Search Results - "Beshr, Eman"

Predicting soil cone index and assessing suitability for wind and solar farm development in using machine learning techniques by Hassan, Marwa, Beshr, Eman

“…This study proposes a novel approach that combines machine learning models to predict soil compaction using the soil cone index values. The methodology…”
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A Robust Strategy Based on Marine Predators Algorithm for Large Scale Photovoltaic Array Reconfiguration to Mitigate the Partial Shading Effect on the Performance of PV System by Yousri, Dalia, Babu, Thanikanti Sudhakar, Beshr, Eman, Eteiba, Magdy B., Allam, Dalia

“…Large-scale solar photovoltaic (PV) plants play an essential role in providing the increasing demand for energy in recent time. Therefore, in the purpose of…”
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Combination of an Oxindole Derivative with (-)-β-Elemene Alters Cell Death Pathways in FLT3/ITD + Acute Myeloid Leukemia Cells by Alanazi, Jowaher, Bender, Onur, Dogan, Rumeysa, Malik, Jonaid Ahmad, Atalay, Arzu, Ali, Taha F S, Beshr, Eman A M, Shawky, Ahmed M, Aly, Omar M, Alqahtani, Yasir Nasser H, Anwar, Sirajudheen

“…Acute myeloid leukemia (AML) is one of the cancers that grow most aggressively. The challenges in AML management are huge, despite many treatment options…”
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New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization by Ezelarab, Hend A. A., Ali, Taha F. S., Abbas, Samar H., Sayed, Ahmed M., Beshr, Eman A. M., Hassan, Heba A.

“…New 3-substituted oxindole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of compounds 6a–j was…”
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Emerging insights into pyrazoline motifs: A comprehensive exploration of biological mechanisms and prospects for future advancements by Abou-Zied, Hesham A., Beshr, Eman A.M., Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…•Review of therapeutic potential of pyrazolines.•Pyrazoline motifs: promising agents in disease treatment.•Inspiring pharmacotherapy avenues for…”
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New nitric oxide donating 1,2,4-triazole/oxime hybrids: Synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities by Abdel-Aziz, Mohamed, Abuo-Rahma, Gamal El-Din A.A., Beshr, Eman A.M., Ali, Taha F.S.

“…A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested…”
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Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation by Aboeldahab, Alshimaa M.A., Beshr, Eman A.M., Shoman, Mai E., Rabea, Safwat M., Aly, Omar M.

“…Two structurally novel series of histone deacetylase inhibitors (HDACIs) involving two potential surface recognition moieties;…”
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1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities by Abuo-Rahma, Gamal El-Din A.A., Abdel-Aziz, Mohamed, Beshr, Eman A.M., Ali, Taha F.S.

“…A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity and antiproliferative…”
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Design, synthesis, and molecular docking of novel pyrazole-chalcone analogs of lonazolac as 5-LOX, iNOS and tubulin polymerization inhibitors with potential anticancer and anti-inflammatory activities by Ahmed, Asmaa H.H., Mohamed, Mamdouh F.A., Allam, Rasha M., Nafady, Ayman, Mohamed, Shaaban K., Gouda, Ahmed E., Beshr, Eman A.M.

“…[Display omitted] •A novel series of pyrazole-chalcone analogues of lonazolac (7a-g and 8a-g) and screened for their in vitro anticancer activity.•Hybrid 8g…”
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Pyrrolizine/Indolizine-NSAID Hybrids: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies by Abourehab, Mohammed A S, Alqahtani, Alaa M, Almalki, Faisal A, Zaher, Dana M, Abdalla, Ashraf N, Gouda, Ahmed M, Beshr, Eman A M

“…In the current study, eight new hybrids of the NSAIDs, ibuprofen and ketoprofen with five pyrrolizine/indolizine derivatives were designed and synthesized. The…”
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Indole-based FLT3 inhibitors and related scaffolds as potential therapeutic agents for acute myeloid leukemia by Ezelarab, Hend A. A., Ali, Taha F. S., Abbas, Samar H., Hassan, Heba A., Beshr, Eman A. M.

