Search Results - "Besch, H R"

Ryanodine receptor dysfunction in hearts of streptozotocin-induced diabetic rats by Bidasee, K R, Dinçer, U D, Besch, Jr, H R

“…Studies have shown that evoked calcium release from sarcoplasmic reticulum is compromised in diabetic rat hearts. The present study was undertaken to determine…”
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Dual effect of suramin on calcium fluxes across sarcoplasmic reticulum vesicle membranes by Emmick, J T, Kwon, S, Bidasee, K R, Besch, K T, Besch, Jr, H R

“…Suramin is a polysulfonated naphthylurea developed originally to treat trypanosomiasis. This drug has gained considerable attention recently as an effective…”
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Determination of Complement of mRNA Encoding Inositol 1,4,5-Trisphosphate Receptor Isoforms in Rat Tissues Using Relative-Polymerase Chain Reaction by Gersting, Jason A., Bidasee, Keshore R., Dinçer, Ü.Deniz, Besch, Henry R.

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Ryanodine and inositol trisphosphate receptors are differentially distributed and expressed in rat parotid gland by Zhang, X, Wen, J, Bidasee, K R, Besch, Jr, H R, Wojcikiewicz, R J, Lee, B, Rubin, R P

“…The present study examines the cellular distribution of the ryanodine receptor/channel (RyR) and inositol 1,4,5-trisphosphate receptor (InsP3R) subtypes in…”
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Structural Determinants of High-Affinity Binding of Ryanoids to the Vertebrate Skeletal Muscle Ryanodine Receptor: A Comparative Molecular Field Analysis by Welch, William, Ahmad, Syed, Airey, Judith A, Gerzon, Koert, Humerickhouse, Rod A, Besch, Henry R. Jr, Ruest, Luc, Deslongchamps, Pierre, Sutko, John L

“…Ryanodine binds to specific membrane proteins, altering the calcium permeability of intracellular membranes. In this study 19 ryanoids were isolated or…”
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Thyroid hormone regulation of beta-adrenergic receptor number by L T Williams, R J Lefkowitz, A M Watanabe, D R Hathaway, H R Besch, Jr

“…The effects of exogenous thyroid hormones (thyroxine and triiodothyronine) on beta-adrenergic receptors in the rat myocardium were investigated. The potent…”
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Differential activating and deactivating effects of natural ryanodine congeners on the calcium release channel of sarcoplasmic reticulum: evidence for separation of effects at functionally distinct sites by Humerickhouse, R A, Besch, Jr, H R, Gerzon, K, Ruest, L, Sutko, J L, Emmick, J T

“…Two novel natural ryanoids from extracts of the wood of Ryania speciosa Vahl were evaluated with sarcoplasmic reticulum (SR) vesicles for their binding…”
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Unmasking effect of alamethicin on the (Na+,K+)-ATPase, beta-adrenergic receptor-coupled adenylate cyclase, and cAMP-dependent protein kinase activities of cardiac sarcolemmal vesicles by L R Jones, S W Maddock, H R Besch, Jr

“…A mechanism for the activating effect of alamethicin on membrane enzymes was investigated, using a purified preparation of cardiac sarcolemmal vesicles…”
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Separation of vesicles of cardiac sarcolemma from vesicles of cardiac sarcoplasmic reticulum. Comparative biochemical analysis of component activities by L R Jones, H R Besch, Jr, J W Fleming, M M McConnaughey, A M Watanabe

“…Sarcolemmal and sarcoplasmic reticulum membrane vesicle fractions were isolated from cardiac microsomes. Separation of sarcolemmal and sarcoplasmic reticulum…”
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Effects of ryanodine on calcium sparks in cut twitch fibres of Rana temporaria by Chiu Shuen Hui, Keshore R Bidasee, Henry R Besch, Jr

