Search Results - "Bessems, Jos"

The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data − a case study with caffeine by Bessems, Jos G.M, Paini, Alicia, Gajewska, Monika, Worth, Andrew

“…Highlights • The concept of Margin of Internal Exposure (MOIE) is proposed for route-to-route extrapolation. • It is an extension of the Margin of Exposure…”
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Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches by Coecke, Sandra, Pelkonen, Olavi, Leite, Sofia Batista, Bernauer, Ulrike, Bessems, Jos GM, Bois, Frederic Y., Gundert-Remy, Ursula, Loizou, George, Testai, Emanuela, Zaldívar, José-Manuel

“…► Toxicokinetics (TK) is a key element to integrate the results from in silico, in vitro and in vivo studies. ► TK is needed to estimate target organ doses…”
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Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles by de Jong, Esther, Barenys, Marta, Hermsen, Sanne A.B., Verhoef, Aart, Ossendorp, Bernadette C., Bessems, Jos G.M., Piersma, Aldert H.

“…The relatively high experimental animal use in developmental toxicity testing has stimulated the search for alternatives that are less animal intensive. Three…”
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PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop by Bessems, Jos G, Loizou, George, Krishnan, Kannan, Clewell, 3rd, Harvey J, Bernasconi, Camilla, Bois, Frederic, Coecke, Sandra, Collnot, Eva-Maria, Diembeck, Walter, Farcal, Lucian Romeo, Geraets, Liesbeth, Gundert-Remy, Ursula, Kramer, Nynke, Küsters, Gabriele, Leite, Sofia B, Pelkonen, Olavi R, Schröder, Klaus, Testai, Emanuela, Wilk-Zasadna, Iwona, Zaldívar-Comenges, José-Manuel

“…Information on toxicokinetics is critical for animal-free human risk assessment. Human external exposure must be translated into human tissue doses and…”
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Proper knowledge on toxicokinetics improves human hazard testing and subsequent health risk characterisation. A case study approach by Bessems, Jos G.M., Geraets, Liesbeth

“…•Requirements on ADME/TK are inconsistent within EU legislative frameworks on chemicals safety.•Regulatory risk assessors from various EU chemicals frameworks…”
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The methodology of quantitative risk assessment studies by Rigaud, Maxime, Buekers, Jurgen, Bessems, Jos, Basagaña, Xavier, Mathy, Sandrine, Nieuwenhuijsen, Mark, Slama, Rémy

“…Once an external factor has been deemed likely to influence human health and a dose response function is available, an assessment of its health impact or that…”
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Towards a systematic use of effect biomarkers in population and occupational biomonitoring by Zare Jeddi, Maryam, Hopf, Nancy B., Viegas, Susana, Price, Anna Bal, Paini, Alicia, van Thriel, Christoph, Benfenati, Emilio, Ndaw, Sophie, Bessems, Jos, Behnisch, Peter A., Leng, Gabriele, Duca, Radu-Corneliu, Verhagen, Hans, Cubadda, Francesco, Brennan, Lorraine, Ali, Imran, David, Arthur, Mustieles, Vicente, Fernandez, Mariana F., Louro, Henriqueta, Pasanen-Kase, Robert

“…•Reliable effect biomarkers are available for most of the relevant MoAs.•Increasing AOP knowledge fosters the use of effect biomarkers in regulatory…”
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The European exposure science strategy 2020–2030 by Fantke, Peter, Bruinen de Bruin, Yuri, Schlüter, Urs, Connolly, Alison, Bessems, Jos, Kephalopoulos, Stylianos, Zare Jeddi, Maryam, van Nieuwenhuyse, An, Dudzina, Tatsiana, Scheepers, Paul T.J., von Goetz, Natalie

