Search Results - "Bessire, Andrew J."

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry by Ballard, T. Eric, Dahal, Upendra P., Bessire, Andrew J., Schneider, Richard P., Geoghegan, Kieran F., Vaz, Alfin D. N.

“…Rationale The covalent modification of proteins by toxicants, new chemical entities or drug molecules, either by metabolic activation or the presence of…”
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LC/MS Methods for Studying Lysosomal ADC Catabolism by Bessire, Andrew J, Subramanyam, Chakrapani

“…A critical component of antibody-drug conjugate (ADC) development is identification or verification of the active released entity upon cellular uptake and…”
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Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948 by Filipski, Kevin J., Martinez-Alsina, Luis A., Reese, Matthew R., Evrard, Edelweiss, Buzon, Leanne M., Cameron, Kimberly O., Zhang, Yuan, Coffman, Karen J., Bradow, James, Kormos, Bethany L., Liu, Shenping, Knafels, John D., Sahasrabudhe, Parag V., Chen, Jie, Kalgutkar, Amit S., Bessire, Andrew J., Orozco, Christine C., Balesano, Amanda, Cerny, Matthew A., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Rosado, Amy, Williams, George, Marshall, Mackenzie, Tam Neale, Kelly, Chen, Xian, Hirenallur-Shanthappa, Dinesh, Stansfield, John C., Groarke, John, Qiu, Ruolun, Karas, Spinel, Roth Flach, Rachel J., Esler, William P.

“…Inhibition of branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK), a negative regulator of branched-chain amino acid (BCAA) metabolism, is hypothesized…”
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Determination of Antibody–Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation by Bessire, Andrew J, Ballard, T. Eric, Charati, Manoj, Cohen, Justin, Green, Michael, Lam, My-Hanh, Loganzo, Frank, Nolting, Birte, Pierce, Betsy, Puthenveetil, Sujiet, Roberts, Lee, Schildknegt, Klaas, Subramanyam, Chakrapani

“…Antibody-drug conjugates (ADC) are currently an active area of research, focused primarily on oncology therapeutics, but also to a limited extent on other…”
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Development of Fluorophore-Labeled Thailanstatin Antibody-Drug Conjugates for Cellular Trafficking Studies by Kulkarni, Chethana, Finley, James E, Bessire, Andrew J, Zhong, Xiaotian, Musto, Sylvia, Graziani, Edmund I

“…As the antibody-drug conjugate (ADC) field grows increasingly important for cancer treatment, it is vital for researchers to establish a firm understanding of…”
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Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism by Tumey, L. Nathan, Leverett, Carolyn A, Vetelino, Beth, Li, Fengping, Rago, Brian, Han, Xiaogang, Loganzo, Frank, Musto, Sylvia, Bai, Guoyun, Sukuru, Sai Chetan K, Graziani, Edmund I, Puthenveetil, Sujiet, Casavant, Jeffrey, Ratnayake, Anokha, Marquette, Kimberly, Hudson, Sarah, Doppalapudi, Venkata Ramana, Stock, Joseph, Tchistiakova, Lioudmila, Bessire, Andrew J, Clark, Tracey, Lucas, Judy, Hosselet, Christine, O’Donnell, Christopher J, Subramanyam, Chakrapani

“…As part of our efforts to develop new classes of tubulin inhibitor payloads for antibody–drug conjugate (ADC) programs, we developed a tubulysin ADC that…”
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Dirlotapide as a model substrate to refine structure-based drug design strategies on CYP3A4-catalyzed metabolism by Sun, Hao, Bessire, Andrew J., Vaz, Alfin

“…Multiple crystal structures of CYP3A4 bound with various substrates or inhibitors have been used as templates for docking of new chemical entities to predict…”
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Nonclinical characterization of the pharmacokinetics and disposition of inotuzumab ozogamicin, a calicheamicin-containing antibody-drug conjugate by Johnson, Theodore R., Bessire, Andrew J., Gleave, Michelle, Nedderman, Angus N.R., Kavosi, Mania, Ballard, T. Eric

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Deconstruction of Activity-Dependent Covalent Modification of Heme in Human Neutrophil Myeloperoxidase by Multistage Mass Spectrometry (MS4) by Geoghegan, Kieran F, Varghese, Alison H, Feng, Xidong, Bessire, Andrew J, Conboy, James J, Ruggeri, Roger B, Ahn, Kay, Spath, Samantha N, Filippov, Sergey V, Conrad, Steven J, Carpino, Philip A, Guimarães, Cristiano R. W, Vajdos, Felix F

“…Myeloperoxidase (MPO) is known to be inactivated and covalently modified by treatment with hydrogen peroxide and agents similar to…”
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A rapid and specific derivatization procedure to identify acyl-glucuronides by mass spectrometry by Vaz, Alfin D. N., Wang, Wei Wei, Bessire, Andrew J., Sharma, Raman, Hagen, Anne E.

“…A simple procedure is described to identify acyl‐glucuronides by coupled liquid chromatography/mass spectrometry after derivatization to a hydroxamic acid with…”
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Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide by Robinson, Ralph P., Bartlett, Jeremy A., Bertinato, Peter, Bessire, Andrew J., Cosgrove, Judith, Foley, Patrick M., Manion, Tara B., Minich, Martha L., Ramos, Brenda, Reese, Matthew R., Schmahai, Theodore J., Swick, Andrew G., Tess, David A., Vaz, Alfin, Wolford, Angela

“…Analogues related to dirlotapide ( 1), a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) were prepared with the goal of further…”
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The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites by Bessire, Andrew J., Vaz, Alfin D. N., Walker, Gregory S., Wang, Wei Wei, Sharma, Raman

“…Oxidation of N‐alkyl‐substituted amides is a common transformation observed in metabolism studies of drugs and other chemicals. Metabolism at the alpha carbon…”
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Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease by Weng, Yan, Fonseca, Kari R., Bi, Yi-an, Mathialagan, Sumathy, Riccardi, Keith, Tseng, Elaine, Bessire, Andrew J., Cerny, Mathew A., Tess, David A., Rodrigues, A. David, Kalgutkar, Amit S., Litchfield, John, Di, Li, Varma, Manthena V. S.

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A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes by Ballard, T. Eric, Dahal, Upendra P., Bessire, Andrew J., Schneider, Richard P., Geoghegan, Kieran F., Vaz, Alfin D. N.

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Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease by Weng, Yan, Fonseca, Kari R, Bi, Yi-An, Mathialagan, Sumathy, Riccardi, Keith, Tseng, Elaine, Bessire, Andrew J, Cerny, Matthew A, Tess, David A, Rodrigues, A David, Kalgutkar, Amit S, Litchfield, John E, Di, Li, Varma, Manthena V S

“…Excess dietary fructose consumption promotes metabolic dysfunction thereby increasing the risk of obesity, type 2 diabetes, non-alcoholic steatohepatitis…”
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Linkage Isomerization Equilibria in (Chloranilato)palladium(II) Complexes with Amine Ligands. Crystal Structure of (Chloranilato)bis(acetonitrile)palladium(II) by Bessire, Andrew J, Whittlesey, Bruce R, Holwerda, Robert A

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The use of 18 O‐exchange and base‐catalyzed N ‐dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites by Bessire, Andrew J., Vaz, Alfin D. N., Walker, Gregory S., Wang, Wei Wei, Sharma, Raman

“…Abstract Oxidation of N ‐alkyl‐substituted amides is a common transformation observed in metabolism studies of drugs and other chemicals. Metabolism at the…”
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