Search Results - "Besch, Robert"

Melanocyte antigen triggers autoimmunity in human psoriasis by Arakawa, Akiko, Siewert, Katherina, Stöhr, Julia, Besgen, Petra, Kim, Song-Min, Rühl, Geraldine, Nickel, Jens, Vollmer, Sigrid, Thomas, Peter, Krebs, Stefan, Pinkert, Stefan, Spannagl, Michael, Held, Kathrin, Kammerbauer, Claudia, Besch, Robert, Dornmair, Klaus, Prinz, Jörg C

“…Psoriasis vulgaris is a common T cell-mediated inflammatory skin disease with a suspected autoimmune pathogenesis. The human leukocyte antigen (HLA) class I…”
Get full text

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions by Dombrowski, Yvonne, Peric, Mark, Koglin, Sarah, Kammerbauer, Claudia, Göss, Christine, Anz, David, Simanski, Maren, Gläser, Regine, Harder, Jürgen, Hornung, Veit, Gallo, Richard L, Ruzicka, Thomas, Besch, Robert, Schauber, Jürgen

“…The proinflammatory cytokine interleukin-1β (IL-1β) plays a central role in the pathogenesis and the course of inflammatory skin diseases, including psoriasis…”
Get more information

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells by Besch, Robert, Poeck, Hendrik, Hohenauer, Tobias, Senft, Daniela, Häcker, Georg, Berking, Carola, Hornung, Veit, Endres, Stefan, Ruzicka, Thomas, Rothenfusser, Simon, Hartmann, Gunther

“…The retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated antigen 5 (MDA-5) helicases sense viral RNA in infected cells and initiate…”
Get full text

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I by Schmidt, Andreas, Schwerd, Tobias, Hamm, Wolfgang, Hellmuth, Johannes C, Cui, Sheng, Wenzel, Michael, Hoffmann, Franziska S, Michallet, Marie-Cecile, Besch, Robert, Hopfner, Karl-Peter, Endres, Stefan, Rothenfusser, Simon

“…The ATPase retinoid acid-inducible gene (RIG)-I senses viral RNA in the cytoplasm of infected cells and subsequently activates cellular antiviral defense…”
Get full text

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma by Akira, Shizuo, Busch, Dirk, Bscheider, Michael, Meyers, Rachel, Kato, Hiroki, Tüting, Thomas, Gaffal, Evelyn, Anz, David, Renn, Marcel, Rothenfusser, Simon, Kirschnek, Susanne, Schwerd, Tobias, Prinz, Marco, Tormo, Damia, Hellmuth, Johannes, Kalinke, Ulrich, Landsberg, Jennifer, Neuenhahn, Michael, Hartmann, Gunther, Berking, Carola, Maihoefer, Cornelius, Hornung, Veit, Schmidt, Andreas, Morskaya, Svetlana Shulga, Kremmer, Elisabeth, Bourquin, Carole, Poeck, Hendrik, Endres, Stefan, Besch, Robert, Ruland, Jürgen, Häcker, Georg

“…siRNA is used to silence expression of a specific gene and, if modified by a triphosphate at the 5′ end, will also activate the helicase Rig-I, leading to…”
Get full text

IL-17A Enhances Vitamin D3-Induced Expression of Cathelicidin Antimicrobial Peptide in Human Keratinocytes by Peric, Mark, Koglin, Sarah, Kim, Song-Min, Morizane, Shin, Besch, Robert, Prinz, Jorg C, Ruzicka, Thomas, Gallo, Richard L, Schauber, Jurgen

“…Cathelicidin is strongly expressed in lesional skin in psoriasis and may play an important role as both an antimicrobial peptide and as an autoinflammatory…”
Get full text

HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma by Heppt, Markus V, Wessely, Anja, Hornig, Eva, Kammerbauer, Claudia, Graf, Saskia A, Besch, Robert, French, Lars E, Matthies, Alexander, Kuphal, Silke, Kappelmann-Fenzl, Melanie, Bosserhoff, Anja K, Berking, Carola

“…The neural crest transcription factor BRN3A is essential for the proliferation and survival of melanoma cells. It is frequently expressed in melanoma but not…”
Get full text

Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1 by Senft, Daniela, Berking, Carola, Graf, Saskia A, Kammerbauer, Claudia, Ruzicka, Thomas, Besch, Robert

“…Melanoma is an often fatal form of skin cancer which is remarkably resistant against radio- and chemotherapy. Even new strategies that target RAS/RAF signaling…”
Get full text

