Search Results - "Besharse Joseph C."

The Retina and Other Light-sensitive Ocular Clocks by Besharse, Joseph C., McMahon, Douglas G.

“…Ocular clocks, first identified in the retina, are also found in the retinal pigment epithelium (RPE), cornea, and ciliary body. The retina is a complex tissue…”
Get full text

Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors by Insinna, Christine, Besharse, Joseph C.

“…Analysis of the other segments of rod and cone photoreceptors in vertebrates has provided a rich molecular understanding of how light absorbed by a visual…”
Get full text

Yap and Taz regulate retinal pigment epithelial cell fate by Miesfeld, Joel B, Gestri, Gaia, Clark, Brian S, Flinn, Michael A, Poole, Richard J, Bader, Jason R, Besharse, Joseph C, Wilson, Stephen W, Link, Brian A

“…The optic vesicle comprises a pool of bi-potential progenitor cells from which the retinal pigment epithelium (RPE) and neural retina fates segregate during…”
Get full text

Ablation of mpeg+ Macrophages Exacerbates mfrp-Related Hyperopia by Brandt, Zachary J, Collery, Ross F, Besharse, Joseph C, Link, Brian A

“…Proper refractive development of the eye, termed emmetropization, is critical for focused vision and is impacted by both genetic determinants and several…”
Get full text

The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development by Insinna, Christine, Pathak, Narendra, Perkins, Brian, Drummond, Iain, Besharse, Joseph C.

“…Sensory cilia and intraflagellar transport (IFT), a pathway essential for ciliogenesis, play important roles in embryonic development and cell differentiation…”
Get full text

Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages by Collery, Ross F, Volberding, Peter J, Bostrom, Jonathan R, Link, Brian A, Besharse, Joseph C

“…Mutations in membrane frizzled-related protein (MFRP) are associated with nanophthalmia, hyperopia, foveoschisis, irregular patches of RPE atrophy, and optic…”
Get full text

Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity by Green, Carla B, Douris, Nicholas, Kojima, Shihoko, Strayer, Carl A, Fogerty, Joseph, Lourim, David, Keller, Susanna R, Besharse, Joseph C

“…The mammalian circadian system consists of a central oscillator in the suprachiasmatic nucleus of the hypothalamus, which coordinates peripheral clocks in…”
Get full text

Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms by Lewis, Tylor R., Kundinger, Sean R., Pavlovich, Amira L., Bostrom, Jonathan R., Link, Brian A., Besharse, Joseph C.

“…Zebrafish morphants of osm-3/kif17, a kinesin-2 family member and intraflagellar transport motor, have photoreceptor outer segments that are dramatically…”
Get full text

The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light by Scoma, Heather Dehlin, Humby, Monica, Yadav, Geetha, Zhang, Qingjiong, Fogerty, Joseph, Besharse, Joseph C

“…We have identified a novel component of the circadian clock that regulates its sensitivity to light at the evening light to dark transition. USP2 (Ubiquitin…”
Get full text

Different roles for KIF17 and kinesin II in photoreceptor development and maintenance by Insinna, Christine, Humby, Monica, Sedmak, Tina, Wolfrum, Uwe, Besharse, Joseph C.

“…Kinesin 2 family members are involved in transport along ciliary microtubules. In Caenorhabditis elegans channel cilia, kinesin II and OSM‐3 cooperate along…”
Get full text

Photoreceptor IFT Complexes Containing Chaperones, Guanylyl Cyclase 1 and Rhodopsin by Bhowmick, Reshma, Li, Mei, Sun, Jun, Baker, Sheila A, Insinna, Christine, Besharse, Joseph C

“…Intraflagellar transport (IFT) provides a mechanism for the transport of cilium-specific proteins, but the mechanisms for linkage of cargo and IFT proteins…”
Get full text

The Intraflagellar Transport Protein, IFT88, Is Essential for Vertebrate Photoreceptor Assembly and Maintenance by Pazour, Gregory J., Baker, Sheila A., Deane, James A., Cole, Douglas G., Dickert, Bethany L., Rosenbaum, Joel L., Witman, George B., Besharse, Joseph C.

“…Approximately 10% of the photoreceptor outer segment (OS) is turned over each day, requiring large amounts of lipid and protein to be moved from the inner…”
Get full text

Retinal Circadian Clocks and Control of Retinal Physiology by Green, Carla B., Besharse, Joseph C.

“…Retinas of all classes of vertebrates contain endogenous circadian clocks that control many aspects of retinal physiology, including retinal sensitivity to…”
Get full text

Peripheral nerve pathology in sickle cell disease mice by Sadler, Katelyn E., Lewis, Tylor R., Waltz, Tyler B., Besharse, Joseph C., Stucky, Cheryl L.

“…Many patients with sickle cell disease (SCD) suffer from chronic pain, which is often described as neuropathic in nature. Although vascular and inflammatory…”
Get full text

IFT20 Links Kinesin II with a Mammalian Intraflagellar Transport Complex That Is Conserved in Motile Flagella and Sensory Cilia by Baker, Sheila A., Freeman, Katie, Luby-Phelps, Katherine, Pazour, Gregory J., Besharse, Joseph C.

“…Intraflagellar transport (IFT) is an evolutionarily conserved mechanism thought to be required for the assembly and maintenance of all eukaryotic cilia and…”
Get full text

Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development by Insinna, Christine, Baye, Lisa M, Amsterdam, Adam, Besharse, Joseph C, Link, Brian A

“…Photoreceptors of the retina are highly compartmentalized cells that function as the primary sensory neurons for receiving and initiating transmission of…”
Get full text

The kinesin superfamily protein KIF17: one protein with many functions by Wong-Riley Margaret T.T., Besharse Joseph C.

“…Kinesins are ATP-dependent molecular motors that carry cargos along microtubules, generally in an anterograde direction. They are classified into 14 distinct…”
Get full text

Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells by Mikami, Atsushi, Tynan, Sharon H, Hama, Taro, Luby-Phelps, Katherine, Saito, Tetsuichiro, Crandall, James E, Besharse, Joseph C, Vallee, Richard B

“…Cytoplasmic dynein is involved in a wide variety of cellular functions. In addition to the initially characterized form (MAP 1C/dynein 1), a second form of…”
Get full text

174delG mutation in mouse MFRP causes photoreceptor degeneration and RPE atrophy by Fogerty, Joseph, Besharse, Joseph C

“…The authors have identified a recessive mutation causing progressive retinal degeneration, white fundus flecks, and eventual retinal pigment epithelium (RPE)…”
Get full text

Kif17 phosphorylation regulates photoreceptor outer segment turnover by Lewis, Tylor R, Kundinger, Sean R, Link, Brian A, Insinna, Christine, Besharse, Joseph C

“…KIF17, a kinesin-2 motor that functions in intraflagellar transport, can regulate the onset of photoreceptor outer segment development. However, the function…”
Get full text