Search Results - "Bessen, Richard A"

Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays by Wilham, Jason M, Orrú, Christina D, Bessen, Richard A, Atarashi, Ryuichiro, Sano, Kazunori, Race, Brent, Meade-White, Kimberly D, Taubner, Lara M, Timmes, Andrew, Caughey, Byron

“…A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such…”
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Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype by Crowell, Jenna, Hughson, Andrew, Caughey, Byron, Bessen, Richard A

“…Phenotypic diversity in prion diseases can be specified by prion strains in which biological traits are propagated through an epigenetic mechanism mediated by…”
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Lesion of the olfactory epithelium accelerates prion neuroinvasion and disease onset when prion replication is restricted to neurons by Crowell, Jenna, Wiley, James A, Bessen, Richard A

“…Natural prion diseases of ruminants are moderately contagious and while the gastrointestinal tract is the primary site of prion agent entry, other mucosae may…”
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Role of the Lymphoreticular System in Prion Neuroinvasion from the Oral and Nasal Mucosa by BESSEN, Richard A, MARTINKA, Scott, KELLY, Jessica, GONZALEZ, Daniel

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Interspecies Transmission of Chronic Wasting Disease Prions to Squirrel Monkeys (Saimiri sciureus) by MARSH, Richard F, KINCAID, Anthony E, BESSEN, Richard A, BARTZ, Jason C

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Prion shedding from olfactory neurons into nasal secretions by Bessen, Richard A, Shearin, Harold, Martinka, Scott, Boharski, Ryan, Lowe, Diana, Wilham, Jason M, Caughey, Byron, Wiley, James A

“…This study investigated the role of prion infection of the olfactory mucosa in the shedding of prion infectivity into nasal secretions. Prion infection with…”
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Degradation of the disease-associated prion protein by a serine protease from lichens by Johnson, Christopher J, Bennett, James P, Biro, Steven M, Duque-Velasquez, Juan Camilo, Rodriguez, Cynthia M, Bessen, Richard A, Rocke, Tonie E

“…The disease-associated prion protein (PrP(TSE)), the probable etiological agent of the transmissible spongiform encephalopathies (TSEs), is resistant to…”
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Accelerated Shedding of Prions following Damage to the Olfactory Epithelium by Bessen, Richard A, Wilham, Jason M, Lowe, Diana, Watschke, Christopher P, Shearin, Harold, Martinka, Scott, Caughey, Byron, Wiley, James A

“…In this study, we investigated the role of damage to the nasal mucosa in the shedding of prions into nasal samples as a pathway for prion transmission. Here,…”
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Phenotypic Similarity of Transmissible Mink Encephalopathy in Cattle and L-type Bovine Spongiform Encephalopathy in a Mouse Model by Baron, Thierry, Bencsik, Anna, Biacabe, Anne-Gaëlle, Morignat, Eric, Bessen, Richard A.

“…Transmissible mink encepholapathy (TME) is a foodborne transmissible spongiform encephalopathy (TSE) of ranch-raised mink; infection with a ruminant TSE has…”
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Transmission of chronic wasting disease identifies a prion strain causing cachexia and heart infection in hamsters by Bessen, Richard A, Robinson, Cameron J, Seelig, Davis M, Watschke, Christopher P, Lowe, Diana, Shearin, Harold, Martinka, Scott, Babcock, Alex M

“…Chronic wasting disease (CWD) is an emerging prion disease of free-ranging and captive cervids in North America. In this study we established a rodent model…”
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Rapid Prion Neuroinvasion following Tongue Infection by Bartz, Jason C, Kincaid, Anthony E, Bessen, Richard A

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Prion Infection of Muscle Cells In Vitro by DLAKIC, Wendy M, GRIGG, Eric, BESSEN, Richard A

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Prion Infection of Oral and Nasal Mucosa by DEJOIA, Crista, MOREAUX, Brian, O'CONNELL, Kimberly, BESSEN, Richard A

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Extraneural Prion Neuroinvasion without Lymphoreticular System Infection by BARTZ, Jason C, DEJOIA, Crista, TUCKER, Tammy, KINCAID, Anthony E, BESSEN, Richard A

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Prion Interference Is Due to a Reduction in Strain-Specific PrPSc Levels by BARTZ, Jason C, KRAMER, Michelle L, SHEEHAN, Meghan H, HUTTER, Jessica A. L, AYERS, Jacob I, BESSEN, Richard A, KINCAID, Anthony E

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Axonal and transynaptic spread of prions by Shearin, Harold, Bessen, Richard A

“…Natural transmission of prion diseases depends upon the spread of prions from the nervous system to excretory or secretory tissues, but the mechanism of prion…”
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Non-genetic propagation of strain-specific properties of scrapie prion protein by Bessen, Richard A, Kocisko, David A, Raymond, Gregory J, Nandan, Santosh, Lansbury, Peter T, Caughey, Byron

“…The infectious agents causing scrapie and other transmissible spongiform encephalopathies have been postulated to consist solely of the protease-resistant form…”
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Prion Infection of Skeletal Muscle Cells and Papillae in the Tongue by MULCAHY, Ellyn R, BARTZ, Jason C, KINCAID, Anthony E, BESSEN, Richard A

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Retrograde Transport of Transmissible Mink Encephalopathy within Descending Motor Tracts by Bartz, Jason C, Kincaid, Anthony E, Bessen, Richard A

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The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis by Parrie, Lindsay E., Crowell, Jenna A.E., Telling, Glenn C., Bessen, Richard A.

“…The cellular prion protein (PrPC) has been associated with diverse biological processes including cell signaling, neurogenesis, and neuroprotection, but its…”
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