Targeting the Cytosolic Innate Immune Receptors RIG‐I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma by Glas, Martin, Coch, Christoph, Trageser, Daniel, Daßler, Juliane, Simon, Matthias, Koch, Philipp, Mertens, Jerome, Quandel, Tamara, Gorris, Raphaela, Reinartz, Roman, Wieland, Anja, Von Lehe, Marec, Pusch, Annette, Roy, Kristin, Schlee, Martin, Neumann, Harald, Fimmers, Rolf, Herrlinger, Ulrich, Brüstle, Oliver, Hartmann, Gunther, Besch, Robert, Scheffler, Björn

“…Cellular heterogeneity, for example, the intratumoral coexistence of cancer cells with and without stem cell characteristics, represents a potential root of…”
Get full text

Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1 by Zall, Henry, Weber, Arnim, Besch, Robert, Zantl, Niko, Häcker, Georg

“…Human renal cell carcinoma (RCC) is very resistant to chemotherapy. ABT-737 is a novel inhibitor of anti-apoptotic proteins of the Bcl-2 family that has shown…”
Get full text

Pathogenic DNA: Cytosolic DNA promotes inflammation in psoriasis by Schauber, Jürgen, Dombrowski, Yvonne, Besch, Robert

“…Comment on: Dombrowski Y, et al. Sci Transl Med 2011; 3:82ra38…”
Get full text

Nestin and SOX9 and SOX10 transcription factors are coexpressed in melanoma by Bakos, Renato M., Maier, Tanja, Besch, Robert, Mestel, Dominik S., Ruzicka, Thomas, Sturm, Richard A., Berking, Carola

“…Please cite this paper as: Nestin and SOX9 and SOX10 transcription factors are coexpressed in melanoma. Experimental Dermatology 2010; 19: e89–e94. :  Nestin…”
Get full text

The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival by Hohenauer, Tobias, Berking, Carola, Schmidt, Andreas, Haferkamp, Sebastian, Senft, Daniela, Kammerbauer, Claudia, Fraschka, Sabine, Graf, Saskia Anna, Irmler, Martin, Beckers, Johannes, Flaig, Michael, Aigner, Achim, Höbel, Sabrina, Hoffmann, Franziska, Hermeking, Heiko, Rothenfusser, Simon, Endres, Stefan, Ruzicka, Thomas, Besch, Robert

“…Pigment cells and neuronal cells both are derived from the neural crest. Here, we describe the Pit‐Oct‐Unc (POU) domain transcription factor Brn3a, normally…”
Get full text

Triplex-forming oligonucleotides - sequence-specific DNA ligands as tools for gene inhibition and for modulation of DNA-associated functions by Besch, Robert, Giovannangeli, Carine, Degitz, Klaus

“…The down regulation of gene expression is a promising strategy for molecular medicine and experimental biology. Molecules that bind to the DNA double helix may…”
Get more information

Gene Therapy for Advanced Melanoma: Selective Targeting and Therapeutic Nucleic Acids by Viola, Joana R., Rafael, Diana F., Wagner, Ernst, Besch, Robert, Ogris, Manfred

“…Despite recent advances, the treatment of malignant melanoma still results in the relapse of the disease, and second line treatment mostly fails due to the…”
Get full text

Specific Inhibition of ICAM-1 Expression Mediated by Gene Targeting with Triplex-forming Oligonucleotides by Besch, Robert, Giovannangeli, Carine, Kammerbauer, Claudia, Degitz, Klaus

“…Selected sequences in the DNA double helix can be specifically recognized by oligonucleotides via hydrogen bonding interactions. The resulting triple helix can…”
Get full text

POU transcription factors in melanocytes and melanoma by Besch, Robert, Berking, Carola

“…Re-activation of molecules active in embryogenesis can play an important role in cancer, since they can provide tumor cells with malignant properties. Several…”
Get full text

Bifunctional siRNAs for tumor therapy by Matheis, Fanny, Besch, Robert

“…Double-stranded RNA molecules carrying a triphosphate moiety represent a molecular structure by which the host recognizes viral infections. Such RNA molecules…”
Get more information

SOX10 Promotes Melanoma Cell Invasion by Regulating Melanoma Inhibitory Activity by Graf, Saskia A., Busch, Christian, Bosserhoff, Anja-Katrin, Besch, Robert, Berking, Carola

“…The transcription factor SOX10 (SRY (sex determining region Y)-box 10) has a key role in the embryonic development of melanocytes. Recently, it has been…”
Get full text

In vitro inhibition of Cyprinid herpesvirus-3 replication by RNAi by Gotesman, Michael, Soliman, Hatem, Besch, Robert, El-Matbouli, Mansour

“…•Cyprinid herpesvirus-3 causes high mortality rates in common and koi carp.•siRNAs were designed to target thymidine kinase and DNA polymerase genes in…”
Get full text