“…[Display omitted] Exposure science is an emerging and rapidly growing field dedicated to all aspects concerning the contact between chemical, biological,…”
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Developing human biomonitoring as a 21st century toolbox within the European exposure science strategy 2020–2030 by Zare Jeddi, Maryam, Hopf, Nancy B., Louro, Henriqueta, Viegas, Susana, Galea, Karen S., Pasanen-Kase, Robert, Santonen, Tiina, Mustieles, Vicente, Fernandez, Mariana F., Verhagen, Hans, Bopp, Stephanie K., Antignac, Jean Philippe, David, Arthur, Mol, Hans, Barouki, Robert, Audouze, Karine, Duca, Radu-Corneliu, Fantke, Peter, Scheepers, Paul, Ghosh, Manosij, Van Nieuwenhuyse, An, Lobo Vicente, Joana, Trier, Xenia, Rambaud, Loïc, Fillol, Clémence, Denys, Sebastien, Conrad, André, Kolossa-Gehring, Marike, Paini, Alicia, Arnot, Jon, Schulze, Florian, Jones, Kate, Sepai, Ovnair, Ali, Imran, Brennan, Lorraine, Benfenati, Emilio, Cubadda, Francesco, Mantovani, Alberto, Bartonova, Alena, Connolly, Alison, Slobodnik, Jaroslav, Bruinen de Bruin, Yuri, van Klaveren, Jacob, Palmen, Nicole, Dirven, Hubert, Husøy, Trine, Thomsen, Cathrine, Virgolino, Ana, Röösli, Martin, Gant, Tim, von Goetz, Natalie, Bessems, Jos

“…Human biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission’s Chemicals Strategy for Sustainability…”
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Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010 by Adler, Sarah, Basketter, David, Creton, Stuart, Pelkonen, Olavi, van Benthem, Jan, Zuang, Valérie, Andersen, Klaus Ejner, Angers-Loustau, Alexandre, Aptula, Aynur, Bal-Price, Anna, Benfenati, Emilio, Bernauer, Ulrike, Bessems, Jos, Bois, Frederic Y., Boobis, Alan, Brandon, Esther, Bremer, Susanne, Broschard, Thomas, Casati, Silvia, Coecke, Sandra, Corvi, Raffaella, Cronin, Mark, Daston, George, Dekant, Wolfgang, Felter, Susan, Grignard, Elise, Gundert-Remy, Ursula, Heinonen, Tuula, Kimber, Ian, Kleinjans, Jos, Komulainen, Hannu, Kreiling, Reinhard, Kreysa, Joachim, Leite, Sofia Batista, Loizou, George, Maxwell, Gavin, Mazzatorta, Paolo, Munn, Sharon, Pfuhler, Stefan, Phrakonkham, Pascal, Piersma, Aldert, Poth, Albrecht, Prieto, Pilar, Repetto, Guillermo, Rogiers, Vera, Schoeters, Greet, Schwarz, Michael, Serafimova, Rositsa, Tähti, Hanna, Testai, Emanuela, van Delft, Joost, van Loveren, Henk, Vinken, Mathieu, Worth, Andrew, Zaldivar, José-Manuel

“…The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics on the market in Europe after 2013. In that context, the European…”
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Human risk assessment of dermal and inhalation exposures to chemicals assessed by route-to-route extrapolation: The necessity of kinetic data by Geraets, Liesbeth, Bessems, Jos G.M., Zeilmaker, Marco J., Bos, Peter M.J.

“…•Risk assessment for dermal or inhalation exposure often relies on route-to-route extrapolation.•For an adequate route-to-route extrapolation availability of…”
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A harmonized occupational biomonitoring approach by Hopf, Nancy B., Rousselle, Christophe, Poddalgoda, Devika, Lamkarkach, Farida, Bessems, Jos, Schmid, Kaspar, Jones, Kate, Takaki, Koki, Casteleyn, Ludwine, Zare Jeddi, Maryam, Bader, Michael, Koller, Michael, Browne, Patience, FitzGerald, Rex, Viegas, Susana, Göen, Thomas, Santonen, Tiina, Väänänen, Virpi, Duca, Radu - Corneliu, Pasanen-Kase, Robert

“…•International Collaboration between 15 countries to derive a Biomonitoring guidance.•Step-by-step approach for health professionals deriving biomonitoring…”
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Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment by Reale, Elena, Zare Jeddi, Maryam, Paini, Alicia, Connolly, Alison, Duca, Radu, Cubadda, Francesco, Benfenati, Emilio, Bessems, Jos, S. Galea, Karen, Dirven, Hubert, Santonen, Tiina, M. Koch, Holger, Jones, Kate, Sams, Craig, Viegas, Susana, Kyriaki, Machera, Campisi, Luca, David, Arthur, Antignac, Jean-Philippe, B Hopf, Nancy