“…Fms-like tyrosine kinase 3 (FLT3) mutation mechanisms are among the most common genetic abnormalities detected in about 30% of acute myeloid leukemia (AML)…”
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Discovery of oxindole‐based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation by Bender, Onur, Shoman, Mai E., Ali, Taha F. S., Dogan, Rumeysa, Celik, Ismail, Mollica, Adriano, Hamed, Mohammed I. A., Aly, Omar M., Alamri, Abdulwahab, Alanazi, Jowaher, Ahemad, Nafees, Gan, Siew Hua, Malik, Jonaid Ahmad, Anwar, Sirajudheen, Atalay, Arzu, Beshr, Eman A. M.

“…FMS‐like tyrosine kinase 3 (FLT3) mutations occur in approximately 30% of acute myeloid leukemia (AML) patients. In the current study, the oxindole chemotype…”
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Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition by Amin, Mohammed M., Abuo-Rahma, Gamal El-Din A., Shaykoon, Montaser Sh. A., Marzouk, Adel A., Abourehab, Mohammed A.S., Saraya, Roshdy E., Badr, Mohamed, Sayed, Ahmed M., Beshr, Eman A.M.

“…[Display omitted] •Thirteennovel 8-hydroxyquinoline-chalcone hybrids were designed and synthesized.•3d,3e, 3f, 3i,3k,and3lshowed effective inhibition against…”
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Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors by Rehuman, Nisha Abdul, Oh, Jong Min, Abdelgawad, Mohamed A, Beshr, Eman A M, Abourehab, Mohammed A S, Gambacorta, Nicola, Nicolotti, Orazio, Jat, Rakesh Kumar, Kim, Hoon, Mathew, Bijo

“…Two series of dimethoxy-halogenated chalcones (DM1−DM20) were synthesized and tested for their ability to inhibit monoamine oxidase (MAOs). Compound DM2…”
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New 1,3,4-oxadiazole/oxime hybrids: Design, synthesis, anti-inflammatory, COX inhibitory activities and ulcerogenic liability by Abd-Ellah, Heba S., Abdel-Aziz, Mohamed, Shoman, Mai E., Beshr, Eman A.M., Kaoud, TamerS, Ahmed, Al-Shaimaa F.F.

“…[Display omitted] •Synthesis of new 1,3,4-oxadiazole/nitric oxide hybrids.•Investigation of nitric oxide release.•Biological evaluation including…”
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Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAFV600E Inhibitory Pathways by Al-Wahaibi, Lamya H., Abou-Zied, Hesham A., Hisham, Mohamed, Beshr, Eman A. M., Youssif, Bahaa G. M., Bräse, Stefan, Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…A series of novel 3-cyanopyridone/pyrazoline hybrids (21–30) exhibiting dual inhibition against EGFR and BRAFV600E has been developed. The synthesized target…”
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New 2-oxoindole derivatives as multiple PDGFRα/ß and VEGFR-2 tyrosine kinase inhibitors by Ezelarab, Hend A.A., Abd El-Hafeez, Amer Ali, Ali, Taha F.S., Sayed, Ahmed M., Hassan, Heba A., Beshr, Eman A.M., Abbas, Samar H.

“…[Display omitted] •Two series based 2-oxoindole derivatives. N-aryl acetamides 6a-o having amide linker and its isoster benzyloxy benzylidenes 9a-p were…”
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A New Hybrid Technique for Minimizing Power Losses in a Distribution System by Optimal Sizing and Siting of Distributed Generators with Network Reconfiguration by Abd El-salam, Mirna, Beshr, Eman, Eteiba, Magdy

“…Transformations are taking place within the distribution systems to cope with the congestions and reliability concerns. This paper presents a new technique to…”
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Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors by Al-Wahaibi, Lamya H., Abou-Zied, Hesham A., Beshr, Eman A. M., Youssif, Bahaa G. M., Hayallah, Alaa M., Abdel-Aziz, Mohamed

“…Some new Bis-pyrazoline hybrids 8–17 with dual EGFR and BRAFV600E inhibitors have been developed. The target compounds were synthesized and tested in vitro…”
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HSP70 induction by bleomycin metal core analogs by Ali, Taha F.S., Taira, Naomi, Iwamaru, Kana, Koga, Ryoko, Kamo, Masahiro, Radwan, Mohamed O., Tateishi, Hiroshi, Kurosaki, Hiromasa, Abdel-Aziz, Mohamed, Abuo-Rahma, Gamal El-Din A.A., Beshr, Eman A.M., Otsuka, Masami, Fujita, Mikako

“…[Display omitted] Induction of heat shock protein 70 (HSP70) is known to be effective against various diseases. We are interested in HSP70 induction capability…”
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