Search Results - "Beschorner, Niklas"

Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors by Hamann, Martin V, Beschorner, Niklas, Vu, Xuan-Khang, Hauber, Ilona, Lange, Ulrike C, Traenkle, Bjoern, Kaiser, Philipp D, Foth, Daniel, Schneider, Carola, Büning, Hildegard, Rothbauer, Ulrich, Hauber, Joachim

“…Adeno-associated viruses (AAV) are considered non-pathogenic in humans, and thus have been developed into powerful vector platforms for in vivo gene therapy…”
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CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X by Karimova, Madina, Beschorner, Niklas, Dammermann, Werner, Chemnitz, Jan, Indenbirken, Daniela, Bockmann, Jan-Hendrik, Grundhoff, Adam, Lüth, Stefan, Buchholz, Frank, Wiesch, Julian Schulze zur, Hauber, Joachim

“…Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV eradication would require inactivation of the viral genome, which…”
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Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity by Karpinski, Janet, Hauber, Ilona, Chemnitz, Jan, Schäfer, Carola, Paszkowski-Rogacz, Maciej, Chakraborty, Deboyoti, Beschorner, Niklas, Hofmann-Sieber, Helga, Lange, Ulrike C, Grundhoff, Adam, Hackmann, Karl, Schrock, Evelin, Abi-Ghanem, Josephine, Pisabarro, M Teresa, Surendranath, Vineeth, Schambach, Axel, Lindner, Christoph, van Lunzen, Jan, Hauber, Joachim, Buchholz, Frank

“…Excision of integrated HIV proviruses derived from most HIV-1 strains is achieved with a recombinase evolved in vitro . Current combination antiretroviral…”
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Precise excision of HTLV-1 provirus with a designer-recombinase by Rojo-Romanos, Teresa, Karpinski, Janet, Millen, Sebastian, Beschorner, Niklas, Simon, Florian, Paszkowski-Rogacz, Maciej, Lansing, Felix, Schneider, Paul Martin, Sonntag, Jan, Hauber, Joachim, Thoma-Kress, Andrea K., Buchholz, Frank

“…The human T cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that persists as a provirus in the genome of infected cells and can lead to adult…”
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Preclinical toxicity analyses of lentiviral vectors expressing the HIV-1 LTR-specific designer-recombinase Brec1 by Beschorner, Niklas, Künzle, Paul, Voges, Maike, Hauber, Ilona, Indenbirken, Daniela, Nakel, Jacqueline, Virdi, Sanamjeet, Bradtke, Peter, Lory, Niels Christian, Rothe, Michael, Paszkowski-Rogacz, Maciej, Buchholz, Frank, Grundhoff, Adam, Schambach, Axel, Thirion, Christian, Mittrücker, Hans-Willi, Schulze Zur Wiesch, Julian, Hauber, Joachim, Chemnitz, Jan

“…Drug-based antiretroviral therapies (ART) efficiently suppress HIV replication in humans, but the virus persists as integrated proviral reservoirs in small…”
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Improved targeting of human CD4.sup.+ T cells by nanobody-modified AAV2 gene therapy vectors by Hamann, Martin V, Beschorner, Niklas, Vu, Xuan-Khang, Hauber, Ilona, Lange, Ulrike C, Traenkle, Bjoern, Kaiser, Philipp D, Foth, Daniel, Schneider, Carola, Büning, Hildegard, Rothbauer, Ulrich, Hauber, Joachim

“…Adeno-associated viruses (AAV) are considered non-pathogenic in humans, and thus have been developed into powerful vector platforms for in vivo gene therapy…”
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Improving Lentiviral Transduction of CD34 + Hematopoietic Stem and Progenitor Cells by Hauber, Ilona, Beschorner, Niklas, Schrödel, Silke, Chemnitz, Jan, Kröger, Nicolaus, Hauber, Joachim, Thirion, Christian

“…The delivery of therapeutic genes for treatment of inherited or infectious diseases frequently requires lentiviral transduction of CD34 hematopoietic stem and…”
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G-107 Pronounced antiviral activity of next-generation LTR-specific Tre-recombinase by Schäfer, Carola, Karpinski, Janet, Hauber, Ilona, Chemnitz, Jan, Hofmann-Sieber, Helga, Nagel, Claus-Henning, Beschorner, Niklas, Buchholz, Frank, Hauber, Joachim

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d(GGGT)4 and r(GGGU)4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers by Magbanua, Eileen, Zivkovic, Tijana, Hansen, Björn, Beschorner, Niklas, Meyer, Cindy, Lorenzen, Inken, Grötzinger, Joachim, Hauber, Joachim, Torda, Andrew E., Mayer, Günter, Rose-John, Stefan, Hahn, Ulrich

“…Aptamers are oligonucleotides that bind targets with high specificity and affinity. They have become important tools for biosensing, target detection, drug…”
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G-107 Pronounced antiviral activity of next-generation LTR-specific Tre-recombinase by Schäfer, Carola, Karpinski, Janet, Hauber, Ilona, Chemnitz, Jan, Hofmann-Sieber, Helga, Nagel, Claus-Henning, Beschorner, Niklas, Buchholz, Frank, Hauber, Joachim

“…HIV-1 integrates into the host chromosome and persists as a provirus flanked by long terminal repeats (LTRs). To date, treatment regimens primarily target the…”
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Next-generation LTR-specific Tre-recombinase targets a majority of HIV-1 isolates by Hauber, Joachim, Karpinski, Janet, Hauber, Ilona, Chemnitz, Jan, Hofmann-Sieber, Helga, Nagel, Claus-Henning, Beschorner, Niklas, Schäfer, Carola, Buchholz, Frank

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