“…Human health risk assessment is historically built upon animal testing, often following Organisation for Economic Co-operation and Development (OECD) test…”
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A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring by Purece, Anthony, Thomsen, Sofie Theresa, Plass, Dietrich, Spyropoulou, Anastasia, Machera, Kyriaki, Palmont, Philippe, Crépet, Amélie, Benchrih, Rafiqa, Devleesschauwer, Brecht, Wieland, Nina, Scheepers, Paul, Deepika, Deepika, Kumar, Vikas, Sanchez, Gerardo, Bessems, Jos, Piselli, Dario, Buekers, Jurgen

“…Human biomonitoring (HBM) data indicate that exposure to pyrethroids is widespread in Europe, with significantly higher exposure observed in children compared…”
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Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches by Bessems, Jos G. M., Vermeulen, Nico P. E.

“…An overview is presented on the molecular aspects of toxicity due to paracetamol (acetaminophen) and structural analogues. The emphasis is on four main topics,…”
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Building a European exposure science strategy by Fantke, Peter, von Goetz, Natalie, Schlüter, Urs, Bessems, Jos, Connolly, Alison, Dudzina, Tatsiana, Ahrens, Andreas, Bridges, Jim, Coggins, Marie A., Conrad, André, Hänninen, Otto, Heinemeyer, Gerhard, Kephalopoulos, Stylianos, McLachlan, Michael, Meijster, Tim, Poulsen, Veronique, Rother, Dag, Vermeire, Theo, Viegas, Susana, Vlaanderen, Jelle, Jeddi, Maryam Zare, Bruinen de Bruin, Yuri

“…Exposure information is a critical element in various regulatory and non-regulatory frameworks in Europe and elsewhere. Exposure science supports to ensure…”
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Quantitative Extrapolation of In Vitro Whole Embryo Culture Embryotoxicity Data to Developmental Toxicity In Vivo Using the Benchmark Dose Approach by Piersma, Aldert H., Janer, Gemma, Wolterink, Gerrit, Bessems, Jos G. M., Hakkert, Betty C., Slob, Wout

“…If in vitro data are to be used as a basis for hazard characterization, a translation of an in vitro concentration toward an in vivo dose must be made. In this…”
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Glyphosate and AMPA in Human Urine of HBM4EU Aligned Studies: Part A Children by Buekers, Jurgen, Remy, Sylvie, Bessems, Jos, Govarts, Eva, Rambaud, Loïc, Riou, Margaux, Tratnik, Janja Snoj, Stajnko, Anja, Katsonouri, Andromachi, Makris, Konstantinos C, De Decker, Annelies, Morrens, Bert, Vogel, Nina, Kolossa-Gehring, Marike, Esteban-López, Marta, Castaño, Argelia, Andersen, Helle Raun, Schoeters, Greet

“…Few data are available on the exposure of children to glyphosate (Gly) in Europe. Within HBM4EU, new HBM exposure data were collected from aligned studies at…”
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Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults by Buekers, Jurgen, Remy, Sylvie, Bessems, Jos, Govarts, Eva, Rambaud, Loïc, Riou, Margaux, Halldorsson, Thorhallur I, Ólafsdóttir, Kristin, Probst-Hensch, Nicole, Ammann, Priska, Weber, Till, Kolossa-Gehring, Marike, Esteban-López, Marta, Castaño, Argelia, Andersen, Helle Raun, Schoeters, Greet

“…Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult…”
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Application of toxicogenomics in hepatic systems toxicology for risk assessment: Acetaminophen as a case study by Kienhuis, Anne S., Bessems, Jos G.M., Pennings, Jeroen L.A., Driessen, Marja, Luijten, Mirjam, van Delft, Joost H.M., Peijnenburg, Ad A.C.M., der Ven, Leo T.M. van

“…Hepatic systems toxicology is the integrative analysis of toxicogenomic technologies, e.g., transcriptomics, proteomics, and metabolomics, in combination with…”
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