Therapeutic Effects of Bacteroides fragilis Vesicles in a Model of Chemically Induced Colitis in Rats

Therapeutic Effects of Bacteroides fragilis Vesicles in a Model of Chemically Induced Colitis in Rats

The anti-inflammatory properties of Bacteroides fragilis vesicles were studied in a rat model of dextran sodium sulfate-induced colitis. According to the histology results, addition of B. fragilis vesicles to the therapy promoted colon repair. Evaluation of the disease activity index confirms the hi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 177; no. 5; pp. 626 - 629
Main Authors: Shagaleeva, O. Yu, Kashatnikova, D. A., Vorobyeva, E. A., Kardonsky, D. A., Silantiev, A. S., Efimov, B. A., Ivanov, V. A., Bespyatikh, Yu. A., Zakharzhevskaya, N. B.
Format: Journal Article
Language:English
Published: New York Springer US 01-09-2024
Springer Nature B.V
Subjects:
Abscesses
Animals
Anti-inflammatory agents
Bacteroides fragilis
Biomedical and Life Sciences
Biomedicine
Body weight
Cell Biology
Colitis
Colitis - chemically induced
Colitis - drug therapy
Colitis - microbiology
Colitis - pathology
Colon
Colon - drug effects
Colon - microbiology
Colon - pathology
Dextran
Dextran Sulfate - toxicity
Disease
Disease Models, Animal
Drinking water
Histology
Inflammatory bowel disease
Internal Medicine
Laboratory animals
Laboratory Medicine
Male
Medical research
Microscopy
Pathology
Pharmacology and Toxicology
Rats
Rats, Wistar
Sodium sulfate
Toxicology
Vesicles
rats
inflammatory bowel diseases
Bacteroides fragilis
dextran sulfate sodium
vesicles
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Description
Summary:The anti-inflammatory properties of Bacteroides fragilis vesicles were studied in a rat model of dextran sodium sulfate-induced colitis. According to the histology results, addition of B. fragilis vesicles to the therapy promoted colon repair. Evaluation of the disease activity index confirms the high rate of colon recovery: against the background of vesicle administration, the absence of blood in stool, normal stool consistency, and body weight normalization were observed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06237-2