Search Results - "Bespalov, Anton Y."

Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain? by Marek, Gerard J, Behl, Berthold, Bespalov, Anton Y, Gross, Gerhard, Lee, Younglim, Schoemaker, Hans

“…Dopamine D2 receptor blockade has been an obligate mechanism of action present in all medications that effectively treat positive symptoms of schizophrenia…”
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Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats by Pietraszek, Małgorzata, Sukhanov, Ilia, Maciejak, Piotr, Szyndler, Janusz, Gravius, Andreas, Wisłowska, Aleksandra, Płaźnik, Adam, Bespalov, Anton Y., Danysz, Wojciech

“…The purpose of the present study was to compare anxiolytic activity of the metabotropic glutamate receptor 1 (mGlu) antagonist, EMQMCM…”
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Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression by Bespalov, Anton Y., van Gaalen, Marcel M., Sukhotina, Irina A., Wicke, Karsten, Mezler, Mario, Schoemaker, Hans, Gross, Gerhard

“…There is a growing body of evidence indicating that stimulation of metabotropic glutamate type II receptors (mGlu 2/3) reduces anxiety in laboratory animals…”
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Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats by Bespalov, Anton Y., Dravolina, Olga A., Sukhanov, Ilya, Zakharova, Elena, Blokhina, Elena, Zvartau, Edwin, Danysz, Wojciech, van Heeke, Gino, Markou, Athina

“…Previous studies suggested that metabotropic glutamate 5 (mGlu5) receptors play an important role in the reinforcing effects of abused drugs. The present…”
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Clusterization of Behavioral and Psychological Symptoms of Dementia as Assessed by Neuropsychiatric Inventory: A Case Against the Use of Principal Component Analysis by Galankin, Timofey L, Bespalov, Anton Y, Moebius, Hans Y

“…The term Behavioral and Psychological Symptoms of Dementia (BPSD) covers a group of phenomenologically and medically distinct symptoms that rarely occur in…”
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Efficacy and side effects of baclofen and the novel GABA B receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction by Vengeliene, Valentina, Takahashi, Tatiane T, Dravolina, Olga A, Belozertseva, Irina, Zvartau, Edwin, Bespalov, Anton Y, Spanagel, Rainer

“…Preclinical studies suggest that the GABA receptor is a potential target for treatment of substance use disorders. However, recent clinical trials report…”
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mGlu1 receptor as a drug target for treatment of substance use disorders: time to gather stones together? by Dravolina, Olga A., Zvartau, Edwin, Danysz, Wojciech, Bespalov, Anton Y.

“…Modulation of the mGlu1 receptor was repeatedly shown to inhibit various phenomena associated with exposure to abused drugs. Efficacy in preclinical models was…”
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Agonist and antagonist effects of cytisine in vivo by Radchenko, Elena V., Dravolina, Olga A., Bespalov, Anton Y.

“…Varenicline, the most successful smoking cessation aid, is a selective partial agonists at α4β2* nicotinic receptors. Its efficacy is likely to be shared by…”
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Efficacy and side effects of baclofen and the novel GABAB receptor positive allosteric modulator CMPPE in animal models for alcohol and cocaine addiction by Vengeliene, Valentina, Takahashi, Tatiane T., Dravolina, Olga A., Belozertseva, Irina, Zvartau, Edwin, Bespalov, Anton Y., Spanagel, Rainer

“…Rationale Preclinical studies suggest that the GABA B receptor is a potential target for treatment of substance use disorders. However, recent clinical trials…”
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Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies by Hillen, Heinz, Barghorn, Stefan, Striebinger, Andreas, Labkovsky, Boris, Müller, Reinhold, Nimmrich, Volker, Nolte, Marc W, Perez-Cruz, Claudia, van der Auwera, Ingrid, van Leuven, Fred, van Gaalen, Marcel, Bespalov, Anton Y, Schoemaker, Hans, Sullivan, James P, Ebert, Ulrich

“…Oligomers of the beta-amyloid (Abeta) peptide have been indicated in early neuropathologic changes in Alzheimer's disease. Here, we present a synthetic…”
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mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in rats by Dravolina, Olga A., Zakharova, Elena S., Shekunova, Elena V., Zvartau, Edwin E., Danysz, Wojciech, Bespalov, Anton Y.

“…Glutamatergic neurotransmission is believed to be critically involved in the acquisition and maintenance of drug addiction. The present study evaluated the…”
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Effects of group I metabotropic glutamate receptor antagonists on the behavioral sensitization to motor effects of cocaine in rats by DRAVOLINA, Olga A, DANYSZ, Wojciech, BESPALOV, Anton Y

“…Metabotropic glutamate receptors (mGluRs) were reported to regulate various behavioral effects of addictive drugs. The present study evaluated the role of…”
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Antinociceptive activity of combination of morphine and NMDA receptor antagonists depends on the inter-injection interval by Belozertseva, Irina V, Dravolina, Olga A, Neznanova, Olga N, Danysz, Wojciech, Bespalov, Anton Y

“…The actual time-course of morphine antinociception is shorter than what would be predicted from its elimination kinetics, suggesting the presence of an acute…”
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Effects of mGlu1 receptor blockade on working memory, time estimation, and impulsivity in rats by Sukhotina, Irina A., Dravolina, Olga A., Novitskaya, Yulia, Zvartau, Edwin E., Danysz, Wojciech, Bespalov, Anton Y.

“…Rationale Metabotropic glutamate 1 (mGlu1) receptor antagonists were reported to induce cognitive deficits in several animal models using aversive learning…”
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Analgesic effects of morphine and loperamide in the rat formalin test: Interactions with NMDA receptor antagonists by Sevostianova, Natalja, Danysz, Wojciech, Bespalov, Anton Y.

“…To reveal peripheral components of opiate analgesia, effects of loperamide, opioid agonist which does not penetrate the blood–brain barrier, were examined in…”
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Effects of nicotinic and NMDA receptor channel blockers on intravenous cocaine and nicotine self-administration in mice by Blokhina, Elena A., Kashkin, Vladimir A., Zvartau, Edwin E., Danysz, Wojciech, Bespalov, Anton Y.

“…Previous studies have indicated that blockade of N-methyl- d-aspartate (NMDA) subtype of glutamate receptors prevents acquisition of instrumental behaviors…”
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Intravenous self-administration of abused solvents and anesthetics in mice by Blokhina, Elena A, Dravolina, Olga A, Bespalov, Anton Y, Balster, Robert L, Zvartau, Edwin E

“…Volatile organic solvents, fuels and anesthetics are subject to abuse. The aim of the present study was to evaluate i.v. self-administration of several of…”
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Estrous cycle stage-dependent expression of acute tolerance to morphine analgesia in rats by Shekunova, Elena V., Bespalov, Anton Y.

“…Both baseline pain sensitivity and the response to antinociceptive treatment are sensitive to an animal's sex and estrous cycle stage. Sex differences are also…”
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Effects of memantine on estrogen-dependent acute tolerance to the morphine analgesia in female rats by Shekunova, Elena V., Bespalov, Anton Y.

“…Both human and animal studies suggest that there are sex differences in responding to noxious stimulation as well as in effects of opiate analgesic drugs…”
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Antidepressant treatment in anxiety disorders by Bespalov, Anton Y, van Gaalen, Marcel M, Gross, Gerhard

“…Antidepressant drug treatment is the clinical standard of care for all types of anxiety disorders. Broad efficacy of selective serotonin reuptake inhibitors…”
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