Search Results - "Bes, Cedric"

Physicochemical and Biological Characterization of RTXM83, a New Rituximab Biosimilar by Cerutti, María L., Pesce, Analía, Bès, Cédric, Seigelchifer, Mauricio

“…Background RTXM83 is a rituximab biosimilar with proven clinical safety and efficacy. It is the first rituximab biosimilar developed and approved in South…”
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Recombinant anti-CD4 antibody 13B8.2 blocks membrane-proximal events by excluding the Zap70 molecule and downstream targets SLP-76, PLC gamma 1, and Vav-1 from the CD4-segregated Brij 98 detergent-resistant raft domains by Chentouf, Myriam, Ghannam, Soufiane, Bès, Cédric, Troadec, Samuel, Cérutti, Martine, Chardès, Thierry

“…The biological effects of rIgG(1) 13B8.2, directed against the CDR3-like loop on the D1 domain of CD4, are partly due to signals that prevent NF-kappaB nuclear…”
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In vitro antitumoral activity of baculovirus-expressed chimeric recombinant anti-CD4 antibody 13B8.2 on T-cell lymphomas by TROADEC, Samuel, CHENTOUF, Myriam, CIRUTTI, Martine, NGUYEN, Brigitte, OLIVE, Daniel, BES, Cedric, CHARDIS, Thierry

“…A baculovirus-expressed chimeric recombinant IgG1 (rIgG1) antibody, with Cgamma1 and Ckappa human constant domains, was derived from the murine monoclonal…”
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Clinical Pharmacokinetic (PK) and Safety (Immunogenicity) of Rituximab Biosimilar RTXM83 in Combination with Chemotherapy CHOP in Patients with Diffuse Large B-Cell Lymphoma (DLBCL) by Florez, Amalia, Di Matteo, Thiago, Fresnillo, Gloria, Tudela, Consuelo, Seigelchifer, Mauricio, Corley, Esteban, Pesce, Analia, Bes, Cedric, Millan, Susana

“…Background: RTXM83 is a rituximab biosimilar candidate manufactured by MAbxience Company. Full spectrum of physicochemical and preclinical studies showed…”
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Development of RTXM83 (a potential rituximab biosimilar): In vitro and in vivo comparability with MabThera by Seigelchifer, Mauricio, Corley, Esteban, Fresnillo, Gloria, Pesce, Analia, Bes, Cedric, Elise, Marie, Florez, Amalia, Millan, Susana, Raha, Tamal

“…Abstract only…”
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Localization of the Discontinuous Immunodominant Region Recognized by Human Anti-thyroperoxidase Autoantibodies in Autoimmune Thyroid Diseases by Bresson, Damien, Cerutti, Martine, Devauchelle, Gérard, Pugnière, Martine, Roquet, Francoise, Bes, Cédric, Bossard, Carine, Chardès, Thierry, Péraldi-Roux, Sylvie

“…The discontinuous immunodominant region (IDR) recognized by autoantibodies directed against the thyroperoxidase (TPO) molecule, a major autoantigen in…”
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Biological activities on T lymphocytes of a baculovirus-expressed chimeric recombinant IgG1 antibody with specificity for the CDR3-like loop on the D1 domain of the CD4 molecule by TROADEC, Samuel, BES, Cédric, CHARDES, Thierry, CHENTOUF, Myriam, NGUYEN, Brigitte, BRIANT, Laurence, JACQUET, Chantal, CHEBLI, Karim, PUGNIERE, Martine, ROQUET, Francoise, CERUTTI, Martine

“…A baculovirus-expressed chimeric recombinant IgG1 (rIgG1) antibody, with Cgamma1 and Ckappa human constant domains, was derived from the murine monoclonal…”
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A peptide mimetic of an anti-CD4 monoclonal antibody by rational design by Casset, Florence, Roux, Florence, Mouchet, Patrick, Bes, Cedric, Chardes, Thierry, Granier, Claude, Mani, Jean-Claude, Pugnière, Martine, Laune, Daniel, Pau, Bernard, Kaczorek, Michel, Lahana, Roger, Rees, Anthony

“…The development of rational methods to design ‘continuous’ sequence mimetics of discontinuous regions of protein sequence has, to now, been only marginally…”
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The chimeric mouse-human anti-CD4 Fab 13B8.2 expressed in baculovirus inhibits both antigen presentation and HIV-1 promoter activation by Bès, C, Cerutti, M, Briant-Longuet, L, Bresson, D, Peraldi-Roux, S, Pugnière, M, Mani, J C, Pau, B, Devaux, C, Granier, C, Devauchelle, G, Chardès, T

“…The anti-CD4 mAb 13B8.2, directed against the CDR3-like loop of the D1 domain of CD4, inhibits signal transduction pathways leading to both T cell activation…”
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Pertinence of kappa and lambda recombinant antibodies directed against thyroid peroxidase in thyroid autoimmune disease by Bresson, D, Chardès, T, Chapal, N, Bès, C, Cerutti, M, Devauchelle, G, Bouanani, M, Mani, J C, Péraldi-Roux, S

