Search Results - "Besson, Laurie"

Alteration of Natural Killer cell phenotype and function in obese individuals by Viel, Sébastien, Besson, Laurie, Charrier, Emily, Marçais, Antoine, Disse, Emmanuel, Bienvenu, Jacques, Walzer, Thierry, Dumontet, Charles

“…Abstract Obesity is associated with increased cancer rates and higher susceptibility to infections. The adipose tissue of obese individuals is inflammatory and…”
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Comparison of RT-qPCR and Nanostring in the measurement of blood interferon response for the diagnosis of type I interferonopathies by Pescarmona, Rémi, Belot, Alexandre, Villard, Marine, Besson, Laurie, Lopez, Jonathan, Mosnier, Isabelle, Mathieu, Anne-Laure, Lombard, Christine, Garnier, Lorna, Frachette, Cécile, Walzer, Thierry, Viel, Sébastien

“…•The panel of ISGs we used for the IFN signature is quite specific for type I IFN.•RT-qPCR and Nanostring are two comparable methods to perform the IFN…”
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Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion by Marotel, Marie, Villard, Marine, Drouillard, Annabelle, Tout, Issam, Besson, Laurie, Allatif, Omran, Pujol, Marine, Rocca, Yamila, Ainouze, Michelle, Roblot, Guillaume, Viel, Sébastien, Gomez, Melissa, Loustaud, Veronique, Alain, Sophie, Durantel, David, Walzer, Thierry, Hasan, Uzma, Marçais, Antoine

“…Antiviral effectors such as natural killer (NK) cells have impaired functions in chronic hepatitis B (CHB) patients. The molecular mechanism responsible for…”
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High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors by Marçais, Antoine, Marotel, Marie, Degouve, Sophie, Koenig, Alice, Fauteux-Daniel, Sébastien, Drouillard, Annabelle, Schlums, Heinrich, Viel, Sébastien, Besson, Laurie, Allatif, Omran, Bléry, Mathieu, Vivier, Eric, Bryceson, Yenan, Thaunat, Olivier, Walzer, Thierry

“…NK cell education is the process through which chronic engagement of inhibitory NK cell receptors by self MHC-I molecules preserves cellular responsiveness…”
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One-Year Follow-Up of Natural Killer Cell Activity in Multiple Myeloma Patients Treated With Adjuvant Lenalidomide Therapy by Besson, Laurie, Charrier, Emily, Karlin, Lionel, Allatif, Omran, Marçais, Antoine, Rouzaire, Paul, Belmont, Lucie, Attal, Michel, Lombard, Christine, Salles, Gilles, Walzer, Thierry, Viel, Sébastien

“…Multiple myeloma (MM) is a proliferation of tumoral plasma B cells that is still incurable. Natural killer (NK) cells can recognize and kill MM cells and can…”
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MDR1-expressing CD4+ T cells with Th1.17 features resist to neoadjuvant chemotherapy and are associated with breast cancer clinical response by Di Roio, Anthony, Hubert, Margaux, Besson, Laurie, Bossennec, Marion, Rodriguez, Céline, Grinberg-Bleyer, Yenkel, Lalle, Guilhem, Moudombi, Lyvia, Schneider, Raphael, Degletagne, Cyril, Treilleux, Isabelle, Campbell, Daniel J, Metzger, Séverine, Duhen, Thomas, Trédan, Olivier, Caux, Christophe, Ménétrier-Caux, Christine

“…BackgroundMultidrug resistance-1 (MDR1) transporter limits the intracellular accumulation of chemotherapies (paclitaxel, anthracyclines) used in breast cancer…”
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Recruitment and Expansion of Tregs Cells in the Tumor Environment-How to Target Them? by Cinier, Justine, Hubert, Margaux, Besson, Laurie, Di Roio, Anthony, Rodriguez, Céline, Lombardi, Vincent, Caux, Christophe, Ménétrier-Caux, Christine

“…Regulatory T cells (Tregs) are present in a large majority of solid tumors and are mainly associated with a poor prognosis, as their major function is to…”
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Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells by Viel, Sébastien, Besson, Laurie, Marotel, Marie, Walzer, Thierry, Marçais, Antoine

“…The control of cellular metabolism is now recognized as key to regulate functional properties of immune effectors such as T or Natural Killer (NK) cells…”
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Cutting Edge: mTORC1 Inhibition in Metastatic Breast Cancer Patients Negatively Affects Peripheral NK Cell Maturation and Number by Besson, Laurie, Mery, Benoite, Morelle, Magali, Rocca, Yamila, Heudel, Pierre Etienne, You, Benoit, Bachelot, Thomas, Ray-Coquard, Isabelle, Villard, Marine, Charrier, Emily, Parant, François, Viel, Sébastien, Garin, Gwenaële, Mayet, Romaine, Perol, David, Walzer, Thierry, Tredan, Olivier, Marçais, Antoine

“…NK cells are cytotoxic lymphocytes displaying strong antimetastatic activity. Mouse models and in vitro studies suggest a prominent role of the mechanistic…”
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Natural Killer Cells Display an Activated Phenotype but Reduced Effector Functions in Obese Patients by Viel, Sebastien, Besson, Laurie, Charrier, Emily, Bienvenu, Jacques, Disse, Emmanuel, Walzer, Thierry, Dumontet, Charles

“…The impact of adiposity on the immune system remains largely unexplored. While obesity has been suggested to be a predisposing or adverse prognostic factor in…”
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Deletion of Inflammasome Components Is Not Sufficient To Prevent Fatal Inflammation in Models of Familial Hemophagocytic Lymphohistiocytosis by Fauteux-Daniel, Sébastien, Viel, Sébastien, Besson, Laurie, Zhang, Jiang, Marotel, Marie, Mathieu, Anne-Laure, Pescarmona, Rémi, Charrier, Emily, Henry, Thomas, Belot, Alexandre, Walzer, Thierry

“…Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition that occurs in patients with genetic defects of cytotoxicity (familial HLH [FHL])…”
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Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay by Hayek, Simon, Bekaddour, Nassima, Besson, Laurie, Alves de Sousa, Rodolphe, Pietrancosta, Nicolas, Viel, Sébastien, Smith, Nikaia, Jacob, Yves, Nisole, Sébastien, Mandal, Rupasri, Wishart, David S, Walzer, Thierry, Herbeuval, Jean-Philippe, Vidalain, Pierre-Olivier

“…Natural killer (NK) cells are essential players of the innate immune response that secrete cytolytic factors and cytokines such as IFN-γ when contacting…”
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