Search Results - "Bessette, Paul H"

Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index by Desnoyers, Luc R, Vasiljeva, Olga, Richardson, Jennifer H, Yang, Annie, Menendez, Elizabeth E M, Liang, Tony W, Wong, Chihunt, Bessette, Paul H, Kamath, Kathy, Moore, Stephen J, Sagert, Jason G, Hostetter, Daniel R, Han, Fei, Gee, Jason, Flandez, Jeanne, Markham, Kate, Nguyen, Margaret, Krimm, Michael, Wong, Kenneth R, Liu, Shouchun, Daugherty, Patrick S, West, James W, Lowman, Henry B

“…Target-mediated toxicity constitutes a major limitation for the development of therapeutic antibodies. To redirect the activity of antibodies recognizing…”
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Marker-Specific Sorting of Rare Cells Using Dielectrophoresis by Xiaoyuan Hu, Paul H. Bessette, Jiangrong Qian, Carl D. Meinhart, Daugherty, Patrick S., Hyongsok T. Soh, Heeger, Alan J.

“…Current techniques in high-speed cell sorting are limited by the inherent coupling among three competing parameters of performance: throughput purity, and rare…”
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Efficient Folding of Proteins with Multiple Disulfide Bonds in the Escherichia coli Cytoplasm by Bassette, Paul H., Åslund, Fredrik, Beckwith, Jon, Georgiou, George

“…Under physiological conditions, the Escherichia coli cytoplasm is maintained in a reduced state that strongly disfavors the formation of stable disulfide bonds…”
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Rapid isolation of high-affinity protein binding peptides using bacterial display by Bessette, Paul H., Rice, Jeffrey J., Daugherty, Patrick S.

“…A robust bacterial display methodology was developed that allows the rapid isolation of peptides that bind to arbitrarily selected targets with high affinity…”
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Bacterial display using circularly permuted outer membrane protein OmpX yields high affinity peptide ligands by Rice, Jeffrey J., Schohn, Aaron, Bessette, Paul H., Boulware, Kevin T., Daugherty, Patrick S.

“…A bacterial display methodology was developed for N‐ and C‐terminal display and demonstrated to enable rapid screening of very large peptide libraries with…”
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Microfluidic Library Screening for Mapping Antibody Epitopes by Bessette, Paul H, Hu, Xiaoyuan, Soh, Hyongsok T, Daugherty, Patrick S

“…The capability to screen molecular libraries using disposable microfluidic devices provides the potential to simplify and automate reagent generation and to…”
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A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism by Trotta, Eleonora, Bessette, Paul H., Silveria, Stephanie L., Ely, Lauren K., Jude, Kevin M., Le, Duy T., Holst, Charles R., Coyle, Anthony, Potempa, Marc, Lanier, Lewis L., Garcia, K. Christopher, Crellin, Natasha K., Rondon, Isaac J., Bluestone, Jeffrey A.

“…Interleukin-2 (IL-2) has been shown to suppress immune pathologies by preferentially expanding regulatory T cells (T regs ). However, this therapy has been…”
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Enzymatic Synthesis of Layered Titanium Phosphates at Low Temperature and Neutral pH by Cell-Surface Display of Silicatein-α by Curnow, Paul, Bessette, Paul H, Kisailus, David, Murr, Meredith M, Daugherty, Patrick S, Morse, Daniel E

“…We introduce a novel method of inorganic synthesis using the catalytic and structure-directing properties of the demosponge enzyme silicatein-α. Recombinant…”
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Flow Cytometric Screening of cDNA Expression Libraries for Fluorescent Proteins by Bessette, Paul H., Daugherty, Patrick S.

“…Fluorescence‐activated cell sorting (FACS) was applied for quantitative screening of cDNA expression libraries in bacteria for rare fluorescent protein…”
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Effect of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide proteins in Escherichia coli by Bessette, P H, Qiu, J, Bardwell, J C, Swartz, J R, Georgiou, G

“…We have examined the role of the active-site CXXC central dipeptides of DsbA and DsbC in disulfide bond formation and isomerization in the Escherichia coli…”
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In Vivo and in Vitro Function of theEscherichia coli Periplasmic Cysteine Oxidoreductase DsbG by Bessette, Paul H., Cotto, José J., Gilbert, Hiram F., Georgiou, George

“…We have characterized in vivo and in vitro the recently identified DsbG from Escherichia coli. In addition to sharing sequence homology with the thiol…”
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Discovery of a novel human anti-IL-2 antibody that potentiates Regulatory T cells by a structure-based mechanism by Trotta, Eleonora, Bessette, Paul H., Silveria, Stephanie L., Ely, Lauren K., Jude, Kevin, Holst, Charles R., Coyle, Anthony, Garcia, Christopher K., Crellin, Natasha K., Rondon, Isaac J., Bluestone, Jeffrey A.

“…Abstract Interleukin-2 (IL-2) has been shown to suppress immune pathologies by preferentially expanding regulatory T cells (Treg). However, this therapy has…”
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In vivo and in vitro function of the Escherichia coli periplasmic cysteine oxidoreductase DsbG by Bessette, P H, Cotto, J J, Gilbert, H F, Georgiou, G

“…We have characterized in vivo and in vitro the recently identified DsbG from Escherichia coli. In addition to sharing sequence homology with the thiol…”
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Construction of designed protein libraries using gene assembly mutagenesis by Bessette, Paul H, Mena, Marco A, Nguyen, Annalee W, Daugherty, Patrick S

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Effect of Sequences of the Active-Site Dipeptides of DsbA and DsbC on In Vivo Folding of Multidisulfide Proteins inEscherichia coli by Paul H. Bessette, Ji Qiu, James C. A. Bardwell, James R. Swartz, George Georgiou

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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