“…Forty-one single-chain variable region fragments (scFvs) directed against thyroid peroxidase (TPO) were obtained by phage display libraries constructed from…”
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Recombinant Anti-CD4 Antibody 13B8.2 Blocks Membrane-Proximal Events by Excluding the Zap70 Molecule and Downstream Targets SLP-76, PLC{gamma}1, and Vav-1 from the CD4-Segregated Brij 98 Detergent-Resistant Raft Domains by Chentouf, Myriam, Ghannam, Soufiane, Bes, Cedric, Troadec, Samuel, Cerutti, Martine, Chardes, Thierry

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Application of the Spot method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding: Methods of parallel peptide synthesis and their contributions to deciphering molecular interactions in the immune system by LAUNE, Daniel, MOLINA, Franck, FERRIERES, Gaëlle, VILLARD, Sylvie, BES, Cédric, RIEUNIER, Francois, CHARDES, Thierry, GRANIER, Claude

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Recombinant Anti-CD4 Antibody 13B8.2 Blocks Membrane-Proximal Events by Excluding the Zap70 Molecule and Downstream Targets SLP-76, PLCγ1, and Vav-1 from the CD4-Segregated Brij 98 Detergent-Resistant Raft Domains by Chentouf, Myriam, Ghannam, Soufiane, Bès, Cédric, Troadec, Samuel, Cérutti, Martine, Chardès, Thierry

“…Abstract The biological effects of rIgG1 13B8.2, directed against the CDR3-like loop on the D1 domain of CD4, are partly due to signals that prevent NF-κB…”
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The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases by Chardès, Thierry, Chapal, Nicolas, Bresson, Damien, Bès, Cédric, Giudicelli, Véronique, Lefranc, Marie-Paule, Péraldi-Roux, Sylvie

“…Human anti-thyroid peroxidase (TPO) autoantibodies (aAb) are generated during autoimmune thyroid diseases (AITD). Within recent years, increasing knowledge of…”
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Application of the Spot method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding by Laune, Daniel, Molina, Franck, Ferrières, Gaëlle, Villard, Sylvie, Bès, Cédric, Rieunier, François, Chardès, Thierry, Granier, Claude

“…Overlapping peptide scans prepared by Spot synthesis have been used to map interaction sites in several systems. Here we report our experience with this…”
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Biological actvities on T lymphoycytes of a baculovirus-expressed IgG1 antibody with specificities for the CDR3-like region of the CD4 molecule by Troadec, Samuel, Bès, Cédric, Chentouf, Myriam, Nguyen, Brigitte, Jacquet, Chantal, Chebli, Karim, Pugnière, Martine, Roquet, Françoise, Cerutti, Martine, Chardès, Thierry

“…A baculovirus-expressed chimeric recombinant IgG1 (rIgG1) antibody, with Cgamma1 and Ckappa human constant domains, was derived from the murine monoclonal…”
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PIN-bodies: A new class of antibody-like proteins with CD4 specificity derived from the protein inhibitor of neuronal nitric oxide synthase by Bès, Cédric, Troadec, Samuel, Chentouf, Myriam, Breton, Hélène, Dominique Lajoix, Anne, Heitz, Frédéric, Gross, René, Plückthun, Andreas, Chardès, Thierry

“…By inserting the CB1 paratope-derived peptide (PDP) from the anti-CD4 13B8.2 antibody binding pocket into each of the three exposed loops of the protein…”
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Biological activities on T lymphocytes of a baculovirus-expressed chimeric recombinant IgG 1 antibody with specificity for the CDR3- like loop on the D1 domain of the CD4 molecule by Troadec, Samuel, Bès, Cédric, Chentouf, Myriam, Nguyen, Brigitte, Briant, Laurence, Jacquet, Chantal, Chebli, Karim, Pugnière, Martine, Roquet, Françoise, Cerutti, Martine, Chardès, Thierry

“…A baculovirus-expressed chimeric recombinant IgG 1 (rIgG 1) antibody, with Cγ 1 and Cκ human constant domains, was derived from the murine monoclonal antibody…”
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Localization of the discontinous immunodominant region recognized by human anti-thyroperoxidase autoantibodies in autoimmune thyroid diseases by Bresson, Damien, Cerutti, Martine, Devauchelle, Gerard, Pugnière, Martine, Roquet, Françoise, Bès, Cédric, Bossard, Carine, Chardès, Thierry, Péraldi-Roux, Sylvie

“…The discontinuous immunodominant region (IDR) recognized by autoantibodies directed against the thyroperoxidase (TPO) molecule, a major autoantigen in…”
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Mapping the Paratope of Anti-CD4 Recombinant Fab 13B8.2 by Combining Parallel Peptide Synthesis and Site-directed Mutagenesis by Bès, Cédric, Briant-Longuet, Laurence, Cerutti, Martine, Heitz, Frédéric, Troadec, Samuel, Pugnière, Martine, Roquet, Françoise, Molina, Franck, Casset, Florence, Bresson, Damien, Péraldi-Roux, Sylvie, Devauchelle, Gérard, Devaux, Christian, Granier, Claude, Chardès, Thierry

“…We analyzed antigen-binding residues from the variable domains of anti-CD4 antibody 13B8.2 using the Spot method of parallel peptide synthesis. Sixteen amino…”
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