“…Localized calcium release events (calcium sparks) were studied in voltage-clamped cut twitch fibres of Rana temporaria. A histogram of thousands of spontaneous…”
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Structure-function relationships among ryanodine derivatives. Pyridyl ryanodine definitively separates activation potency from high affinity by Bidasee, K R, Besch, Jr, H R

“…Ryanodine derivatives are differentially effective on the two limbs of the ryanodine concentration-effect curve. This study comparing ryanodine, ryanodol, and…”
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Amiodarone instilled into the canine pericardial sac migrates transmurally to produce electrophysiologic effects and suppress atrial fibrillation by Ayers, G M, Rho, T H, Ben-David, J, Besch, Jr, H R, Zipes, D P

“…We investigated whether amiodarone delivered into the pericardial sac exerted an effect on atrial and ventricular refractoriness, impulse generation, and…”
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Characterization of [3H](±)Carazolol Binding to β-Adrenergic Receptors: Application to Study of β-Adrenergic Receptor Subtypes in Canine Ventricular Myocardium and Lung by MANALAN, ALLAN S, BESCH, HENRY R, WATANABE, AUGUST M

“…[H](±)Carazolol, a newly available β-adrenergic receptor antagonist, has been used to characterize β-adrenergic receptor subtypes present in membrane vesicles…”
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Ryanodine receptor expression is associated with intracellular Ca2+ release in rat parotid acinar cells by Zhang, X, Wen, J, Bidasee, K R, Besch, Jr, H R, Rubin, R P

“…The ryanodine receptor mediates intracellular Ca2+ mobilization in muscle and nerve, but its physiological role in nonexcitable cells is less well defined…”
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Effect of Experience on Medical Students' Attitudes toward Animal Laboratories in Pharmacology Education by Willis, L. R, Besch, Henry R., Jr

“…Students (n=143) at the Indiana University School of Medicine were surveyed--before and after pharmacology laboratory experiences using dogs--for their…”
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Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel by Tinker, A., Sutko, J.L., Ruest, L., Deslongchamps, P., Welch, W., Airey, J.A., Gerzon, K., Bidasee, K.R., Besch, H.R., Williams, A.J.

“…We have examined the effects of a number of derivatives of ryanodine on K+ conduction in the Ca2+ release channel purified from sheep cardiac sarcoplasmic…”
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Tectoridins modulate skeletal and cardiac muscle sarcoplasmic reticulum calcium-release channels by Bidasee, K R, Maxwell, A, Reynolds, W F, Patel, V, Besch, Jr, H R

“…The isoflavones tectoridin (TTR) and 3'-hydroxy TTR (3'-TTR) were isolated from an Ayurvedic herbal preparation Vacä and evaluated for their affinity and…”
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Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines by A M Watanabe, M M McConnaughey, R A Strawbridge, J W Fleming, L R Jones, H R Besch, Jr

“…The effects of the muscarinic cholinergic agonist methacholine on affinity of beta-adrenergic receptors for isoproterenol and on isoproterenol-induced…”
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Structural Components of Ryanodine Responsible for Modulation of Sarcoplasmic Reticulum Calcium Channel Function by Welch, William, Williams, Alan J, Tinker, Andrew, Mitchell, Kathy E, Deslongchamps, Pierre, Lamothe, J, Gerzon, Koert, Bidasee, Keshore R, Besch, Henry R, Airey, Judith A, Sutko, John L, Ruest, Luc

“…Comparative molecular field analysis (CoMFA) was used to analyze the relationship between the structure of a group of ryanoids and the modulation of the…”
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High affinity C10-Oeq ester derivatives of ryanodine. Activator-selective agonists of the sarcoplasmic reticulum calcium release channel by Humerickhouse, R A, Bidasee, K R, Gerzon, K, Emmick, J T, Kwon, S, Sutko, J L, Ruest, L, Besch, H R

“…The plant alkaloids ryanodine and dehydroryanodine are specific and potent modulators of the sarcoplasmic reticulum calcium release channel. In the present…”
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