Search Results - "Bessa, Paraskevi"
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Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140
Published in Neuron (Cambridge, Mass.) (05-12-2018)“…The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3…”
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Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring
Published in Nature communications (16-08-2024)“…Disruption of neocortical circuitry and architecture in humans causes numerous neurodevelopmental disorders. Neocortical cytoarchitecture is orchestrated by…”
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Molecular mechanisms of corpus callosum development: a four-step journey
Published in Frontiers in neuroanatomy (17-01-2024)“…The Corpus Callosum (CC) is a bundle of axons connecting the cerebral hemispheres. It is the most recent structure to have appeared during evolution of…”
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Satb2 Cre/+ mouse as a tool to investigate cell fate determination in the developing neocortex
Published in Journal of neuroscience methods (01-11-2017)“…Generation of different neuronal subtypes during neocortical development is the most important step in the establishment of cortical cytoarchitecture. The…”
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CDK5RAP2 Is Required to Maintain the Germ Cell Pool during Embryonic Development
Published in Stem cell reports (14-02-2017)“…Gene products linked to microcephaly have been studied foremost for their role in brain development, while their function in the development of other organs…”
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TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6
Published in Cerebral cortex (New York, N.Y. 1991) (20-02-2023)“…Abstract Abnormal development of corpus callosum is relatively common and causes a broad spectrum of cognitive impairments in humans. We use acallosal…”
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Activity‐ DEP endent Transposition
Published in EMBO reports (01-03-2017)Get full text
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Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression
Published in Nucleic acids research (27-10-2023)“…Abstract The seat of higher-order cognitive abilities in mammals, the neocortex, is a complex structure, organized in several layers. The different subtypes of…”
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TrkC-T1, the Non-Catalytic Isoform of TrkC, Governs Neocortical Progenitor Fate Specification by Inhibition of MAP Kinase Signaling
Published in Cerebral cortex (New York, N.Y. 1991) (22-10-2021)“…Abstract Neocortical projection neurons are generated by neural progenitor cells (NPCs) within the ventricular and subventricular zone. While early NPCs can…”
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10
Activity‐DEPendent Transposition
Published in EMBO reports (01-03-2017)“…Graphical Abstract The authors propose a novel mechanism, termed Activity‐DEPendent Transpositon (ADEPT), in which epigenetic drift and the preferential use of…”
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Expanding the phenotype of NUP85 mutations beyond nephrotic syndrome to primary autosomal recessive microcephaly and Seckel syndrome spectrum disorders
Published in Human molecular genetics (15-11-2021)“…Abstract Primary autosomal recessive microcephaly and Seckel syndrome spectrum disorders (MCPH–SCKS) include a heterogeneous group of autosomal recessive…”
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Satb2Cre/+ mouse as a tool to investigate cell fate determination in the developing neocortex
Published in Journal of neuroscience methods (01-11-2017)“…[Display omitted] •Satb2Cre/+ mouse can be applied to study cell fate acquisition.•The generation of deeper and upper layer neurons is fundamental for the…”
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