, Trinidad M M, Fernandez Bessone, Iván, Rodriguez, María S, Alloatti, Matías, Otero, María G, Cromberg, Lucas E, Pozo Devoto, Victorio M, Oubiña, Gonzalo, Sosa, Lucas, Buffone, Mariano G, Gelman, Diego M, Falzone, Tomás L

“…Endocannabinoids (eCB) modulate growth cone dynamics and axonal pathfinding through the stimulation of cannabinoid type-1 receptors (CB1R), the function of…”
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Mitochondrial vulnerability to oxidation in human brain organoids modelling Alzheimer's disease by Holubiec, Mariana I., Alloatti, Matias, Bianchelli, Julieta, Greloni, Francisco, Arnaiz, Cayetana, Gonzalez Prinz, Melina, Fernandez Bessone, Ivan, Pozo Devoto, Victorio, Falzone, Tomas L.

“…Reactive Oxygen Species (ROS) and mitochondrial dysfunction are implicated in the pathogenesis of Alzheimer's disease (AD), a common neurodegenerative disorder…”
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Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors by Santofimia-Castaño, Patricia, Fraunhoffer, Nicolas, Liu, Xi, Bessone, Ivan Fernandez, di Magliano, Marina Pasca, Audebert, Stephane, Camoin, Luc, Estaras, Matias, Brenière, Manon, Modesti, Mauro, Lomberk, Gwen, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan

“…We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven…”
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Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes by Otero, María Gabriela, Fernandez Bessone, Ivan, Hallberg, Alan Earle, Cromberg, Lucas Eneas, De Rossi, María Cecilia, Saez, Trinidad M, Levi, Valeria, Almenar-Queralt, Angels, Falzone, Tomás Luis

“…Alzheimer disease (AD) pathology includes the accumulation of poly-ubiquitylated (also known as poly-ubiquitinated) proteins and failures in…”
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Tau conditional reduction in human‐derived neurons exposes novel tau‐associated functions in electrical activity and axonal transport by Bessone, Ivan Fernandez, Damianich, Ana, Pedroncini, Olivia, Holubiec, Mariana, Saez, Trinidad, Burgin, Antonia Marin, Avale, Maria‐Elena, Falzone, Tomas

“…Background Abnormal tau accumulation is the hallmark of neurodegenerative diseases, and gain‐of‐toxic tau function has been pointed as triggering neuronal…”
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Designing new targeted therapies against stress granules formation in Kras-dependent pancreatic cancer by Santofimia-Castaño, Patricia, Fraunhoffer, Nicolas Fraunhoffer, Liu, Xi, Fernandez-Bessone, Ivan, Pasca di Magliano, Marina, Audebert, Stephane, Camoin, Luc, Modesti, Mauro, Lomberk, Gwen Alyce, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan

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PROTEASOME ACTIVITY INVOLVED IN THE MODIFICATIONS OF APP METABOLISM AND THE INDUCTION OF ALZHEIMER PATHOLOGY by Alloatti, Matias, Bessone, Ivan Fernandez, Hallberg, Alan, Otero, Maria Gabriela, Saez, Trinidad, Rehen, Stevens, Falzone, Tomas

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Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras G12D -driven tumors by Santofimia-Castaño, Patricia, Fraunhoffer, Nicolas, Liu, Xi, Bessone, Ivan Fernandez, di Magliano, Marina Pasca, Audebert, Stephane, Camoin, Luc, Estaras, Matias, Brenière, Manon, Modesti, Mauro, Lomberk, Gwen, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan

“…We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid-liquid phase separation (LLPS). NUPR1-driven…”
Get full text

Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance by Saez, Trinidad M, Fernandez Bessone, Iván, Rodriguez, María S, Alloatti, Matías, Otero, María G, Cromberg, Lucas E, Pozo Devoto, Victorio M, Oubiña, Gonzalo, Sosa, Lucas, Buffone, Mariano G, Gelman, Diego M, Falzone, Tomás L

“…Endocannabinoids modulate growth cone dynamics and axonal pathfinding through the stimulation of cannabinoid type-1 receptors (CB1R) which function depends on…”
Get full text